Search Results - "PASHAYAN, N"

Polygenic susceptibility to prostate and breast cancer: implications for personalised screening by Pashayan, N, Duffy, S W, Chowdhury, S, Dent, T, Burton, H, Neal, D E, Easton, D F, Eeles, R, Pharoah, P

“…Background: We modelled the efficiency of a personalised approach to screening for prostate and breast cancer based on age and polygenic risk-profile compared…”
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Implementing risk-stratified screening for common cancers: a review of potential ethical legal and social issues by Hall, A.E., Chowdhury, S., Hallowell, N., Pashayan, N., Dent, T., Pharoah, P., Burton, H.

“…Background The identification of common genetic variants associated with common cancers including breast, prostate and ovarian cancers would allow population…”
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Public health genomics and personalized prevention: lessons from the COGS project by Pashayan, N., Hall, A., Chowdhury, S., Dent, T., Pharoah, P. D. P., Burton, H.

“…Using the principles of public health genomics, we examined the opportunities and challenges of implementing personalized prevention programmes for cancer at…”
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Preconception health care and congenital disorders: mathematical modelling of the impact of a preconception care programme on congenital disorders by Shannon, GD, Alberg, C, Nacul, L, Pashayan, N

“…Objective This study aims to model the impact of preconception care on births with congenital disorders at a national level. Design Mathematical…”
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Mean sojourn time, overdiagnosis, and reduction in advanced stage prostate cancer due to screening with PSA: implications of sojourn time on screening by Pashayan, N, Duffy, S W, Pharoah, P, Greenberg, D, Donovan, J, Martin, R M, Hamdy, F, Neal, D E

“…This study aimed to assess the mean sojourn time (MST) of prostate cancer, to estimate the probability of overdiagnosis, and to predict the potential reduction…”
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41 Clinical Applications of Genome-wide Association Study Data - Lessons from Breast and Prostate Cancer by Ponder, B, Pharoah, P, Pashayan, N

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Burden of disease due to cancer in England and Wales by Jayatilleke, N., Pashayan, N., Powles, J.W.

“…Background This study aims to estimate the burden of cancer in England and Wales using disability-adjusted life years (DALYs) and to determine if the ranking…”
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Stratified cancer screening: the practicalities of implementation by Dent, T, Jbilou, J, Rafi, I, Segnan, N, Törnberg, S, Chowdhury, S, Hall, A, Lyratzopoulos, G, Eeles, R, Eccles, D, Hallowell, N, Pashayan, N, Pharoah, P, Burton, H

“…Improving understanding of the genetic basis of disease susceptibility enables us to estimate individuals' risk of developing cancer and offer them disease…”
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Excess cases of prostate cancer and estimated overdiagnosis associated with PSA testing in East Anglia by PASHAYAN, N, POWLES, J, BROWN, C, DUFFY, S. W

“…This study aimed to estimate the extent of 'overdiagnosis' of prostate cancer attributable to prostate-specific antigen (PSA) testing in the Cambridge area…”
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Corrigendum to “Domestic violence, the Lebanese experience” [Public Health 121 (2007): 208–219] by Usta, J, Farver, J.A.M, Pashayan, N

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Incidence trends of prostate cancer in East Anglia, before and during the era of PSA diagnostic testing by PASHAYAN, N, POWLES, J, BROWN, C, DUFFY, S. W

“…We investigated prostate cancer incidence in East Anglia from 1971 to 2000. Using age-period-cohort modelling, the number of cases expected in 1991-2000, based…”
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Excess cases of prostate cancer and estimated overdiagnosis associated with PSA testing in East Anglia by Pashayan, N, Powles, J, Brown, C, Duffy, S W

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Survival trends for small intestinal cancer in England and Wales, 1971-1990: national population-based study by PASHAYAN, N, LEPAGE, C, RACHET, B, WOODS, L. M, COLEMAN, M. P

“…This population-based study examines prognostic factors and survival trends among adults (15-99 years) diagnosed with small intestinal cancer in England and…”
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Personalized early detection and prevention of breast cancer: ENVISION consensus statement by Pashayan, Nora, Antoniou, Antonis C., Ivanus, Urska, Esserman, Laura J., Easton, Douglas F., French, David, Sroczynski, Gaby, Hall, Per, Cuzick, Jack, Evans, D. Gareth, Simard, Jacques, Garcia-Closas, Montserrat, Schmutzler, Rita, Wegwarth, Odette, Pharoah, Paul, Moorthie, Sowmiya, De Montgolfier, Sandrine, Baron, Camille, Herceg, Zdenko, Turnbull, Clare, Balleyguier, Corinne, Rossi, Paolo Giorgi, Wesseling, Jelle, Ritchie, David, Tischkowitz, Marc, Broeders, Mireille, Reisel, Dan, Metspalu, Andres, Callender, Thomas, de Koning, Harry, Devilee, Peter, Delaloge, Suzette, Schmidt, Marjanka K., Widschwendter, Martin

