Search Results - "PASSARELLA, Daniele"

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry by Bonandi, Elisa, Christodoulou, Michael S., Fumagalli, Gaia, Perdicchia, Dario, Rastelli, Giulio, Passarella, Daniele

“…•Triazoles mimic different functional groups, resulting optimal bioisosteres for the synthesis of new active molecules.•Triazoles present a marked stability…”
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Cyrene: A Green Solvent for the Synthesis of Bioactive Molecules and Functional Biomaterials by Citarella, Andrea, Amenta, Arianna, Passarella, Daniele, Micale, Nicola

“…In the panorama of sustainable chemistry, the use of green solvents is increasingly emerging for the optimization of more eco-friendly processes which look to…”
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Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization by Marzullo, Paola, Foschi, Francesca, Coppini, Davide Andrea, Fanchini, Fabiola, Magnani, Lucia, Rusconi, Selina, Luzzani, Marcello, Passarella, Daniele

“…The chemical reactivity of cannabidiol is based on its ability to undergo intramolecular cyclization driven by the addition of a phenolic group to one of its…”
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Convenient Preparation and Spectroscopic Characterization of 7R-Hydroxymatairesinol by Colombo, Eleonora, Paladino, Giuseppe, Ciriello, Umberto, Passarella, Daniele

“…The preparation of 7R-HMR (allo-hydroxymatairesinol) is reported by: (a) NaBH4 kinetic reduction of 7R/7S diastereomeric mixture; and (b) epimerization of the…”
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Total Synthesis of (-)-Anaferine: A Further Ramification in a Diversity-Oriented Approach by Bonandi, Elisa, Tedesco, Giada, Perdicchia, Dario, Passarella, Daniele

“…The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented…”
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Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR by Foschi, Francesca, Tinivella, Annachiara, Crippa, Valentina, Pinzi, Luca, Mologni, Luca, Passarella, Daniele, Rastelli, Giulio

“…EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The…”
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Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives by Citarella, Andrea, Dimasi, Alessandro, Moi, Davide, Passarella, Daniele, Scala, Angela, Piperno, Anna, Micale, Nicola

“…The main protease (M ) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly…”
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Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction by Pinzi, Luca, Conze, Christian, Bisi, Nicolo, Torre, Gabriele Dalla, Soliman, Ahmed, Monteiro-Abreu, Nanci, Trushina, Nataliya I., Krusenbaum, Andrea, Dolouei, Maryam Khodaei, Hellwig, Andrea, Christodoulou, Michael S., Passarella, Daniele, Bakota, Lidia, Rastelli, Giulio, Brandt, Roland

“…Tauopathies such as Alzheimer’s disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. Tau’s…”
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Vincamine by synthesis and semi-synthesis by Bonandi, Elisa, Foschi, Francesca, Marucci, Cristina, Paladino, Giuseppe, Luzzani, Marcello, Passarella, Daniele

“…This review summarizes the main strategies aimed at the total synthesis of vincamine and congeners. Then, our contribution in this field is presented: we…”
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Cannabidiol as Self-Assembly Inducer for Anticancer Drug-Based Nanoparticles by Colombo, Eleonora, Coppini, Davide Andrea, Polito, Laura, Ciriello, Umberto, Paladino, Giuseppe, Hyeraci, Mariafrancesca, Di Paolo, Maria Luisa, Nordio, Giulia, Dalla Via, Lisa, Passarella, Daniele

“…Cannabidiol (CBD) is a biologically active compound present in the plants of the family, used as anticonvulsant, anti-inflammatory, anti-anxiety, and more…”
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Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation by Pedrini, Martina, Iannielli, Angelo, Meneghelli, Lorenzo, Passarella, Daniele, Broccoli, Vania, Seneci, Pierfausto

