Search Results - "PARKER, Thomas G"

Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer by Wang, Chunyang, Tao, Weiyang, Wang, Youdong, Bikow, Jennifer, Lu, Bingxin, Keating, Armand, Verma, Subodh, Parker, Thomas G, Han, Ruifa, Wen, Xiao-Yan

“…Abstract Background Prostate cancer (PCa) is the most common malignancy in males in Western countries. Despite improvements in standard treatments such as…”
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Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology by Tsoporis, James N., Drosatos, Ioannis-Alexandros, Gupta, Sahil, Amatullah, Hajera, Izhar, Shehla, dos Santos, Claudia C., Salpeas, Vasileos, Rigopoulos, Angelos G., Toumpoulis, Ioannis K., Triantafyllis, Andreas S., Sakadakis, Eleftharios, Kavantzas, Nikolaos, Marshall, John C., Rizos, Ioannis K., Parker, Thomas G.

“…DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of…”
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Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes by Tsoporis, James N, Hatziagelaki, Erifili, Gupta, Sahil, Izhar, Shehla, Salpeas, Vasileos, Tsiavou, Anastasia, Rigopoulos, Angelos G, Triantafyllis, Andreas S, Marshall, John C, Parker, Thomas G, Rizos, Ioannis K

“…We determined whether plasma concentrations of the receptor for advanced glycation end products (RAGE) and the soluble (s) form of RAGE (sRAGE) in healthy…”
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BRCA1 is an essential regulator of heart function and survival following myocardial infarction by Shukla, Praphulla C., Singh, Krishna K., Quan, Adrian, Al-Omran, Mohammed, Teoh, Hwee, Lovren, Fina, Cao, Liu, Rovira, Ilsa I., Pan, Yi, Brezden-Masley, Christine, Yanagawa, Bobby, Gupta, Aanika, Deng, Chu-Xia, Coles, John G., Leong-Poi, Howard, Stanford, William L., Parker, Thomas G., Schneider, Michael D., Finkel, Toren, Verma, Subodh

“…The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer but its role in protecting other tissues from DNA damage has not been explored…”
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S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll‐like receptor 4 by Rohde, David, Schön, Christoph, Boerries, Melanie, Didrihsone, Ieva, Ritterhoff, Julia, Kubatzky, Katharina F, Völkers, Mirko, Herzog, Nicole, Mähler, Mona, Tsoporis, James N, Parker, Thomas G, Linke, Björn, Giannitsis, Evangelos, Gao, Erhe, Peppel, Karsten, Katus, Hugo A, Most, Patrick

“…Members of the S100 protein family have been reported to function as endogenous danger signals (alarmins) playing an active role in tissue inflammation and…”
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Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia‐Reperfusion by Mofid, Azadeh, Newman, Nadav S., Lee, Paul J. H., Abbasi, Cynthia, Matkar, Pratiek N., Rudenko, Dmitriy, Kuliszewski, Michael A., Chen, Hao H., Afrasiabi, Kolsoom, Tsoporis, James N., Gramolini, Anthony O., Connelly, Kim A., Parker, Thomas G., Leong‐Poi, Howard

“…Background Cardiomyocyte‐specific transgenic mice overexpressing S100A6, a member of the family of EF‐hand calcium‐binding proteins, develop less cardiac…”
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Differential Expression of Circulating Damage-Associated Molecular Patterns in Patients with Coronary Artery Ectasia by Tsoporis, James N, Triantafyllis, Andreas S, Kalogeropoulos, Andreas S, Izhar, Shehla, Rigopoulos, Angelos G, Rallidis, Loukianos S, Sakadakis, Eleftherios, Toumpoulis, Ioannis K, Salpeas, Vasileios, Leong-Poi, Howard, Parker, Thomas G, Rizos, Ioannis

“…Coronary artery ectasia (CAE) is defined as abnormal dilation of a coronary artery with a diameter exceeding that of adjacent normal arterial segment by >1.5…”
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Differential Regulation of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGEs) and Its Ligands S100A8/A9 Four Weeks Post an Exercise Intervention in a Cohort of Young Army Recruits by Drosatos, Ioannis-Alexandros, Tsoporis, James N, Izhar, Shehla, Gupta, Sahil, Tsirebolos, George, Sakadakis, Eleftherios, Triantafyllis, Andreas S, Rigopoulos, Angelos, Rigopoulos, Dimitrios, Rallidis, Loukianos S, Rizos, Ioannis, Parker, Thomas G

“…Apart from its beneficial effects on cardiovascular risk factors, an anti-inflammatory effect of exercise is strongly implicated. Yet, data regarding the…”
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DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression by Tsoporis, James N, Amatullah, Hajera, Gupta, Sahil, Izhar, Shehla, Ektesabi, Amin M, Vaswani, Chirag M, Desjardins, Jean-Francois, Kabir, Golam, Teixera Monteiro, Ana Paula, Varkouhi, Amir K, Kavantzas, Nikolaos, Salpeas, Vasileios, Rizos, Ioannis, Marshall, John C, Parker, Thomas G, Leong-Poi, Howard, Dos Santos, Claudia C

“…Oxidative stress is considered one of the early underlying contributors of sepsis-induced myocardial depression. DJ-1, also known as PARK7, has a…”
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Emergent Inflammatory Markers and Echocardiographic Indices in Patients with Bronchial Asthma by Gkavogiannakis, Nikolaos A, Tsoporis, James N, Drosatos, Ioannis-Alexandros, Tsirebolos, George, Izhar, Shehla, Sakadakis, Eleftherios, Triantafyllis, Andreas S, Parker, Thomas G, Kalogiros, Lampros A, Leong-Poi, Howard, Rallidis, Loukianos S, Rizos, Ioannis

