Search Results - "PARIKH, HEMANG M."

Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection by Lin, Jake, Moradi, Elaheh, Salenius, Karoliina, Lehtipuro, Suvi, Häkkinen, Tomi, Laiho, Jutta E., Oikarinen, Sami, Randelin, Sofia, Parikh, Hemang M., Krischer, Jeffrey P., Toppari, Jorma, Lernmark, Åke, Petrosino, Joseph F., Ajami, Nadim J., She, Jin-Xiong, Hagopian, William A., Rewers, Marian J., Lloyd, Richard E., Rautajoki, Kirsi J., Hyöty, Heikki, Nykter, Matti

“…Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to…”
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High-throughput muscle fiber typing from RNA sequencing data by Oskolkov, Nikolay, Santel, Malgorzata, Parikh, Hemang M, Ekström, Ola, Camp, Gray J, Miyamoto-Mikami, Eri, Ström, Kristoffer, Mir, Bilal Ahmad, Kryvokhyzha, Dmytro, Lehtovirta, Mikko, Kobayashi, Hiroyuki, Kakigi, Ryo, Naito, Hisashi, Eriksson, Karl-Fredrik, Nystedt, Björn, Fuku, Noriyuki, Treutlein, Barbara, Pääbo, Svante, Hansson, Ola

“…Skeletal muscle fiber type distribution has implications for human health, muscle function, and performance. This knowledge has been gathered using…”
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Relationship between insulin sensitivity and gene expression in human skeletal muscle by Parikh, Hemang M, Elgzyri, Targ, Alibegovic, Amra, Hiscock, Natalie, Ekström, Ola, Eriksson, Karl-Fredrik, Vaag, Allan, Groop, Leif C, Ström, Kristoffer, Hansson, Ola

“…Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts…”
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Identification of type 1 diabetes risk phenotypes using an outcome-guided clustering analysis by You, Lu, Ferrat, Lauric A., Oram, Richard A., Parikh, Hemang M., Steck, Andrea K., Krischer, Jeffrey, Redondo, Maria J.

“…Aims/hypothesis Although statistical models for predicting type 1 diabetes risk have been developed, approaches that reveal the heterogeneity of the at-risk…”
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Oral Insulin Delay of Stage 3 Type 1 Diabetes Revisited in HLA DR4-DQ8 Participants in the TrialNet Oral Insulin Prevention Trial (TN07) by Zhao, Lue Ping, Papadopoulos, George K, Skyler, Jay S, Parikh, Hemang M, Kwok, William W, Bondinas, George P, Moustakas, Antonis K, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C, Geraghty, Daniel E, Lernmark, Åke

“…To explore if oral insulin could delay onset of stage 3 type 1 diabetes (T1D) among patients with stage 1/2 who carry HLA DR4-DQ8 and/or have elevated levels…”
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155-OR: Genetic Variation and Time to Progression in TN10 (Teplizumab) by MICHALEK, DOMINIKA A., ONENGUT-GUMUSCU, SUNA, CHEN, WEI-MIN, BRUSKO, TODD M., STECK, ANDREA, GOTTLIEB, PETER, ORAM, RICHARD A., KRISCHER, JEFFREY, PARIKH, HEMANG M., REDONDO, MARIA J., HEROLD, KEVAN C., RICH, STEPHEN S.

“…Introduction & Objective: TN10 Anti-CD3 Prevention (TN10) was a randomized phase 2 clinical trial that showed teplizumab delayed progression to type 1 diabetes…”
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Genetic Associations with C-peptide Levels before Type 1 Diabetes Diagnosis in At-Risk Relatives by Triolo, Taylor M, Parikh, Hemang M, Tosur, Mustafa, Ferrat, Lauric, You, Lu, Gottlieb, Peter A, Oram, Richard A, Onengut-Gumuscu, Suna, Krischer, Jeffrey P, Rich, Stephen S, Steck, Andrea K, Redondo, Maria J

“…We sought to determine whether the type 1 diabetes genetic risk score-2 (T1D-GRS2) and single nucleotide polymorphisms (SNPs) are associated with C-peptide…”
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1254-P: Genetic Prediction of C-Peptide Trajectory before Type 1 Diabetes Diagnosis in TrialNet by TRIOLO, TAYLOR M., PARIKH, HEMANG M., TOSUR, MUSTAFA, GOTTLIEB, PETER, ORAM, RICHARD A., ONENGUT-GUMUSCU, SUNA, KRISCHER, JEFFREY, RICH, STEPHEN S., STECK, ANDREA, REDONDO, MARIA J.

