Search Results - "PATEL, Brijesh V"

Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations by Patel, Brijesh V, Arachchillage, Deepa J, Ridge, Carole A, Bianchi, Paolo, Doyle, James F, Garfield, Benjamin, Ledot, Stephane, Morgan, Cliff, Passariello, Maurizio, Price, Susanna, Singh, Suveer, Thakuria, Louit, Trenfield, Sarah, Trimlett, Richard, Weaver, Christine, Wort, S John, Xu, Tina, Padley, Simon P G, Devaraj, Anand, Desai, Sujal R

“…Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the underlying pathophysiology. To…”
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Resolution of acute lung injury and inflammation: a translational mouse model by PATEL, Brijesh V, WILSON, Michael R, TAKATA, Masao

“…Previous animal models of acute lung injury (ALI) are limited as they only reproduce part of the complex pathobiology of clinical ALI. Here we develop a…”
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TNF-induced death signaling triggers alveolar epithelial dysfunction in acute lung injury by Patel, Brijesh V, Wilson, Michael R, O'Dea, Kieran P, Takata, Masao

“…The ability of the alveolar epithelium to prevent and resolve pulmonary edema is a crucial determinant of morbidity and mortality in acute lung injury (ALI)…”
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In vivo compartmental analysis of leukocytes in mouse lungs by Patel, Brijesh V, Tatham, Kate C, Wilson, Michael R, O'Dea, Kieran P, Takata, Masao

“…The lung has a unique structure consisting of three functionally different compartments (alveolar, interstitial, and vascular) situated in an extreme…”
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The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care by Jenkins, Timothy O., MacBean, Vicky, Poulsen, Mathias Krogh, Karbing, Dan Stieper, Rees, Stephen Edward, Patel, Brijesh V., Polkey, Michael I.

“…Background Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to…”
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Hypoxemia Trajectory of Non-COVID-19 Acute Respiratory Distress Syndrome Patients. An Observational Study Focusing on Hypoxemia Resolver Status by Toal, Connor M., Fowler, Alexander J., Patel, Brijesh V., Puthucheary, Zudin, Prowle, John R.

“…IMPORTANCE: Most studies on acute respiratory distress syndrome (ARDS) group patients by severity based on their initial degree of hypoxemia. However, this…”
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A randomized control trial evaluating the advice of a physiological-model/digital twin-based decision support system on mechanical ventilation in patients with acute respiratory distress syndrome by Patel, Brijesh V., Mumby, Sharon, Johnson, Nicholas, Handslip, Rhodri, Patel, Sunil, Lee, Teresa, Andersen, Martin S., Falaschetti, Emanuela, Adcock, Ian M., McAuley, Danny F., Takata, Masao, Staudinger, Thomas, Karbing, Dan S., Jabaudon, Matthieu, Schellongowski, Peter, Rees, Stephen E.

“…Background Acute respiratory distress syndrome (ARDS) is highly heterogeneous, both in its clinical presentation and in the patient’s physiological responses…”
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Programmed myofibre necrosis in critical illness acquired muscle wasting by Patel, Sunil, Francis, Thomas, Rajaram, Raghini, Handslip, Rhodri, Mumby, Sharon, Bear, Danielle E., Padhke, Rahul, Hart, Nicholas, Montgomery, Hugh, Takata, Masao, Harridge, Stephen D.R., Patel, Brijesh V., Puthucheary, Zudin

“…Background Acute skeletal muscle wasting during critical illness is common and causes significant morbidity and functional limitation. Myofibre necrosis is a…”
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Inhibition of TNF Receptor p55 By a Domain Antibody Attenuates the Initial Phase of Acid-Induced Lung Injury in Mice by Wilson, Michael R, Wakabayashi, Kenji, Bertok, Szabolcs, Oakley, Charlotte M, Patel, Brijesh V, O'Dea, Kieran P, Cordy, Joanna C, Morley, Peter J, Bayliffe, Andrew I, Takata, Masao

“…Tumor necrosis factor-α (TNF) is strongly implicated in the development of acute respiratory distress syndrome (ARDS), but its potential as a therapeutic…”
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Respiratory follow-up of patients with COVID-19 pneumonia by George, Peter M, Barratt, Shaney L, Condliffe, Robin, Desai, Sujal R, Devaraj, Anand, Forrest, Ian, Gibbons, Michael A, Hart, Nicholas, Jenkins, R Gisli, McAuley, Danny F, Patel, Brijesh V, Thwaite, Erica, Spencer, Lisa G

“…The COVID-19 pandemic has led to an unprecedented surge in hospitalised patients with viral pneumonia. The most severely affected patients are older men,…”
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Anticoagulation with argatroban in patients with acute antithrombin deficiency in severe COVID‐19 by Arachchillage, Deepa J., Remmington, Christopher, Rosenberg, Alex, Xu, Tina, Passariello, Maurizio, Hall, Donna, Laffan, Mike, Patel, Brijesh V.

