Search Results - "PASTERKAMP, G"

The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis by Wesseling, M., Sakkers, T.R., de Jager, S.C.A., Pasterkamp, G., Goumans, M.J.

“…Cell transdifferentiation occurs during cardiovascular development or remodeling either as a pathologic feature in the progression of disease or as a response…”
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Perioperative platelet reactivity over time in patients undergoing vascular surgery: An observational pilot study by Brand Kanters, A R T, Roozendaal, N C, Parr, N M J, Pasterkamp, G, Urbanus, R T, Korporaal, S J A, de Borst, Gert J

“…Despite Antiplatelet therapy (APT), cardiovascular patients undergoing revascularisation remain at high risk for thrombotic events. Individual response to APT…”
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Danger Signals in the Initiation of the Inflammatory Response after Myocardial Infarction by Arslan, F., Pasterkamp, Gerard, Smeets, M. B., de Haan, J. J.

“…During myocardial infarction, sterile inflammation occurs. The danger model is a solid theoretic framework that explains this inflammation as danger associated…”
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A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example by Wesseling, M., Diez-Benavente, E., Mokry, M., den Ruijter, H.M., Pasterkamp, G.

“…The rapid advancements in genome-scale (omics) techniques has created significant opportunities to investigate complex disease mechanisms in tissues and cells…”
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Validation of flow cytometric analysis of platelet function in patients with a suspected platelet function defect by van Asten, I., Schutgens, R. E. G., Baaij, M., Zandstra, J., Roest, M., Pasterkamp, G., Huisman, A., Korporaal, S. J. A., Urbanus, R. T.

“…Essentials The diagnosis of mild platelet function disorders (PFDs) is challenging. Validation of flow cytometric testing in patients with suspected PFDs is…”
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Vascular age to determine cardiovascular disease risk: A systematic review of its concepts, definitions, and clinical applications by Groenewegen, KA, den Ruijter, HM, Pasterkamp, G, Polak, JF, Bots, ML, Peters, Sanne AE

“…BackgroundVascular age is an alternate means of representing an individual's cardiovascular risk. Little consensus exists on what vascular age represents and…”
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Detecting the vulnerable plaque in patients by Gonçalves, I., Ruijter, H., Nahrendorf, M., Pasterkamp, G.

“…Atherosclerosis is a systemic condition that eventually evolves into vulnerable plaques and cardiovascular events. Pathology studies reveal that rupture‐prone…”
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Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus by Reijrink, M, van Ark, J, Lexis, C P H, Visser, L M, Lodewijk, M E, van der Horst, I C C, Zeebregts, C J, van Goor, H, de Jager, S C A, Pasterkamp, G, Wolffenbuttel, B H R, Hillebrands, J L

“…Individuals with type 2 diabetes mellitus (T2DM) have an increased risk for developing macrovascular disease (MVD) manifested by atherosclerosis…”
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Proprotein convertase subtilisin/kexin 6 is involved in lipid metabolism in liver and adipose tissue by Suur, B.E., Chemaly, M., Jin, H., Kronqvist, M., Lengquist, M., Van Der Laan, S.W., Lleal, M. Sabater, Mälarstig, A., Pasterkamp, G., Eriksson, P., Hedin, U., Ketelhuth, D.F.J., Hurt-Camejo, E., Matic, L.

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Vascular age to determine cardiovascular disease risk: A systematic review of its concepts, definitions, and clinical applications by Groenewegen, KA, den Ruijter, HM, Pasterkamp, G, Polak, JF, Bots, ML, Peters, Sanne AE

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Current Status of Clinical Magnetic Resonance Imaging for Plaque Characterisation in Patients with Carotid Artery Stenosis by den Hartog, A.G, Bovens, S.M, Koning, W, Hendrikse, J, Luijten, P.R, Moll, F.L, Pasterkamp, G, de Borst, G.J

