Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats

The nucleus accumbens (NAC) is theorized to be a critical element of the neural circuitry that mediates relapse to cocaine seeking. Evidence suggests that the NAC is a functionally heterogeneous structure, and the core (NACc) and shell (NACs) regions of the NAC may play a differential role in stimul...

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Published in:	Psychopharmacologia Vol. 176; no. 3-4; pp. 459 - 465
Main Authors:	FUCHS, Rita A, EVANS, K. Allison, PARKER, Macon C, SEE, Ronald E
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-11-2004 Springer Nature B.V
Subjects:	Acoustic Stimulation Animals Behavior Biological and medical sciences Cocaine Cocaine - administration & dosage Cocaine-Related Disorders - physiopathology Cocaine-Related Disorders - psychology Conditioning, Operant - physiology Cues Extinction, Psychological - drug effects Food Injections Laboratory animals Light Male Medical sciences Motor Activity - drug effects Neuropharmacology Nucleus Accumbens - physiopathology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Recurrence Self Administration United States > US Agonist Relapse Rat Psychotropic Self administration Conditioned stimuli Muscimol Gabaergic receptor Ester Antispasmodic agent Reinstatement Baclofen Drug of abuse Self-administration CNS stimulant Extinction Muscle relaxant Gabaergic agonist Rodentia Local anesthetic Nucleus accumbens Vertebrata Mammalia Animal Cocaine Gabaergic receptor B
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Summary:	The nucleus accumbens (NAC) is theorized to be a critical element of the neural circuitry that mediates relapse to cocaine seeking. Evidence suggests that the NAC is a functionally heterogeneous structure, and the core (NACc) and shell (NACs) regions of the NAC may play a differential role in stimulus-induced motivated behavior. Thus, determination of the involvement of NAC subregions in conditioned cue-induced reinstatement of cocaine seeking is warranted. The present study compared the effects of GABA agonist-induced inactivation of the NACc versus NACs on conditioned cue-induced reinstatement of cocaine seeking behavior. Rats were trained to lever press for cocaine infusions (0.20 mg/infusion, IV) paired with presentations of a light-tone stimulus complex. Responding was then allowed to extinguish prior to reinstatement testing. Reinstatement of cocaine seeking (i.e. responses on the previously cocaine-paired lever) was measured in the presence of response-contingent presentation of the light-tone stimulus complex following microinfusion of muscimol+baclofen (Mus+Bac, 0.1/1.0 mM, respectively, 0.3 microl/side) or vehicle into the NACc or NACs. The effects of these manipulations on locomotor activity were also examined. Mus+Bac-induced inactivation of the NACc abolished, whereas inactivation of the NACs failed to alter, conditioned cue-induced reinstatement of operant responding relative to vehicle pretreatment. Time course analyses of the effects of these manipulations on locomotion versus operant responding confirmed that the effects of Mus+Bac on reinstatement were not due to suppression of general activity. The functional integrity of the NACc, but not the NACs, is necessary for conditioned cue-induced reinstatement of cocaine seeking behavior.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0033-3158 1432-2072
DOI:	10.1007/s00213-004-1895-6