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Right ventricular dysfunction in critically ill COVID-19 ARDS by Bleakley, Caroline, Singh, Suveer, Garfield, Benjamin, Morosin, Marco, Surkova, Elena, Mandalia, Ms Sundhiya, Dias, Bernardo, Androulakis, Emmanouil, Price, Laura C., McCabe, Colm, Wort, Stephen John, West, Cathy, Li, Wei, Khattar, Rajdeep, Senior, Roxy, Patel, Brijesh V., Price, Susanna

“…Comprehensive echocardiography assessment of right ventricular (RV) impairment has not been reported in critically ill patients with COVID-19. We detail the…”
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CLUSTERINg Circulating Histones in Sepsis by Patel, Brijesh V, Lee, Teresa M L, O'Dea, Kieran

“…Patel et al discuss the study by Augusto et al highlighting the functional and translational role for CLU (clusterin), an extracellular chaperone protein and…”
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Potential for personalised application of inhaled nitric oxide in COVID-19 pneumonia by Garfield, Benjamin, McFadyen, Charles, Briar, Charlotte, Bleakley, Caroline, Vlachou, Aikaterini, Baldwin, Melissa, Lees, Nick, Price, Susanna, Ledot, Stephane, McCabe, Colm, Wort, S John, Patel, Brijesh V, Price, Laura C

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Clinical practice, decision-making, and use of clinical decision support systems in invasive mechanical ventilation: a narrative review by Murali, Mayur, Ni, Melody, Karbing, Dan S, Rees, Stephen E, Komorowski, Matthieu, Marshall, Dominic, Ramnarayan, Padmanabhan, Patel, Brijesh V

“…Invasive mechanical ventilation is a key supportive therapy for patients on intensive care. There is increasing emphasis on personalised ventilation…”
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Contrast Echocardiography in VV-ECMO-Dependent Patients with COVID-19 by Bleakley, Caroline, Smith, Rosie, Garfield, Benjamin, Jackson, Timothy, Remmington, Chris, Patel, Brijesh V., Price, Susanna

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Extracorporeal Circulatory Support in Acute Coronary Syndromes: A Systematic Review and Meta-Analysis by Pavasini, Rita, Cirillo, Chiara, Campo, Gianluca, Nobre Menezes, Miguel, Biscaglia, Simone, Tonet, Elisabetta, Ferrari, Roberto, Patel, Brijesh V., Price, Susanna

“…OBJECTIVES:Extracorporeal circulatory support is a life-saving technique, and its use is increasing in acute coronary syndromes. A meta-analysis on pooled…”
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Ventilation with “clinically relevant” high tidal volumes does not promote stretch-induced injury in the lungs of healthy mice by Wilson, Michael R, Patel, Brijesh V, Takata, Masao

“…OBJECTIVE:Ventilator-induced lung injury is a crucial determinant of the outcome of mechanically ventilated patients. Increasing numbers of mouse studies have…”
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Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity by Baldi, Rhianna F, Koh, Marissa W, Thomas, Chubicka, Sabbat, Tomasz, Wang, Bincheng, Tsatsari, Stefania, Young, Kieron, Wilson-Slomkowski, Alexander, Soni, Sanooj, O'Dea, Kieran P, Patel, Brijesh V, Takata, Masao, Wilson, Michael R

“…Mechanical ventilation contributes to the morbidity and mortality of patients in intensive care, likely through the exacerbation and dissemination of…”
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Frequency of Thrombocytopenia and Heparin-Induced Thrombocytopenia in Patients Receiving Extracorporeal Membrane Oxygenation Compared With Cardiopulmonary Bypass and the Limited Sensitivity of Pretest Probability Score by Arachchillage, Deepa R. J., Laffan, Mike, Khanna, Sanjay, Vandenbriele, Christophe, Kamani, Farah, Passariello, Maurizio, Rosenberg, Alex, Aw, TC, Banya, Winston, Ledot, Stephane, Patel, Brijesh V.

“…OBJECTIVES:To ascertain1) the frequency of thrombocytopenia and heparin-induced thrombocytopenia; 2) positive predictive value of the Pretest Probability Score…”
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