Search Results - "PARKER, Josie E"

The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus by Furukawa, Takanori, van Rhijn, Norman, Fraczek, Marcin, Gsaller, Fabio, Davies, Emma, Carr, Paul, Gago, Sara, Fortune-Grant, Rachael, Rahman, Sayema, Gilsenan, Jane Mabey, Houlder, Emma, Kowalski, Caitlin H., Raj, Shriya, Paul, Sanjoy, Cook, Peter, Parker, Josie E., Kelly, Steve, Cramer, Robert A., Latgé, Jean-Paul, Moye-Rowley, Scott, Bignell, Elaine, Bowyer, Paul, Bromley, Michael J.

“…The frequency of antifungal resistance, particularly to the azole class of ergosterol biosynthetic inhibitors, is a growing global health problem. Survival…”
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Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens by WARRILOW, Andrew G, PARKER, Josie E, KELLY, Diane E, KELLY, Steven L

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Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function by Fan, Jieru, Urban, Martin, Parker, Josie E., Brewer, Helen C., Kelly, Steven L., Hammond‐Kosack, Kim E., Fraaije, Bart A., Liu, Xili, Cools, Hans J.

“…CYP51 encodes the cytochrome P450 sterol 14α-demethylase, an enzyme essential for sterol biosynthesis and the target of azole fungicides. In Fusarium species,…”
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The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species by Xie, Jinhong, Rybak, Jeffrey M., Martin-Vicente, Adela, Guruceaga, Xabier, Thorn, Harrison I., Nywening, Ashley V., Ge, Wenbo, Parker, Josie E., Kelly, Steven L., Rogers, P. David, Fortwendel, Jarrod R.

“…Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane…”
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Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals by EDDOUZI, Jamel, PARKER, Josie E, VALE-SILVA, Luis A, COSTE, Alix, ISCHER, Françoise, KELLY, Steve, MANAI, Mohamed, SANGLARD, Dominique

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A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1 by Rybak, Jeffrey M., Xie, Jinhong, Martin-Vicente, Adela, Guruceaga, Xabier, Thorn, Harrison I., Nywening, Ashley V., Ge, Wenbo, Souza, Ana C. O., Shetty, Amol C., McCracken, Carrie, Bruno, Vincent M., Parker, Josie E., Kelly, Steven L., Snell, Hannah M., Cuomo, Christina A., Rogers, P. David, Fortwendel, Jarrod R.

“…Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis…”
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Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B by HULL, Claire M, PARKER, Josie E, BADER, Oliver, WEIG, Michael, GROSS, Uwe, WARRILOW, Andrew G. S, KELLY, Diane E, KELLY, Steven L

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Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis by Morgan, Siân R., Pilia, Nicole, Hewitt, Melissa, Moses, Rachael L., Moseley, Ryan, Lewis, Philip N., Morrison, Peter W.J., Kelly, Steven L., Parker, Josie E., Whitaker, David, Quantock, Andrew J., Heard, Charles M.

“…[Display omitted] Acanthamoeba keratitis is caused by a protozoal infection of the cornea, with 80% of cases involving the improper use of contact lenses. The…”
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Cytochrome P450 168A1 from Pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids by Price, Claire L, Warrilow, Andrew G S, Rolley, Nicola J, Parker, Josie E, Thoss, Vera, Kelly, Diane E, Corcionivoschi, Nicolae, Kelly, Steven L

“…The cytochrome P450 CYP168A1 from Pseudomonas aeruginosa was cloned and expressed in Escherichia coli followed by purification and characterization of…”
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Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans by MARTEL, Claire M, PARKER, Josie E, BADER, Oliver, WEIG, Michael, GROSS, Uwe, WARRILOW, Andrew G. S, ROLLEY, Nicola, KELLY, Diane E, KELLY, Steven L

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A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14α-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B by Martel, Claire M, Parker, Josie E, Bader, Oliver, Weig, Michael, Gross, Uwe, Warrilow, Andrew G S, Kelly, Diane E, Kelly, Steven L

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Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2 by HULL, Claire M, BADER, Oliver, PARKER, Josie E, WEIG, Michael, GROSS, Uwe, WARRILOW, Andrew G. S, KELLY, Diane E, KELLY, Steven L

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Impact of Recently Emerged Sterol 14α-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity by COOLS, Hans J, MULLINS, Jonathan G. L, FRAAIJE, Bart A, PARKER, Josie E, KELLY, Diane E, LUCAS, John A, KELLY, Steven L

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Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status by Regan, Jessica, DeJarnette, Christian, Luna-Tapia, Arturo, Parker, Josie E, Reitler, Parker, Barnett, Stacey, Tucker, Katie M, Kelly, Steven L, Palmer, Glen E

“…The azole antifungals inhibit sterol 14α-demethylase (S14DM), which depletes cellular ergosterol and promotes synthesis of the dysfunctional lipid…”
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Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14-α-Demethylase by PARKER, Josie E, WARRILOW, Andrew G. S, COOLS, Hans J, FRAAIJE, Bart A, LUCAS, John A, RIGDOVA, Katarina, GRIFFITHS, William J, KELLY, Diane E, KELLY, Steven L

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Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr by Asadzadeh, Mohammad, Alfouzan, Wadha, Parker, Josie E, Meis, Jacques F, Kelly, Steven L, Joseph, Leena, Ahmad, Suhail

“…The molecular basis of reduced susceptibility to amphotericin B (rs-AMB) among any yeasts is poorly defined. Genetic alterations in genes involved in…”
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Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B by WARRILOW, Andrew G. S, MELO, Nadja, MARTEL, Claire M, PARKER, Josie E, NES, W. David, KELLY, Steven L, KELLY, Diane E

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Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51) by WARRILOW, Andrew G. S, MARTEL, Claire M, PARKER, Josie E, MELO, Nadja, LAMB, David C, NES, W. David, KELLY, Diane E, KELLY, Steven L

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Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola by Mullins, Jonathan G L, Parker, Josie E, Cools, Hans J, Togawa, Roberto C, Lucas, John A, Fraaije, Bart A, Kelly, Diane E, Kelly, Steven L

“…A structural rationale for recent emergence of azole (imidazole and triazole) resistance associated with CYP51 mutations in the wheat pathogen Mycosphaerella…”
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Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals by Parker, Josie E, Warrilow, Andrew G.S, Cools, Hans J, Martel, Claire M, Nes, W. David, Fraaije, Bart A, Lucas, John A, Kelly, Diane E, Kelly, Steven L

“…Prothioconazole is one of the most important commercially available demethylase inhibitors (DMIs) used to treat Mycosphaerella graminicola infection of wheat,…”
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