“…The search for disease-modifying agents targeted against Parkinson's disease led us to rationally design a small array of six Anle138b-centered PROTACs, , , ,…”
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Targeting Ovarian Cancer with Chalcone Derivatives: Cytotoxicity and Apoptosis Induction in HGSOC Cells by Merve Aydin, Elif, Canıtez, İdil Su, Colombo, Eleonora, Princiotto, Salvatore, Passarella, Daniele, Dallavalle, Sabrina, Christodoulou, Michael S, Durmaz Şahin, Irem

“…Ovarian cancer ranks as the eighth most prevalent form of cancer in women across the globe and stands as the third most frequent gynecological cancer,…”
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A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition by Sahin, Irem Durmaz, Christodoulou, Michael S., Guzelcan, Ece Akhan, Koyas, Altay, Karaca, Cigdem, Passarella, Daniele, Cetin-Atalay, Rengul

“…Hepatocellular carcinoma (HCC) ranks as the fifth most common and the second deadliest cancer worldwide. HCC is extremely resistant to the conventional…”
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Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective by Cartelli, Daniele, Casagrande, Francesca, Busceti, Carla Letizia, Bucci, Domenico, Molinaro, Gemma, Traficante, Anna, Passarella, Daniele, Giavini, Erminio, Pezzoli, Gianni, Battaglia, Giuseppe, Cappelletti, Graziella

“…The role of microtubule (MT) dysfunction in Parkinson's disease is emerging. It is still unknown whether it is a cause or a consequence of neurodegeneration…”
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Synthesis and Investigation of the G-Quadruplex Binding Properties of Kynurenic Acid Derivatives with a Dihydroimidazoquinoline-3,5-dione Core by Mazzini, Stefania, Princiotto, Salvatore, Musso, Loana, Passarella, Daniele, Beretta, Giovanni Luca, Perego, Paola, Dallavalle, Sabrina

“…G-quadruplexes are secondary structures originating from nucleic acid regions rich in guanines, which are well known for their involvement in gene…”
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Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies by Riva, Elena, Rencurosi, Anna, Gagliardi, Stefania, Passarella, Daniele, Martinelli, Marisa

“…An efficient total synthesis of the natural alkaloid (+)‐dumetorine by using flow technology is described. The process entailed five separate steps starting…”
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Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 Mpro by Citarella, Andrea, Moi, Davide, Pedrini, Martina, Pérez-Peña, Helena, Pieraccini, Stefano, Stagno, Claudio, Micale, Nicola, Schirmeister, Tanja, Sibille, Giulia, Gribaudo, Giorgio, Silvani, Alessandra, Passarella, Daniele, Giannini, Clelia

“…SARS-CoV-2 Mpro is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus…”
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Self-Assembly Nanoparticles of Natural Bioactive Abietane Diterpenes by Ntungwe, Epole, Domínguez-Martín, Eva María, Bangay, Gabrielle, Garcia, Catarina, Guerreiro, Iris, Colombo, Eleonora, Saraiva, Lucilia, Díaz-Lanza, Ana María, Rosatella, Andreia, Alves, Marta M., Reis, Catarina Pinto, Passarella, Daniele, Rijo, Patricia

“…Different approaches have been reported to enhance penetration of small drugs through physiological barriers; among them is the self-assembly drug conjugates…”
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2-Hydroxyoleic Acid as a Self-Assembly Inducer for Anti-Cancer Drug-Centered Nanoparticles by Antoniou, Antonia I, Nordio, Giulia, Di Paolo, Maria Luisa, Colombo, Eleonora, Gaffuri, Beatrice, Polito, Laura, Amenta, Arianna, Seneci, Pierfausto, Dalla Via, Lisa, Perdicchia, Dario, Passarella, Daniele

“…A potent nontoxic antitumor drug, 2-hydroxyoleic acid ( , 2OHOA) used for membrane lipid therapy, was selected as a self-assembly inducer due to its ability to…”
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Novel chemical probes for the investigation of nonribosomal peptide assembly by Ho, Y T Candace, Leng, Daniel J, Ghiringhelli, Francesca, Wilkening, Ina, Bushell, Dexter P, Kostner, Otto, Riva, Elena, Havemann, Judith, Passarella, Daniele, Tosin, Manuela

“…Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin…”
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