Search Results - "PARK, David"

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program by Khacho, Mireille, Clark, Alysen, Svoboda, Devon S., Azzi, Joelle, MacLaurin, Jason G., Meghaizel, Cynthia, Sesaki, Hiromi, Lagace, Diane C., Germain, Marc, Harper, Mary-Ellen, Park, David S., Slack, Ruth S.

“…Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion and aging. While mitochondrial morphology plays a fundamental role in…”
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Tribute to the Voluntarist Ethos of New Media & Society: A Farewell by Park, David W

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Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease by Kim, Kwang Soo, Marcogliese, Paul C., Yang, Jungwoo, Callaghan, Steve M., Resende, Virginia, Abdel-Messih, Elizabeth, Marras, Connie, Visanji, Naomi P., Huang, Jana, Schlossmacher, Michael G., Trinkle-Mulcahy, Laura, Slack, Ruth S., Lang, Anthony E., Park, David S.

“…Leucine-rich repeat kinase 2 (LRRK2) has been implicated in both familial and sporadic Parkinson’s disease (PD), yet its pathogenic role remains unclear. A…”
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Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit by Yang, Jing, Wu, Zhuhao, Renier, Nicolas, Simon, David J., Uryu, Kunihiro, Park, David S., Greer, Peter A., Tournier, Cathy, Davis, Roger J., Tessier-Lavigne, Marc

“…Axonal death disrupts functional connectivity of neural circuits and is a critical feature of many neurodegenerative disorders. Pathological axon degeneration…”
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The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin by Chorin, Ehud, Dai, Matthew, Shulman, Eric, Wadhwani, Lalit, Bar-Cohen, Roi, Barbhaiya, Chirag, Aizer, Anthony, Holmes, Douglas, Bernstein, Scott, Spinelli, Michael, Park, David S., Chinitz, Larry A., Jankelson, Lior

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Programmed cell death in Parkinson's disease by Venderova, Katerina, Park, David S

“…Parkinson's disease is a debilitating disorder characterized by a progressive loss of dopaminergic neurons caused by programmed cell death. The aim of this…”
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COVID-19 market disruptions and food security: Evidence from households in rural Liberia and Malawi by Aggarwal, Shilpa, Jeong, Dahyeon, Kumar, Naresh, Park, David Sungho, Robinson, Jonathan, Spearot, Alan

“…We use data collected from panel phone surveys to document the changes in food security of households in rural Liberia and Malawi during the market disruptions…”
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QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin by Chorin, Ehud, Wadhwani, Lalit, Magnani, Silvia, Dai, Matthew, Shulman, Eric, Nadeau-Routhier, Charles, Knotts, Robert, Bar-Cohen, Roi, Kogan, Edward, Barbhaiya, Chirag, Aizer, Anthony, Holmes, Douglas, Bernstein, Scott, Spinelli, Michael, Park, David S., Stefano, Carugo, Chinitz, Larry A., Jankelson, Lior

“…There is no known effective therapy for patients with coronavirus disease 2019 (COVID-19). Initial reports suggesting the potential benefit of…”
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Posttransplant T lymphoblastic lymphoma mimicking Burkitt lymphoma by Mass, Jirong, Park, David C.

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Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment by Greene, Andrew W, Grenier, Karl, Aguileta, Miguel A, Muise, Stephanie, Farazifard, Rasoul, Haque, M Emdadul, McBride, Heidi M, Park, David S, Fon, Edward A

“…Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause recessively inherited Parkinson's disease (PD), a neurodegenerative disorder…”
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Myocardial infarction accelerates breast cancer via innate immune reprogramming by Koelwyn, Graeme J., Newman, Alexandra A. C., Afonso, Milessa S., van Solingen, Coen, Corr, Emma M., Brown, Emily J., Albers, Kathleen B., Yamaguchi, Naoko, Narke, Deven, Schlegel, Martin, Sharma, Monika, Shanley, Lianne C., Barrett, Tessa J., Rahman, Karishma, Mezzano, Valeria, Fisher, Edward A., Park, David S., Newman, Jonathan D., Quail, Daniela F., Nelson, Erik R., Caan, Bette J., Jones, Lee W., Moore, Kathryn J.

