Search Results - "PARKKILA, S."

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease by Demandt, J. A. F., Dubois, L. J., van Kuijk, K., Zaťovičová, M., Jin, H., Parkkila, S., van der Laan, S. W., Jelenska, L., Mees, B. M. E., Reutelingsperger, C. P. M., Cleutjens, K. B. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., van Greevenbroek, M. M. J., Biessen, E. A. L., Pasterkamp, G., Pastoreková, S., Stehouwer, C. D. A., Sluimer, J. C.

“…Hypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic…”
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Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV by Hilvo, M, Innocenti, A, Monti, S M, De Simone, G, Supuran, C T, Parkkila, S

“…The carbonic anhydrase (CA) enzyme family consists of thirteen active isozymes in mammals. The most recently characterized members of this family are cytosolic…”
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Effect of genetic polymorphisms in CA6 gene on the expression and catalytic activity of human salivary carbonic anhydrase VI by Aidar, M, Marques, Rocha, Valjakka, J, Mononen, N, Lehtimäki, T, Parkkila, S, de Souza, A P, Line, S R Peres

“…Carbonic anhydrase isoenzyme VI (CA VI) plays an important role in the homeostasis of oral tissues participating in the processes of taste, protection of…”
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Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2 by Ohradanova, A, Gradin, K, Barathova, M, Zatovicova, M, Holotnakova, T, Kopacek, J, Parkkila, S, Poellinger, L, Pastorekova, S, Pastorek, J

“…Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally…”
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Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype by Barathova, M, Takacova, M, Holotnakova, T, Gibadulinova, A, Ohradanova, A, Zatovicova, M, Hulikova, A, Kopacek, J, Parkkila, S, Supuran, C T, Pastorekova, S, Pastorek, J

“…CA IX is a hypoxia-induced, cancer-associated carbonic anhydrase isoform with functional involvement in pH control and cell adhesion. Here we describe an…”
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Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours by Hynninen, P, Vaskivuo, L, Saarnio, J, Haapasalo, H, Kivelä, J, Pastoreková, S, Pastorek, J, Waheed, A, Sly, W S, Puistola, U, Parkkila, S

“…Aims Carbonic anhydrase (CA) isozymes IX and XII have been suggested to play a role in oncogenic processes. The aim of the present study was to investigate CA…”
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Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts by Pastorekova, S, Parkkila, S, Parkkila, AK, Opavsky, R, Zelnik, V, Saarnio, J, Pastorek, J

“…BACKGROUND & AIMS: CA IX (formerly MN protein) is a carbonic anhydrase isoenzyme whose expression is associated with human tumors. However, it has also been…”
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Expression of the Membrane-associated Carbonic Anhydrase Isozyme XII in the Human Kidney and Renal Tumors by Parkkila, Seppo, Parkkila, Anna-Kaisa, Saarnio, Juha, Kivela, Jyrki, Karttunen, Tuomo J, Kaunisto, Kari, Waheed, Abdul, Sly, William S, Tureci, Ozlem, Virtanen, Ismo, Rajaniemi, Hannu

“…Carbonic anhydrase isozyme XII (CA XII) is a novel membrane-associated protein with a potential role in von Hippel–Lindau carcinogenesis. Although Northern…”
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Distribution of the carbonic anhydrase isoenzymes I, II, and VI in the human alimentary tract by Parkkila, S, Parkkila, A K, Juvonen, T, Rajaniemi, H

“…The distribution of carbonic anhydrase isoenzymes I, II, and VI was studied in the human alimentary tract using specific antibodies to human isoenzymes in…”
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Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study by Satta, J., Laurila, A., Pääkkö, P., Haukipuro, K., Sormunen, R., Parkkila, S., Juvonen, T.

