Search Results - "PARKER, John S. L"

Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6 by Peralta, Santiago, Grenier, Jennifer K., Webb, Suzin M., Miller, Andrew D., Miranda, Ileana C., Parker, John S. L.

“…Feline chronic gingivostomatitis (FCGS) is a relatively common and debilitating disease characterized by bilateral inflammation and ulceration of the caudal…”
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Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles by Lee, Christopher H, Raghunathan, Krishnan, Taylor, Gwen M, French, Andrea J, Tenorio, Raquel, Fernández de Castro, Isabel, Risco, Cristina, Parker, John S L, Dermody, Terence S

“…The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances…”
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Spatial mapping of the total transcriptome by in situ polyadenylation by McKellar, David W., Mantri, Madhav, Hinchman, Meleana M., Parker, John S. L., Sethupathy, Praveen, Cosgrove, Benjamin D., De Vlaminck, Iwijn

“…Spatial transcriptomics reveals the spatial context of gene expression, but current methods are limited to assaying polyadenylated (A-tailed) RNA transcripts…”
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The Cellular Chaperone Hsc70 Is Specifically Recruited to Reovirus Viral Factories Independently of Its Chaperone Function by KAUFER, Susanne, COFFEY, Caroline M, PARKER, John S. L

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Identification of Regions and Residues in Feline Junctional Adhesion Molecule Required for Feline Calicivirus Binding and Infection by OSSIBOFF, Robert J, PARKER, John S. L

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Conformational Changes in the Capsid of a Calicivirus upon Interaction with Its Functional Receptor by Ossiboff, Robert J, Zhou, Yi, Lightfoot, Patrick J, Prasad, B V Venkataram, Parker, John S L

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Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates by Ossiboff, Robert J, Sheh, Alexander, Shotton, Justine, Pesavento, Patricia A, Parker, John S. L

“…1 Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA 2 Department of Pathology, Microbiology and…”
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The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection by Guo, Yingying, Parker, John S L

“…De novo viral protein synthesis following entry into host cells is essential for viral replication. As a consequence, viruses have evolved mechanisms to engage…”
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The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury by Guo, Yingying, Hinchman, Meleana M., Lewandrowski, Mercedes, Cross, Shaun T., Sutherland, Danica M., Welsh, Olivia L., Dermody, Terence S., Parker, John S. L.

“…The mammalian orthoreovirus double-stranded (ds) RNA-binding protein σ3 is a multifunctional protein that promotes viral protein synthesis and facilitates…”
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Virus-mediated compartmentalization of the host translational machinery by Desmet, Emily A, Anguish, Lynne J, Parker, John S L

“…Viruses require the host translational apparatus to synthesize viral proteins. Host stress response mechanisms that suppress translation, therefore, represent…”
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Reovirus Nonstructural Protein μNS Recruits Viral Core Surface Proteins and Entering Core Particles to Factory-Like Inclusions by BROERING, Teresa J, KIM, Jonghwa, MILLER, Cathy L, PIGGOTT, Caroline D. S, DINOSO, Jason B, NIBERT, Max L, PARKER, John S. L

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Micro-total analysis system for virus detection: microfluidic pre-concentration coupled to liposome-based detection by Connelly, John T., Kondapalli, Sowmya, Skoupi, Marc, Parker, John S. L., Kirby, Brian J., Baeumner, Antje J.

“…An integrated microfluidic biosensor is presented that combines sample pre-concentration and liposome-based signal amplification for the detection of enteric…”
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The Natural Host Range Shift and Subsequent Evolution of Canine Parvovirus Resulted from Virus-Specific Binding to the Canine Transferrin Receptor by Hueffer, Karsten, Parker, John S L, Weichert, Wendy S, Geisel, Rachel E, Sgro, Jean-Yves, Parrish, Colin R

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Mammalian orthoreovirus Infection is Enhanced in Cells Pre-Treated with Sodium Arsenite by Lutz, 4th, Michael M, Worth, Megan P, Hinchman, Meleana M, Parker, John S L, Ledgerwood, Emily D

“…Following reovirus infection, cells activate stress responses that repress canonical translation as a mechanism to limit progeny virion production. Work by…”
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Reovirus Infection or Ectopic Expression of Outer Capsid Protein μ1 Induces Apoptosis Independently of the Cellular Proapoptotic Proteins Bax and Bak by WISNIEWSKI, Meagan L, WERNER, Brenda G, HOM, Louis G, ANGUISH, Lynne J, COFFEY, Caroline M, PARKER, John S. L

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Putative Autocleavage of Outer Capsid Protein μ1, Allowing Release of Myristoylated Peptide μ1N during Particle Uncoating, Is Critical for Cell Entry by Reovirus by ODEGARD, Amy L, CHANDRAN, Kartik, XING ZHANG, PARKER, John S. L, BAKER, Timothy S, NIBERT, Max L

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A Proapoptotic Peptide Derived from Reovirus Outer Capsid Protein μ1 Has Membrane-Destabilizing Activity by KIM, Jae-Won, LYI, Sangbom M, PARRISH, Colin R, PARKER, John S. L

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Reovirus Infection or Ectopic Expression of Outer Capsid Protein mu 1 Induces Apoptosis Independently of the Cellular Proapoptotic Proteins Bax and Bak by Wisniewski, Meagan L, Werner, Brenda G, Hom, Louis G, Anguish, Lynne J, Coffey, Caroline M, Parker, John SL

“…Mammalian orthoreoviruses induce apoptosis in vivo and in vitro; however, the specific mechanism by which apoptosis is induced is not fully understood. Recent…”
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Fluorescent protein tags affect the condensation properties of a phase-separating viral protein by Barkley, Russell J R, Crowley, Jack C, Brodrick, Andrew J, Zipfel, Warren R, Parker, John S L

“…Fluorescent protein (FP) tags are extensively used to visualize and characterize the properties of biomolecular condensates despite a lack of investigation…”
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Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cells by Saikia, Mridusmita, Burnham, Philip, Keshavjee, Sara H., Wang, Michael F. Z., Heyang, Michael, Moral-Lopez, Pablo, Hinchman, Meleana M., Danko, Charles G., Parker, John S. L., De Vlaminck, Iwijn

“…We describe droplet-assisted RNA targeting by single-cell sequencing (DART-seq), a versatile technology that enables multiplexed amplicon sequencing and…”
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