“…Abstract Objective The article aims to provide an overview of the literature that assessed the agreement between magnetic resonance imaging (MRI) and histology…”
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Carotid Atherosclerotic Plaques Stabilize After Stroke: Insights Into the Natural Process of Atherosclerotic Plaque Stabilization by Peeters, W, Hellings, W E., de Kleijn, D P.V., de Vries, J P.P.M., Moll, F L., Vink, A, Pasterkamp, G

“…Rupture of unstable atherosclerotic plaques is the pathological substrate for acute ischemic events. Underlying cellular and molecular characteristics of…”
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Circulating MicroRNAs as Novel Biomarkers for the Early Diagnosis of Acute Coronary Syndrome by Deddens, J. C., Colijn, J. M., Oerlemans, M. I. F. J., Pasterkamp, G., Chamuleau, S. A., Doevendans, P. A., Sluijter, J. P. G.

“…Small non-coding microRNAs (miRNAs) are important physiological regulators of post-transcriptional gene expression. miRNAs not only reside in the cytoplasm but…”
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The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease by Demandt, J. A. F., Dubois, L. J., van Kuijk, K., Zaťovičová, M., Jin, H., Parkkila, S., van der Laan, S. W., Jelenska, L., Mees, B. M. E., Reutelingsperger, C. P. M., Cleutjens, K. B. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., van Greevenbroek, M. M. J., Biessen, E. A. L., Pasterkamp, G., Pastoreková, S., Stehouwer, C. D. A., Sluimer, J. C.

“…Hypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic…”
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Radiation-induced Carotid Stenotic Lesions have a more Stable Phenotype than De Novo Atherosclerotic Plaques by Fokkema, M, den Hartog, A.G, van Lammeren, G.W, Bots, M.L, Pasterkamp, G, Vink, A, Moll, F.L, de Borst, G.J

“…Abstract Objective To identify plaque characteristics of carotid artery radiation-induced stenosis. Materials and methods Nineteen carotid plaques were…”
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Polygenic risk scores of lipid-spectra associate with increased risk of cardiovascular events in patients that underwent carotid endarterectomy by Siemelink, M, van der Laan, S.W.L, Pasterkamp, G

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Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults by Keustermans, G. C., Kofink, D., Eikendal, A., de Jager, W., Meerding, J., Nuboer, R., Waltenberger, J., Kraaijeveld, A. O., Jukema, J. W., Sels, J. W., Garssen, J., Prakken, B. J., Asselbergs, F. W., Kalkhoven, E., Hoefer, I. E., Pasterkamp, G., Schipper, H. S.

“…Childhood obesity coincides with increased numbers of circulating classical CD14 ++ CD16 - and intermediate CD14 ++ CD16 + monocytes. Monocytes are key players…”
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Publisher Correction: Optimization of large animal MI models; a systematic analysis of control groups from preclinical studies by Zwetsloot, P. P., Kouwenberg, L. H. J. A., Sena, E. S., Eding, J. E., den Ruijter, H. M., Sluijter, J. P. G., Pasterkamp, G., Doevendans, P. A., Hoefer, I. E., Chamuleau, S. A. J., van Hout, G. P. J., Jansen of Lorkeers, S. J.

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper…”
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Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development by SCHONEVELD, A. H, OUDE NIJHUIS, M. M, VAN MIDDELAAR, B, LAMAN, J. D, DE KLEIJN, D. P. V, PASTERKAMP, G

“…Toll like receptors (Tlr) are essential in activation of the innate immune system. We recently described that peptidoglycan, an exogenous Tlr2 specific ligand,…”
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Effect of vagus nerve stimulation on tissue damage and function loss in a mouse myocardial ischemia-reperfusion model by Nederhoff, M.G.J., Fransen, D.E., Verlinde, S.A.M.W., Brans, M.A.D., Pasterkamp, G., Bleys, R.L.A.W.

“…In cardiac ischemia, acute inflammatory responses further increase the detrimental effect on myocardial tissue. Since vagus nerve stimulation (VS) attenuates…”
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