“…To investigate (i) elastin degradation and the possible association between proteolysis and inflammation in abdominal aortic aneurysm disease (AAA), and (ii)…”
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Acetaldehyde adducts in blood and bone marrow of patients with ethanol-induced erythrocyte abnormalities by Latvala, J, Parkkila, S, Melkko, J, Niemelä, O

“…Although alcohol abuse is known to cause a wide array of adverse effects on blood cell formation, the molecular mechanisms by which alcohol exerts its toxic…”
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Mitochondrial Carbonic anhydrase in the nervous system : Expression in neuronal and glial cells by SAID GHANDOUR, M, PARKKILA, Anna-Kaisa, PARKKILA, Seppo, WAHEED, Abdul, SLY, William S

“…Carbonic anhydrase (CA) V is a mitochondrial enzyme that has been reported in several tissues of the gastrointestinal tract. In liver, it participates in…”
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Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium by Karhumaa, P., Parkkila, S., Türeci, Ö., Waheed, A., Grubb, J.H., Shah, G., Parkkila, A.-K., Kaunisto, K., Tapanainen, J., Sly, W.S., Rajaniemi, H.

“…Although previous studies demonstrated carbonic anhydrase (CA) activity in the human endometrium, the CA isozyme(s) responsible for this activity has not been…”
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Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region by Worrall, S., Niemela, O., Parkkila, S., Peters, T. J., Preedy, V. R.

“…Background Chronic alcoholic myopathy is characterised by reduced muscle strength and structural changes including a decrease in the diameter of Type II…”
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Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation by Niemelä, O, Parkkila, S, Ylä-Herttuala, S, Halsted, C, Witztum, J L, Lanca, A, Israel, Y

“…The primary mechanisms of ethanol-induced tissue damage have been suggested to include aldehyde-derived protein modifications resulting from ethanol metabolism…”
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Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization by Fleming, R E, Parkkila, S, Parkkila, A K, Rajaniemi, H, Waheed, A, Sly, W S

“…Carbonic anhydrase IV (CA IV) is a glycosylphosphatidylinositol-linked isozyme previously identified on the surface of renal tubular epithelium and certain…”
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Recent Advances In the Pathology of Alcoholic Myopathy by Preedy, Victor R., Adachi, Junko, Peters, Timothy J., Worrall, Simon, Parkkila, Seppo, Niemela, Onni, Asamo, Migiwa, Ueno, Yasuhino, Takeda, Kunihiko, Yamauchi, Masayoshi, Sakamoto, Kazuhiko, Takagi, Masaru, Nakajima, Hisato, Toda, Gotaro

“…This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Victor R. Preedy and Junko Adachi. The…”
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P02.09.B HYPOXIA MODULATES DIFFUSE ASTROCYTOMA TUMOR MICROENVIRONMENT THROUGH CELL-TYPE-DEPENDENT RESPONSES by Tiihonen, A, Salonen, I, Koivisto, I, Ritamäki, A, Jaatinen, S, Hyvärinen, T, Kreutzer, J, Mohammadlou, M, Valkonen, M, Ruusuvuori, P, Parkkila, S, Kallio, P, Hagman, S, Kesseli, J, Ravi, V M, Haapasalo, H, Jukkola, A, Joseph, K, Rautajoki, K J

“…Abstract BACKGROUND Diffuse astrocytomas, especially glioblastomas (GBs), are aggressive brain tumors with a poor prognosis despite the efforts to improve…”
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Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands by Parkkila, S, Kaunisto, K, Rajaniemi, L, Kumpulainen, T, Jokinen, K, Rajaniemi, H

“…Human salivary carbonic anhydrase (HCA VI) was purified by inhibitor affinity chromatography and its location in the human parotid and submandibular glands…”
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Expression of carbonic anhydrase isoenzymes IV and II in rat epididymal duct by KAUNISTO, K, PARKKILA, S, PARKKILA, A.-K, ABDUL WAHEED, SLY, W. S, RAJANIEMI, H

“…Acidic epididymal fluid mainly accounts for sperm quiescence during storage in the epididymis. Carbonic anhydrase (CA) is an enzyme involved in proton and…”
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