“…Modeling the course of C-peptide decline in autoantibody (Ab) positive individuals is important for type 1 diabetes (T1D) prediction and implementation of T1D…”
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HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07) by Zhao, Lue Ping, Papadopoulos, George K, Skyler, Jay S, Pugliese, Alberto, Parikh, Hemang M, Kwok, William W, Lybrand, Terry P, Bondinas, George P, Moustakas, Antonis K, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C, Geraghty, Daniel E, Lernmark, Åke

“…To explore associations of HLA class II genes (HLAII) with the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D)…”
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Data Mining Framework for Discovering and Clustering Phenotypes of Atypical Diabetes by Parikh, Hemang M, Remedios, Cassandra L, Hampe, Christiane S, Balasubramanyam, Ashok, Fisher-Hoch, Susan P, Choi, Ye Ji, Patel, Sanjeet, McCormick, Joseph B, Redondo, Maria J, Krischer, Jeffrey P

“…Abstract Context Some individuals present with forms of diabetes that are “atypical” (AD), which do not conform to typical features of either type 1 diabetes…”
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Progression to type 1 diabetes in the DPT-1 and TN07 clinical trials is critically associated with specific residues in HLA-DQA1-B1 heterodimers by Zhao, Lue Ping, Papadopoulos, George K., Skyler, Jay S., Pugliese, Alberto, Parikh, Hemang M., Kwok, William W., Lybrand, Terry P., Bondinas, George P., Moustakas, Antonis K., Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Lernmark, Åke

“…Aims/hypothesis The aim of this work was to explore molecular amino acids (AAs) and related structures of HLA-DQA1-DQB1 that underlie its contribution to the…”
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216-LB: Genetic Influences on Beta-Cell Function before Type 1 Diabetes Diagnosis by TRIOLO, TAYLOR M., PARIKH, HEMANG M., TOSUR, MUSTAFA, FERRAT, LAURIC A., YOU, LU, GOTTLIEB, PETER, ORAM, RICHARD A., ONENGUT-GUMUSCU, SUNA, KRISCHER, JEFFREY, RICH, STEPHEN S., STECK, ANDREA, REDONDO, MARIA J.

“…Autoimmune loss of beta-cell function (measured by C-peptide) is the hallmark of type 1 diabetes (T1D) targeted by interventions that aim to prevent T1D or its…”
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First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk by Johnson, Suzanne Bennett, Lynch, Kristian F., Roth, Roswith, Lundgren, Markus, Parikh, Hemang M., Akolkar, Beena, Hagopian, William, Krischer, Jeffrey, Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Ziegler, Anette G., Lernmark, Åke

“…Aims/hypothesis Psychological stress has long been considered a possible trigger of type 1 diabetes, although prospective studies examining the link between…”
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243-OR: Integrating Genetic Risk Score and Islet Autoantibody Characteristics in the Predictive Model for Type 1 Diabetes in the TrialNet Study by FERRAT, LAURIC A., STECK, ANDREA, PARIKH, HEMANG M., YOU, LU, ONENGUT-GUMUSCU, SUNA, GOTTLIEB, PETER, RICH, STEPHEN S., KRISCHER, JEFFREY, ORAM, RICHARD A., REDONDO, MARIA J.