“…The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia…”
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Epigenome-based cancer risk prediction: rationale, opportunities and challenges by Widschwendter, Martin, Jones, Allison, Evans, Iona, Reisel, Daniel, Dillner, Joakim, Sundström, Karin, Steyerberg, Ewout W., Vergouwe, Yvonne, Wegwarth, Odette, Rebitschek, Felix G., Siebert, Uwe, Sroczynski, Gaby, de Beaufort, Inez D., Bolt, Ineke, Cibula, David, Zikan, Michal, Bjørge, Line, Colombo, Nicoletta, Harbeck, Nadia, Dudbridge, Frank, Tasse, Anne-Marie, Knoppers, Bartha M., Joly, Yann, Teschendorff, Andrew E., Pashayan, Nora

“…Key Points Epigenetic misprogramming is an essential component of cancer development. DNA methylation-based risk-prediction models provide novel opportunities…”
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Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor by Litchfield, Kevin, Levy, Max, Orlando, Giulia, Loveday, Chey, Law, Philip J, Migliorini, Gabriele, Holroyd, Amy, Broderick, Peter, Karlsson, Robert, Haugen, Trine B, Kristiansen, Wenche, Nsengimana, Jérémie, Fenwick, Kerry, Assiotis, Ioannis, Kote-Jarai, ZSofia, Dunning, Alison M, Muir, Kenneth, Peto, Julian, Eeles, Rosalind, Easton, Douglas F, Dudakia, Darshna, Orr, Nick, Pashayan, Nora, Bishop, D Timothy, Reid, Alison, Huddart, Robert A, Shipley, Janet, Grotmol, Tom, Wiklund, Fredrik, Houlston, Richard S, Turnbull, Clare

“…Clare Turnbull and colleagues report discovery of 19 new susceptibility loci for testicular germ cell tumor (TGCT) and provide evidence for a network of…”
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The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples by Barrett, James E., Herzog, Chiara, Jones, Allison, Leavy, Olivia C., Evans, Iona, Knapp, Susanne, Reisel, Daniel, Nazarenko, Tatiana, Kim, Yoo-Na, Franchi, Dorella, Ryan, Andy, Franks, Joanna, Bjørge, Line, Zikan, Michal, Cibula, David, Harbeck, Nadia, Colombo, Nicoletta, Dudbridge, Frank, Jones, Louise, Sundström, Karin, Dillner, Joakim, Rådestad, Angelique Flöter, Gemzell-Danielsson, Kristina, Pashayan, Nora, Widschwendter, Martin

“…Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples…”
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Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial by Martin, Richard M, Turner, Emma L, Young, Grace J, Metcalfe, Chris, Walsh, Eleanor I, Lane, J Athene, Sterne, Jonathan A C, Noble, Sian, Holding, Peter, Ben-Shlomo, Yoav, Williams, Naomi J, Pashayan, Nora, Bui, Mai Ngoc, Albertsen, Peter C, Seibert, Tyler M, Zietman, Anthony L, Oxley, Jon, Adolfsson, Jan, Mason, Malcolm D, Davey Smith, George, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L

“…The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer…”
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PSA density and clinical outcome in MRI-based active surveillance for prostate cancer: A joint longitudinal-survival analysis by Stavrinides, V., Papageorgiou, G., Danks, D., Giganti, F., Pashayan, N., Trock, B., Freeman, A., Whitaker, H., Allen, C., Kirkham, A., Sonn, G., Punwani, S., Barratt, D., Emberton, M., Moore, C.

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Incorporating genomics into breast and prostate cancer screening: assessing the implications by Chowdhury, Susmita, Dent, Tom, Pashayan, Nora, Hall, Alison, Lyratzopoulos, Georgios, Hallowell, Nina, Hall, Per, Pharoah, Paul, Burton, Hilary

“…Individual risk prediction and stratification based on polygenic profiling may be useful in disease prevention. Risk-stratified population screening based on…”
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