Search Results - "PARKHOUSE, R. M. E."

A novel TLR3 inhibitor encoded by African swine fever virus (ASFV) by de Oliveira, V. L., Almeida, S. C. P., Soares, H. R., Crespo, A., Marshall-Clarke, S., Parkhouse, R. M. E.

“…African swine fever virus (ASFV) encodes proteins that manipulate important host antiviral mechanisms. Bioinformatic analysis of the ASFV genome revealed ORF…”
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Virus manipulation of cell cycle by Nascimento, R, Costa, H, Parkhouse, R. M. E

“…Viruses depend on host cell resources for replication and access to those resources may be limited to a particular phase of the cell cycle. Thus manipulation…”
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conserved UL24 family of human alpha, beta and gamma herpesviruses induces cell cycle arrest and inactivation of the cyclinB/cdc2 complex by Nascimento, R, Dias, J. D, Parkhouse, R. M. E

“…The conserved murine gammaherpesvirus 68 ORF20 has recently been demonstrated to induce G2 cell cycle arrest followed by apoptosis in human and mouse cells…”
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non-haemadsorbing African swine fever virus isolate ASFV/NH/P68 provides a model for defining the protective anti-virus immune response by Leitao, A, Cartaxeiro, C, Coelho, R, Cruz, B, Parkhouse, R.M.E, Portugal, F.C, Vigario, J.D, Martins, C.L.V

“…African swine fever virus ASFV/NH/P68 is a naturally occurring, non-haemadsorbing and non-fatal isolate. Longitudinal clinical and immunological studies on 31…”
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Expression, cellular localization and antibody responses of the African swine fever virus genes B602L and K205R by Gutiérrez-Castañeda, B., Reis, A. L., Corteyn, A., Parkhouse, R. M. E., Kollnberger, S.

“…Previously, we identified serological immunodeterminants of African swine fever virus (ASFV), including pK205R and pB602L, without homologues in the database…”
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MHV-68 Open Reading Frame 20 is a nonessential gene delaying lung viral clearance by Nascimento, R, Costa, H, Dias, J. D, Parkhouse, R. M. E

“…Recently, it has been demonstrated that the MHV-68 ORF20-encoded gene product induces cell-cycle arrest at the G2/M phase, followed by apoptosis. To study the…”
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CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress by Sarmento, L M, Póvoa, V, Nascimento, R, Real, G, Antunes, I, Martins, L R, Moita, C, Alves, P M, Abecasis, M, Moita, L F, Parkhouse, R M E, Meijerink, J P P, Barata, J T

“…Checkpoint kinase 1 (CHK1) is a key component of the ATR (ataxia telangiectasia-mutated and Rad3-related)-dependent DNA damage response pathway that protect…”
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In vivo depletion of CD8+ T lymphocytes abrogates protective immunity to African swine fever virus by Oura, C. A. L, Denyer, M. S, Takamatsu, H, Parkhouse, R. M. E

“…Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK Correspondence C. A. L. Oura chris.oura{at}bbsrc.ac.uk To understand the…”
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Recombinant Antigen Targets for Serodiagnosis of African Swine Fever by Gallardo, Carmina, Reis, Ana Luísa, Kalema-Zikusoka, Gladys, Malta, Joana, Soler, Alejandro, Blanco, Esther, Parkhouse, R M E, Leitão, Alexandre

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Systematic analysis of longitudinal serological responses of pigs infected experimentally with African swine fever virus by Reis, A.L, Parkhouse, R.M.E, Penedos, A.R, Martins, C, Leitao, A

“…The protective immune response to African swine fever virus (ASFV) includes both cellular and serological components. In this study, the role of antibodies in…”
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Detection of HP10 antigen in serum for diagnosis and follow-up of subarachnoidal and intraventricular human neurocysticercosis by Fleury, A, Hernández, M, Avila, M, Cárdenas, G, Bobes, R J, Huerta, M, Fragoso, G, Uribe-Campero, L, Harrison, L J S, Parkhouse, R M E, Sciutto, E