“…Background: Type 1 diabetes (T1D) genetic risk score (GRS) and islet autoantibody (AAb) specificity and titers influence T1D risk; however, these factors…”
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Race and Ethnicity, Socioeconomic Factors, and Epigenetic Age Acceleration in Survivors of Childhood Cancer by Chen, Cheng, Plonski, Noel-Marie, Dong, Qian, Song, Nan, Zhang, Xijun, Parikh, Hemang M, Finch, Emily R, Easton, John, Mulder, Heather L, Walker, Emily, Neale, Geoffrey, Pan, Yue, Li, Qian, Zhang, Jinghui, Krull, Kevin, Robison, Leslie L, Armstrong, Gregory T, Yasui, Yutaka, Ness, Kirsten K, Hudson, Melissa M, Wang, Hui, Huang, I-Chan, Wang, Zhaoming

“…Current research in epigenetic age acceleration (EAA) is limited to non-Hispanic White individuals. It is imperative to improve inclusivity by considering…”
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Epigenetic Age in Peripheral Blood Among Children, Adolescent, and Adult Survivors of Childhood Cancer by Plonski, Noel-Marie, Chen, Cheng, Dong, Qian, Qin, Na, Song, Nan, Parikh, Hemang M, Shelton, Kyla, Finch, Emily R, Easton, John, Mulder, Heather, Zhang, Jinghui, Neale, Geoffrey, Walker, Emily, Wang, Hui, Krull, Kevin, Ness, Kirsten K, Hudson, Melissa M, Robison, Leslie L, Li, Qian, Williams, AnnaLynn, Wang, Zhaoming

“…Certain cancer therapies are risk factors for epigenetic age acceleration (EAA) among survivors of childhood cancer, and EAA is associated with chronic health…”
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1462-P: Genetic Risk Score for Type 1 Diabetes across Ethnic Populations via Multitask Learning by Li, Mingqian, Lin, Feng, Zhang, Congjing, Vehik, Kendra, Parikh, Hemang M, Oram, Richard A, Qian, Xiaoning, Huang, Shuai

“…Introduction: Genetic risk scores (GRS) for the prognosis of Stage 3 type 1 diabetes (T1D) are potentially biased due to the predominant race/ethnicity…”
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68-OR: Influence of the Type 1 Diabetes Genetic Risk Score on Response to Immunotherapies for Type 1 Diabetes Prevention by Redondo, Maria J, Bundy, Brian N, Parikh, Hemang M, You, Lu, Triolo, Taylor M, Ferrat, Lauric A, Templeman, Erin, Tosur, Mustafa, Steck, Andrea, Gottlieb, Peter, Onengut-Gumuscu, Suna, Rich, Stephen S, Oram, Richard A, Herold, Kevan C, Krischer, Jeffrey

“…Introduction & Objective: Teplizumab has shown efficacy at delaying the onset of type 1 diabetes (T1D) but markers of response to treatment are needed to…”
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1445-P: Co-occurrence of Islet, Celiac, and Thyroid Autoimmunity in Children Prospectively Followed from Birth in the TEDDY Study by Clasen, Joanna L, Larsson, Helena E, Jonsdottir, Berglind, Haller, Michael J, Agardh, Daniel, Parikh, Hemang M, Lynch, Kristian F, Lernmark, Åke, Rewers, Marian, Mcindoe, Richard, Toppari, Jorma, Ziegler, Anette-Gabriele, Krischer, Jeffrey, Akolkar, Beena, Hagopian, William, Vehik, Kendra

“…Islet autoantibodies (IA) that precede type 1 diabetes, tissue transglutaminase autoantibodies (tTGA) preceding celiac disease, and thyroid peroxidase (TPOA)…”
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1441-P: Low Morning Cortisol in Early Life Associated with Increased Risk of Islet Autoimmunity by Vehik, Kendra, Lynch, Kristian F, Parikh, Hemang M, Lernmark, Åke, Rewers, Marian, Mcindoe, Richard, Toppari, Jorma, Ziegler, Anette-Gabriele, Akolkar, Beena, Hagopian, William, Brusko, Todd M, Krischer, Jeffrey, Roth, Roswith L, Johnson, Suzanne B

“…Introduction & Objective: Stress is implicated as a factor in immune reactivity and autoimmune disorders. Adverse experiences and chronic stress may be…”
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