Search Results - "PARK, Sungdae"

CRISPR-Cas9 Gene Editing in Lizards through Microinjection of Unfertilized Oocytes by Rasys, Ashley M., Park, Sungdae, Ball, Rebecca E., Alcala, Aaron J., Lauderdale, James D., Menke, Douglas B.

“…CRISPR-Cas9-mediated gene editing has enabled the direct manipulation of gene function in many species. However, the reproductive biology of reptiles presents…”
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Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer by GANG REN, BARITAKI, Stavroula, DAIGNAULT, Stephanie, AL-MULLA, Fahd, KELLER, Evan, BONAVIDA, Ben, DE LA SERNA, Ivana, YEUNG, Kam C, MARATHE, Himangi, JINGWEI FENG, PARK, Sungdae, BEACH, Sandy, BAZELEY, Peter S, BESHIR, Anwar B, FENTEANY, Gabriel, MEHRA, Rohit

“…Epigenetic modifications such as histone methylation play an important role in human cancer metastasis. Enhancer of zeste homolog 2 (EZH2), which encodes the…”
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Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a by Ching, Saunders T, Infante, Carlos R, Du, Wen, Sharir, Amnon, Park, Sungdae, Menke, Douglas B, Klein, Ophir D

“…Abstract Genital malformations are among the most common human birth defects, and both genetic and environmental factors can contribute to these malformations…”
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A PAGE screening approach for identifying CRISPR-Cas9-induced mutations in zebrafish by VanLeuven, Ariel J, Park, Sungdae, Menke, Douglas B, Lauderdale, James D

“…The introduction of CRISPR-Cas9 technology for targeted mutagenesis has revolutionized reverse genetics and made genome editing a realistic option in many…”
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Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species by Domyan, Eric T, Kronenberg, Zev, Infante, Carlos R, Vickrey, Anna I, Stringham, Sydney A, Bruders, Rebecca, Guernsey, Michael W, Park, Sungdae, Payne, Jason, Beckstead, Robert B, Kardon, Gabrielle, Menke, Douglas B, Yandell, Mark, Shapiro, Michael D

“…Birds display remarkable diversity in the distribution and morphology of scales and feathers on their feet, yet the genetic and developmental mechanisms…”
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A new model for raf kinase inhibitory protein induced chemotherapeutic resistance by Al-Mulla, Fahd, Bitar, Milad S, Feng, Jingwei, Park, Sungdae, Yeung, Kam C

“…Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of…”
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Chromosome-scale genome assembly of the brown anole (Anolis sagrei), an emerging model species by Geneva, Anthony J., Park, Sungdae, Bock, Dan G., de Mello, Pietro L. H., Sarigol, Fatih, Tollis, Marc, Donihue, Colin M., Reynolds, R. Graham, Feiner, Nathalie, Rasys, Ashley M., Lauderdale, James D., Minchey, Sergio G., Alcala, Aaron J., Infante, Carlos R., Kolbe, Jason J., Schluter, Dolph, Menke, Douglas B., Losos, Jonathan B.

“…Rapid technological improvements are democratizing access to high quality, chromosome-scale genome assemblies. No longer the domain of only the most highly…”
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Reduction of Ethyl Benzoylacetate and Selective Protection of 2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol: A New and Facile Synthesis of Tolterodine by De Castro, Kathlia A, Ko, Jungnam, Park, Daejong, Park, Sungdae, Rhee, Hakjune

“…A new and facile synthesis of tolterodine using ethyl benzoylacetate as the starting material was developed. Reduction using sodium borohydride in methanol…”
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Regulation of RKIP binding to the N-region of the Raf-1 kinase by Park, Sungdae, Rath, Oliver, Beach, Sandy, Xiang, Xiaoqin, Kelly, Sharon M., Luo, Zhijun, Kolch, Walter, Yeung, Kam C.