“…Introduction: Neurocysticercosis (NC), a parasitic disease caused by Taenia solium, may be either asymptomatic or show a mild to severe clinical picture with…”
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Murine gammaherpesvirus 68 ORF20 induces cell-cycle arrest in G2 by inhibiting the Cdc2-cyclin B complex by Nascimento, R, Parkhouse, R. M. E

“…Instituto Gulbenkian de Ciência, Apartado 14, Oeiras, Portugal Correspondence R. M. E. Parkhouse parkhous{at}igc.gulbenkian.pt The objective of this work was…”
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Treatment of monocytes with interleukin (IL)‐12 plus IL‐18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10 by Coma, G., Peña, R., Blanco, J., Rosell, A., Borras, F. E., Esté, J. A., Clotet, B., Ruiz, L., Parkhouse, R. M. E., Bofill, M.

“…Summary During inflammation, interleukin (IL)‐12 and IL‐18 are produced by macrophages and other cell types such as neutrophils (IL‐12), keratinocytes and…”
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Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38 by Howard, Maureen, Grimaldi, J. Christopher, Bazan, J. Fernando, Lund, Frances E., Santos-Argumedo, Leopoldo, Parkhouse, R. M. E., Walseth, Timothy F., Lee, Hon Cheung

“…CD38 is a 42-kilodalton glycoproteln expressed extensively on B and T lymphocytes. CD38 exhibits a structural homology to Aplysia adenosine diphosphate…”
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Identification of the principal serological immunodeterminants of African swine fever virus by screening a virus cDNA library with antibody by Kollnberger, S.D, Gutierrez-Castaneda, B, Foster-Cuevas, M, Corteyn, A, Parkhouse, R.M.E

“…Protective immunity to African swine fever virus (ASFV) may involve a combination of both serological and cellular mechanisms. This work is focused on the…”
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Parasitic diseases of the central nervous system: lessons for clinicians and policy makers by Carpio, Arturo, Romo, Matthew L, Parkhouse, R M E, Short, Brooke, Dua, Tarun

“…Parasitic diseases of the central nervous system are associated with high mortality and morbidity, especially in resource-limited settings. The burden of these…”
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CD2v protein of African swine fever virus interacts with the actin-binding adaptor protein SH3P7 by Kay-Jackson, P.C, Goatley, L.C, Cox, L, Miskin, J.E, Parkhouse, R.M.E, Wienands, J, Dixon, L.K

“…1 Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK 2 Gulbenkian Institute of Science, Oeiras, Portugal 3…”
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Transmission of porcine cysticercosis in the Portuguesa state of Venezuela by Rojas, R. Glenda, Patiño, Fabián, Pérez, Jesús, Medina, Claudio, Lares, María, Méndez, César, Aular, Johan, Parkhouse, R. M. E., Cortéz, María M.

“…The aim of this study was to assess transmission of Taenia solium cysticercosis in Palmarito Arriba, a small village in the rural area of the Portuguesa state…”
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Selective B-cell expression of the MHV-68 latency-associated M2 protein regulates T-dependent antibody response and inhibits apoptosis upon viral infection by de Oliveira, V L, Almeida, S C P, Soares, H R, Parkhouse, R M E

“…To better understand the role of the M2 protein of the murine herpes virus strain 68 (MHV-68) in vivo, B-lymphocyte-restricted, M2-transgenic mice were…”
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A possible overwintering mechanism for bluetongue virus in the absence of the insect vector by Takamatsu, H, Mellor, P. S, Mertens, P. P. C, Kirkham, P. A, Burroughs, J. N, Parkhouse, R. M. E

“…Institute for Animal Health, Pirbright Laboratory, Woking, Surrey GU24 0NF, UK Correspondence Peter Mertens peter.mertens{at}bbsrc.ac.uk Bluetongue virus (BTV)…”
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