Search Results - "PARIS, Hervé"

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes by Bouvier, Michel, Galés, Céline, Van Durm, Joost J J, Schaak, Stéphane, Pontier, Stéphanie, Percherancier, Yann, Audet, Martin, Paris, Hervé

“…Activation of heterotrimeric G proteins by their cognate seven transmembrane domain receptors is believed to involve conformational changes propagated from the…”
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Deciphering biased-agonism complexity reveals a new active AT1 receptor entity by Saulière, Aude, Bellot, Morgane, Paris, Hervé, Denis, Colette, Finana, Frédéric, Hansen, Jonas T, Altié, Marie-Françoise, Seguelas, Marie-Hélène, Pathak, Atul, Hansen, Jakob L, Sénard, Jean-Michel, Galés, Céline

“…BRET probes that monitor activation of multiple G protein isoforms reveal that angiotensin II and a biased agonist of the angiotensin II type 1A receptor…”
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Might Adrenergic α2C-Agonists/α2A-Antagonists Become Novel Therapeutic Tools for Pain Treatment with Morphine? by Cardinaletti, Claudia, Mattioli, Laura, Ghelfi, Francesca, Del Bello, Fabio, Giannella, Mario, Bruzzone, Ariana, Paris, Hervé, Perfumi, Marina, Piergentili, Alessandro, Quaglia, Wilma, Pigini, Maria

“…The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided…”
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EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by α2A-adrenoreceptor in intestinal epithelial cells : A role in wound healing by BUFFIN-MEYER, Bénédicte, CRASSOUS, Pierre-Antoine, DELAGE, Christine, DENIS, Colette, SCHAAK, Stéphane, PARIS, Hervé

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Identification of a novel 12-nucleotide insertion polymorphism in the promoter region of ADRA2B: Full linkage with the 9-nucleotide deletion in the coding region and influence on transcriptional activity by Crassous, Pierre-Antoine, Blaise, Régis, Marquette, Amélie, Snapir, Amir, Scheinin, Mika, Paris, Hervé, Schaak, Stéphane

“…The α2B-adrenoceptor (α2B-AR) mediates vasoconstriction and a common polymorphism (+901 Ins/Del), located in the coding region of the human α2B-AR gene…”
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α₂-Adrenergic receptors activate cyclic AMP-response element-binding protein through arachidonic acid metabolism and protein kinase A in a subtype-specific manner by Karkoulias, Georgios, Mastrogianni, Orthodoxia, Papathanasopoulos, Panagiotis, Paris, Hervé, Flordellis, Christodoulos

“…On incubation with epinephrine, PC12 cells stably expressing α₂-adrenergic receptor (α₂-AR) undergo morphological and biochemical changes characteristic of…”
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α2B-Adrenergic Receptor Activates MAPK via a Pathway Involving Arachidonic Acid Metabolism, Matrix Metalloproteinases, and Epidermal Growth Factor Receptor Transactivation by Cussac, Daniel, Schaak, Stéphane, Denis, Colette, Paris, Hervé

“…We have investigated the mechanisms whereby α2B-adrenergic receptor (α2B-AR) promotes MAPK activation in a clone of the renal tubular cell line, LLC-PK1,…”
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Genetic variation of human adrenergic receptors: from molecular and functional properties to clinical and pharmacogenetic implications by Schaak, Stéphane, Mialet-Perez, Jeanne, Flordellis, Christodoulos, Paris, Hervé

“…Adrenergic receptors (ARs) are directly or indirectly involved in the control of a large panel of physiological functions and are the targets of drugs for the…”
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Rethinking target discovery in polygenic diseases by Flordellis, Christodoulos S, Manolis, Antonis S, Paris, Hervé, Karabinis, Andreas

“…Despite an extraordinary investment in R&D the yield of successful new drugs has been disproportionately low in recent years, suggesting that the whole process…”
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Clinical and pharmacological significance of α2-adrenoceptor polymorphisms in cardiovascular diseases by Flordellis, Christodoulos, Manolis, Antonios, Scheinin, Mika, Paris, Hervé

“…The α2-adrenoceptors (α2-ARs) are receptors for endogenous catecholamines (norepinephrine and epinephrine) that mediate a number of physiological and…”
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Expression of NOS1 and soluble guanylyl cyclase by human kidney epithelial cells: Morphological evidence for an autocrine/paracrine action of nitric oxide by Jarry, Anne, Renaudin, Karine, Denis, Marc G., Robard, Myriam, Buffin-Meyer, Bénédicte, Karam, Georges, Buzelin, Françoise, Paris, Hervé, Laboisse, Christian L., Vallette, Geneviève