“…Asthma is a heterogeneous disease, characterized by chronic inflammation and oxidative stress of the airways. Several inflammatory pathways including…”
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Conditional cardiac overexpression of S100A6 attenuates myocyte hypertrophy and apoptosis following myocardial infarction by Tsoporis, James T, Izhar, Shehla, Desjardins, Jean-Francois, Leong-Poi, Howard, Parker, Thomas G

“…S100A6, a 20 kDa, Ca2+ - binding dimer with low basal cardiac expression, is upregulated in the rat heart following infarction and forced expression of S100A6…”
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Salutary effect of resveratrol on sepsis-induced myocardial depression by Smeding, Lonneke, Leong-Poi, Howard, Hu, Pingzhao, Shan, Yuexin, Haitsma, Jack J, Horvath, Eva, Furmli, Suleiman, Masoom, Hussain, Kuiper, Jan Willem, Slutsky, Arthur S, Parker, Thomas G, Plötz, Frans B, dos Santos, Claudia C

“…OBJECTIVES:We hypothesized that resveratrol administration would reverse sepsis-dependent downregulation of peroxisome proliferator activated receptor-γ…”
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Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): The first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction by Taljaard, Monica, PhD, Ward, Michael R., PhD, Kutryk, Michael J.B., MD PhD, Courtman, David W., PhD, Camack, Nancy J., RN, MBA, Goodman, Shaun G., MD, MSc, Parker, Thomas G., MD, Dick, Alexander J., MD, Galipeau, Jacques, MD, Stewart, Duncan J., MD

“…Background Despite the widespread use of pharmacological and/or interventional reperfusion therapies, recovery of cardiac function in myocardial infarction…”
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BRCA2 Protein Deficiency Exaggerates Doxorubicin-induced Cardiomyocyte Apoptosis and Cardiac Failure by Singh, Krishna K., Shukla, Praphulla C., Quan, Adrian, Desjardins, Jean-François, Lovren, Fina, Pan, Yi, Garg, Vinay, Gosal, Sumandeep, Garg, Ankit, Szmitko, Paul E., Schneider, Michael D., Parker, Thomas G., Stanford, William L., Leong-Poi, Howard, Teoh, Hwee, Al-Omran, Mohammed, Verma, Subodh

“…The tumor suppressor breast cancer susceptibility gene 2 (BRCA2) plays an important role in the repair of DNA damage, and loss of BRCA2 predisposes carriers to…”
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Cardiac Function in Mice Lacking the Glucagon-Like Peptide-1 Receptor by Gros, Robert, You, Xiaomang, Baggio, Laurie L, Kabir, M. Golam, Sadi, Al Muktafi, Mungrue, Imran N, Parker, Thomas G, Huang, Qingling, Drucker, Daniel J, Husain, Mansoor

“…Glucagon-like peptide-1 (GLP-1) acts via its G protein-coupled receptor (GLP-1R) to regulate blood glucose. Although the GLP-1R is widely expressed in…”
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Correction: Let-7, Mir-98 and Mir-181 as Biomarkers for Cancer and Schizophrenia by Rizos, Emmanouil, Siafakas, Nikolaos, Katsantoni, Eleni, Skourti, Eleni, Salpeas, Vassilios, Rizos, Ioannis, Tsoporis, James N, Kastania, Anastasia, Filippopoulou, Anastasia, Xiros, Nikolaos, Margaritis, Demetrios, Parker, Thomas G, Papageorgiou, Charalabos, Zoumpourlis, Vassilios

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S100A1: A Multifaceted Therapeutic Target in Cardiovascular Disease by Rohde, David, Ritterhoff, Julia, Voelkers, Mirko, Katus, Hugo A., Parker, Thomas G., Most, Patrick

“…Cardiovascular disease is the leading cause of death worldwide, showing a dramatically growing prevalence. It is still associated with a poor clinical…”
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Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat by YING TUNG SIA, LAPOINTE, Nathalie, ADAM, Albert, BUTANY, Jagdish, ROULEAU, Jean L, PARKER, Thomas G, TSOPORIS, James N, DESCHEPPER, Christian F, CALDERONE, Angelino, POURDJABBAR, A, JASMIN, J. F, SARRAZIN, J. F, LIU, Peter

“…Congestive heart failure (CHF) is a disease that is characterized by progressive left ventricular (LV) dysfunction and dilatation. Oxidative stress is thought…”
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Emerging markers of inflammation and oxidative stress as potential predictors of coronary artery disease by Tsirebolos, George, Tsoporis, James N., Drosatos, Ioannis-Alexandros, Izhar, Shehla, Gkavogiannakis, Nikolaos, Sakadakis, Eleftherios, Triantafyllis, Andreas S., Parker, Thomas G., Rallidis, Loukianos S., Rizos, Ioannis

“…The multi-ligand receptor for advanced glycation end products (RAGE) and its ligands AGEs and S100/calgranulin proteins are important mediators of inflammation…”
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Increased right atrial appendage apoptosis is associated with differential regulation of candidate MicroRNAs 1 and 133A in patients who developed atrial fibrillation after cardiac surgery by Tsoporis, James N., Fazio, Anastasia, Rizos, Ioannis K., Izhar, Shehla, Proteau, Gerald, Salpeas, Vasileos, Rigopoulos, Angelos, Sakadakis, Eleftherios, Toumpoulis, Ioannis K., Parker, Thomas G.

“…Atrial fibrillation (AF) following on-pump coronary artery bypass grafting (CABG) is a common condition associated with increased morbidity and mortality. We…”
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