“…The Raf kinase inhibitory protein (RKIP) binds to Raf-1 interfering with binding of the MEK substrate and potentially also Raf-1 activation. In response to…”
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Nucleotide-Dependent Conformational Changes in the σ54-Dependent Activator DctD by Wang, Ying-Kai, Park, Sungdae, Nixon, B. Tracy, Hoover, Timothy R.

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets by Wang, Jialiang S., Infante, Carlos R., Park, Sungdae, Menke, Douglas B.

“…The PITX1 transcription factor is expressed during hindlimb development, where it plays a critical role in directing hindlimb growth and the specification of…”
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Changes in selection pressure can facilitate hybridization during biological invasion in a Cuban lizard by Bock, Dan G., Baeckens, Simon, Pita-Aquino, Jessica N., Chejanovski, Zachary A., Michaelides, Sozos N., Muralidhar, Pavitra, Lapiedra, Oriol, Park, Sungdae, Menke, Douglas B., Geneva, Anthony J., Losos, Jonathan B., Kolbe, Jason J.

“…Hybridization is among the evolutionary mechanisms most frequently hypothesized to drive the success of invasive species, in part because hybrids are common in…”
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Using Mouse Metatarsal and Pisiform Ossification to Identify Genes Underlying Growth Plate Formation by Reno, Philip L., Kjosness, Kelsey M., Park, Sungdae, Fared, Daved, Stubblebine, Mallory B., Fitzwater, Meghan T., Menke, Douglas B.

“…Variation in growth rate underlies, in large part, the great diversity in mammalian skeletal shape. Longitudinal growth occurs at growth plates, which amplify…”
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Pigeon foot feathering reveals conserved limb identity networks by Boer, Elena F., Van Hollebeke, Hannah F., Park, Sungdae, Infante, Carlos R., Menke, Douglas B., Shapiro, Michael D.

“…The tetrapod limb is a stunning example of evolutionary diversity, with dramatic variation not only among distantly related species, but also between the…”
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RKIP inhibits NF-κB in cancer cells by regulating upstream signaling components of the IκB kinase complex by Tang, Huihui, Park, Sungdae, Sun, Shao-Cong, Trumbly, Robert, Ren, Gang, Tsung, Eric, Yeung, Kam C.

“…RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-κB pathway. Genetic and…”
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Shared Enhancer Activity in the Limbs and Phallus and Functional Divergence of a Limb-Genital cis-Regulatory Element in Snakes by Infante, Carlos R., Mihala, Alexandra G., Park, Sungdae, Wang, Jialiang S., Johnson, Kenji K., Lauderdale, James D., Menke, Douglas B.

“…The amniote phallus and limbs differ dramatically in their morphologies but share patterns of signaling and gene expression in early development. Thus far, the…”
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A PAGE screening approach for identifying CRISPR-Cas9-induced mutations in zebrafi sh by VanLeuven, Ariel J, Park, Sungdae, Menke, Douglas B, Lauderdale, James D

“…The introduction of CRISPR-Cas9 technology for targeted mutagenesis has revolutionized reverse genetics and made genome editing a realistic option in many…”
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Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements by Infante, Carlos R., Park, Sungdae, Mihala, Alexandra G., Kingsley, David M., Menke, Douglas B.

“…Extensive functional analyses have demonstrated that the pituitary homeodomain transcription factor Pitx1 plays a critical role in specifying hindlimb…”
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A single locus regulates a female-limited color pattern polymorphism in a reptile by Feiner, Nathalie, Brun-Usan, Miguel, Andrade, Pedro, Pranter, Robin, Park, Sungdae, Menke, Douglas B, Geneva, Anthony J, Uller, Tobias

“…Animal coloration is often expressed in periodic patterns that can arise from differential cell migration, yet how these processes are regulated remains…”
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Snail is a repressor of RKIP transcription in metastatic prostate cancer cells by Beach, S, Tang, H, Park, S, Dhillon, A S, Keller, E T, Kolch, W, Yeung, K C

“…Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown. Here,…”
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