“…Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity 1 or surgery 2 , alters cancer pathogenesis. Patients with cancer,…”
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OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand by Patten, David A, Wong, Jacob, Khacho, Mireille, Soubannier, Vincent, Mailloux, Ryan J, Pilon-Larose, Karine, MacLaurin, Jason G, Park, David S, McBride, Heidi M, Trinkle-Mulcahy, Laura, Harper, Mary-Ellen, Germain, Marc, Slack, Ruth S

“…Cristae, the organized invaginations of the mitochondrial inner membrane, respond structurally to the energetic demands of the cell. The mechanism by which…”
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Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA by Galehdar, Zohreh, Swan, Patrick, Fuerth, Benjamin, Callaghan, Steven M, Park, David S, Cregan, Sean P

“…An increasing body of evidence points to a key role of endoplasmic reticulum (ER) stress in acute and chronic neurodegenerative conditions. Extensive ER stress…”
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Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review by Lee, Keum Hwa, Kronbichler, Andreas, Park, David Duck-Young, Park, YoungMin, Moon, Hanwool, Kim, Hyungdo, Choi, Jun Hyug, Choi, YoungSeo, Shim, Songjoo, Lyu, Il Suk, Yun, Byung Hwan, Han, Yeonseung, Lee, Donghee, Lee, Sang Yoon, Yoo, Byung Hun, Lee, Kyung Hwan, Kim, Tai Lim, Kim, Heonki, Shim, Joo Sung, Nam, Wonseok, So, Heesung, Choi, SooYeon, Lee, Sangmok, Shin, Jae Il

“…Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of…”
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Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis by Khacho, Mireille, Clark, Alysen, Svoboda, Devon S, MacLaurin, Jason G, Lagace, Diane C, Park, David S, Slack, Ruth S

“…Mitochondrial dysfunction is a common feature of many genetic disorders that target the brain and cognition. However, the exact role these organelles play in…”
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Red state, blue state, rich state, poor state: why americans vote the way they do. by Gelman, Andrew

“…On the night of the 2000 presidential election, Americans sat riveted in front of their televisions as polling results divided the nation’s map into red and…”
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Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy by Xilouri, Maria, Vogiatzi, Tereza, Vekrellis, Kostas, Park, David, Stefanis, Leonidas

“…The mechanisms through which aberrant alpha-synuclein (ASYN) leads to neuronal death in Parkinson's disease (PD) are uncertain. In isolated liver lysosomes,…”
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PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress by Huang, En, Qu, Dianbo, Huang, Tianwen, Rizzi, Nicoletta, Boonying, Wassamon, Krolak, Dorothy, Ciana, Paolo, Woulfe, John, Klein, Christine, Slack, Ruth S., Figeys, Daniel, Park, David S.

“…Mutations in PTEN-induced kinase 1 (PINK1) result in a recessive familial form of Parkinson’s disease (PD). PINK1 loss is associated with mitochondrial Ca 2+…”
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β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease by Mittal, Shuchi, Bjørnevik, Kjetil, Im, Doo Soon, Flierl, Adrian, Dong, Xianjun, Locascio, Joseph J., Abo, Kristine M., Long, Elizabeth, Jin, Ming, Xu, Bing, Xiang, Yang K., Rochet, Jean-Christophe, Engeland, Anders, Rizzu, Patrizia, Heutink, Peter, Bartels, Tim, Selkoe, Dennis J., Caldarone, Barbara J., Glicksman, Marcie A., Khurana, Vikram, Schüle, Birgitt, Park, David S., Riise, Trond, Scherzer, Clemens R.

“…Copy number mutations implicate excess production of α-synuclein as a possibly causative factor in Parkinson’s disease (PD). Using an unbiased screen targeting…”
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Combined oral 5-azacytidine and romidepsin are highly effective in patients with PTCL: a multicenter phase 2 study by Falchi, Lorenzo, Ma, Helen, Klein, Sandra, Lue, Jennifer K., Montanari, Francesca, Marchi, Enrica, Deng, Changchun, Kim, Hye A., Rada, Aishling, Jacob, Alice T., Kinahan, Cristina, Francescone, Mark M., Soderquist, Craig R., Park, David C., Bhagat, Govind, Nandakumar, Renu, Menezes, Daniel, Scotto, Luigi, Sokol, Lubomir, Shustov, Andrei R., O'Connor, Owen A.

“…Peripheral T-cell lymphomas (PTCLs) are uniquely vulnerable to epigenetic modifiers. We demonstrated in vitro synergism between histone deacetylase inhibitors…”
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