Search Results - "PARKER, Robert S"

Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase by Sontag, Timothy J., Parker, Robert S.

“…Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial ω-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and…”
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In Vivo Fluorescence Detection of Glucose Using a Single-Walled Carbon Nanotube Optical Sensor:  Design, Fluorophore Properties, Advantages, and Disadvantages by Barone, Paul W, Parker, Robert S, Strano, Michael S

“…In this work, several aspects of in vivo glucose detection using a nanotube-based optical sensor are considered. The optical properties of commonly used…”
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Investigation of the Impact of Manufacturing Methods on Protein-Based Long-Acting Injectable Formulations: A Comparative Assessment for Microfluidics vs. Conventional Methods by Yonet-Tanyeri, Nihan, Parker, Robert S, Falo, Jr, Louis D, Little, Steven R

“…Microparticle-based drug delivery systems offer several advantages for protein-based drug formulations, enhancing patient compliance and therapeutic efficiency…”
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Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14 Gene) Causes Severe Perturbations in Vitamin E Metabolism by Bardowell, Sabrina A., Duan, Faping, Manor, Danny, Swanson, Joy E., Parker, Robert S.

“…Background: Human CYP4F2 metabolizes vitamin E, but its role in vivo is unknown. Results: Disruption of Cyp4f14, a murine ortholog of CYP4F2, severely alters…”
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Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism by Bardowell, Sabrina A., Ding, Xinxin, Parker, Robert S.

“…The widely conserved preferential accumulation of α-tocopherol (α-TOH) in tissues occurs, in part, from selective postabsorptive catabolism of non-α-TOH forms…”
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Elytra color as a signal of chemical defense in the Asian ladybird beetle Harmonia axyridis by Bezzerides, Alexander L, McGraw, Kevin J, Parker, Robert S, Husseini, Jad

“…Carotenoid- and melanin-based colors are valuable indicators of quality in many vertebrates, but their signaling role in invertebrates remains relatively…”
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Identification of Clinical Phenotypes in Septic Patients Presenting With Hypotension or Elevated Lactate by Aldewereld, Zachary T, Zhang, Li Ang, Urbano, Alisa, Parker, Robert S, Swigon, David, Banerjee, Ipsita, Gómez, Hernando, Clermont, Gilles

“…Targeted therapies for sepsis have failed to show benefit due to high variability among subjects. We sought to demonstrate different phenotypes of septic shock…”
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A physiologically-motivated compartment-based model of the effect of inhaled hypertonic saline on mucociliary clearance and liquid transport in cystic fibrosis by Markovetz, Matthew R, Corcoran, Timothy E, Locke, Landon W, Myerburg, Michael M, Pilewski, Joseph M, Parker, Robert S

“…Cystic Fibrosis (CF) lung disease is characterized by liquid hyperabsorption, airway surface dehydration, and impaired mucociliary clearance (MCC). Herein, we…”
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Nasal epithelial cell culture fluorescence recovery after photobleaching predicts cystic fibrosis therapeutic response by Corcoran, Timothy E, Bertrand, Carol A, Myerburg, Michael M, Weiner, Daniel J, Frizzell, Sheila A, Li, Anna, Agostini, Brittani, Parker, Robert S, Shapiro, Monica E, Muthukrishnan, Ashok, Hages, Nicholas D, Mulhern, Brian P, Pilewski, Joseph M

“…Human nasal epithelial (HNE) cells can be sampled noninvasively and cultured to provide a model of the airway epithelium that reflects cystic fibrosis (CF)…”
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Determining robust reaction kinetics from limited data by Ozbuyukkaya, Gizem, Parker, Robert S., Veser, Goetz

“…Accurate chemical kinetics are essential for reactor design and operation. However, despite recent advances in “big data” approaches, availability of kinetic…”
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Modeling sepsis-induced organ failure by Papadopoulos, Stefanos, Parker, Robert S., Clermont, Gilles

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Modeling blood urea nitrogen (BUN) dynamics to estimate dialysis adequacy by Lint, Annabelle, Parker, Robert S., Clermont, Gilles

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Reinforcement learning algorithm to improve intermittent hemodialysis by McLaverty, Brian, Parker, Robert S., Clermont, Gilles

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Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro by Frank, Jan, Budek, Alicja, Lundh, Torbjörn, Parker, Robert S., Swanson, Joy E., Lourenço, Cátia F., Gago, Bruno, Laranjinha, João, Vessby, Bengt, Kamal-Eldin, Afaf

“…To identify dietary phenolic compounds capable of improving vitamin E status, male Sprague-Dawley rats were fed for 4 weeks either a basal diet (control) with…”
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ω-Hydroxylation of α-tocopheryl quinone reveals a dual function for cytochrome P450-4F2 in vitamin E metabolism by Taylor, Luke, Krueger, Nick, Malysheva, Olga, Atkinson, Jeffrey, Parker, Robert S.

“…[Display omitted] α-Tocopherol (α-TOH) is the primary lipophilic radical trapping antioxidant in human tissues. Oxidative catabolism of α-tocopherol (αTOH) is…”
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Improvements and limitations in developing multivariate models of hemorrhage and transfusion risk for the obstetric population by Pressly, Michelle A., Parker, Robert S., Waters, Jonathan H., Beck, Stacy L., Jeyabalan, Arundhathi, Clermont, Gilles

“…Background Maternal hemorrhage protocols involve risk screening. These protocols prepare clinicians for potential hemorrhage and transfusion in individual…”
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Vitamin E secretion by Caco-2 monolayers to APOA1, but not to HDL, is vitamer selective by Nicod, Nathalie, Parker, Robert S

“…The aim of this study was to characterize the pathways of basolateral secretion of common dietary tocopherols from polarized Caco-2 monolayers, a model of…”
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The cytotoxicity of vitamin E is both vitamer- and cell-specific and involves a selectable trait by McCormick, Charles C, Parker, Robert S

“…During a study of the effect of vitamin E in activated mouse macrophages, we observed a reduction in the viability of cells treated with various forms of…”
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Accelerating availability of clinically-relevant parameter estimates from thromboelastogram point-of-care device by Pressly, Michelle A., Parker, Robert S., Neal, Matthew D., Sperry, Jason L., Clermont, Gilles

“…Modeling approaches offer a novel way to detect and predict coagulopathy in trauma patients. A dynamic model, built and tested on thromboelastogram (TEG) data,…”
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YOU CAN'T JUDGE A PIGMENT BY ITS COLOR: CAROTENOID AND MELANIN CONTENT OF YELLOW AND BROWN FEATHERS IN SWALLOWS, BLUEBIRDS, PENGUINS, AND DOMESTIC CHICKENS by McGraw, Kevin J, Wakamatsu, Kazumasa, Ito, Shosuke, Nolan, Paul M, Jouventin, Pierre, Dobson, F. Stephen, Austic, Richard E, Safran, Rebecca J, Siefferman, Lynn M, Hill, Geoffrey E, Parker, Robert S

“…The two main pigment types in bird feathers are the red, orange, and yellow carotenoids and the black, gray, and brown melanins. Reports conflict, however,…”
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