“…Expression of NOS1 and soluble guanylyl cyclase by human kidney epithelial cells: Morphological evidence for an autocrine/paracrine action of nitric oxide…”
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The shift in the "paradigm" of the pharmacology of hypertension by Flordellis, Christodoulos S, Goumenos, Dimitrios, Kourounis, George, Tsementzis, Sotirios A, Paris, Hervé, Vlachojiannis, Jaannis

“…Until recently elevated blood pressure was considered as a hemodynamic entity representing an increase in workload for the heart and the arterial tree. Control…”
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HIGH-RESOLUTION ULTRAVIOLET RADIATION FIELDS OF CLASSICAL T TAURI STARS by France, Kevin, Schindhelm, Eric, Bergin, Edwin A, Roueff, Evelyne, Abgrall, Herve

“…ABSTRACT The far-ultraviolet (FUV; 912–1700 Å) radiation field from accreting central stars in classical T Tauri systems influences the disk chemistry during…”
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Induction of Intracellular Calcium Concentration by Environmental Benzo(a)pyrene Involves a β2-Adrenergic Receptor/Adenylyl Cyclase/Epac-1/Inositol 1,4,5-Trisphosphate Pathway in Endothelial Cells by Mayati, Abdullah, Levoin, Nicolas, Paris, Hervé, N'Diaye, Monique, Courtois, Arnaud, Uriac, Philippe, Lagadic-Gossmann, Dominique, Fardel, Olivier, Le Ferrec, Eric

“…Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl…”
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Alpha2-Adrenergic Receptors in Intestinal Epithelial Cells: Mechanisms of Signaling, Role, and Regulation by Paris, Herve, Coattrieux, Christelle, Crassous, Pierre Antoine, Denis, Collette, Buffin-Meyer, Benedicte, Cussac, Daniel, Schaak, Stephane

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[alpha]2-Adrenergic receptors activate cyclic AMP-response element-binding protein through arachidonic acid metabolism and protein kinase A in a subtype-specific manner by Karkoulias, Georgios, Mastrogianni, Orthodoxia, Papathanasopoulos, Panagiotis, Paris, Hervé, Flordellis, Christodoulos

“…On incubation with epinephrine, PC12 cells stably expressing [alpha]2-adrenergic receptor ([alpha]2-AR) undergo morphological and biochemical changes…”
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Alpha2-adrenergic receptors activate cyclic AMP-response element-binding protein through arachidonic acid metabolism and protein kinase A in a subtype-specific manner by Karkoulias, Georgios, Mastrogianni, Orthodoxia, Papathanasopoulos, Panagiotis, Paris, Hervé, Flordellis, Christodoulos

“…On incubation with epinephrine, PC12 cells stably expressing alpha2-adrenergic receptor (alpha2-AR) undergo morphological and biochemical changes…”
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α 2 ‐Adrenergic receptors activate cyclic AMP‐response element‐binding protein through arachidonic acid metabolism and protein kinase A in a subtype‐specific manner by Karkoulias, Georgios, Mastrogianni, Orthodoxia, Papathanasopoulos, Panagiotis, Paris, Hervé, Flordellis, Christodoulos

“…Abstract On incubation with epinephrine, PC12 cells stably expressing α 2 ‐adrenergic receptor (α 2 ‐AR) undergo morphological and biochemical changes…”
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The polymorphic deleted-form of the human α 2B -adrenergic receptor and its wild-type counterpart display post-receptor signaling pathway differences in LLC-PK1 cells by Mastrogianni, Orthodoxia, Crassous, Pierre-Antoine, Karkoulias, Georgios, Lykouras, Dimosthenis, Schaak, Stéphane, Patsouras, Nicholas, Panayiotakopoulos, George, Sivolapenko, Gregory, Paris, Hervé, Manolis, Antonis S, Flordellis, Christodoulos

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The polymorphic deleted-form of the human α2B-adrenergic receptor and its wild-type counterpart display post-receptor signaling pathway differences in LLC-PK1 cells by Mastrogianni, Orthodoxia, Crassous, Pierre-Antoine, Karkoulias, Georgios, Lykouras, Dimosthenis, Schaak, Stéphane, Patsouras, Nicholas, Panayiotakopoulos, George, Sivolapenko, Gregory, Paris, Hervé, Manolis, Antonis S., Flordellis, Christodoulos

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