Search Results - "PARASKEVA, Chris"

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis by Greenhough, Alexander, Bagley, Clare, Heesom, Kate J, Gurevich, David B, Gay, David, Bond, Mark, Collard, Tracey J, Paraskeva, Chris, Martin, Paul, Sansom, Owen J, Malik, Karim, Williams, Ann C

“…Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in…”
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Circulating prostaglandins as biomarkers for colorectal cancer? by Greenhough, Alexander, Paraskeva, Chris, Williams, Ann C.

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Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk by Petherick, Katy J, Williams, Ann C, Lane, Jon D, Ordóñez-Morán, Paloma, Huelsken, Joerg, Collard, Tracey J, Smartt, Helena JM, Batson, Jennifer, Malik, Karim, Paraskeva, Chris, Greenhough, Alexander

“…The Wnt/β‐catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify…”
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LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs by Al-Kharusi, Manal R A, Smartt, Helena J M, Greenhough, Alexander, Collard, Tracey J, Emery, Elizabeth D, Williams, Ann C, Paraskeva, Chris

“…Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E2 (PGE2), promoting many hallmarks of…”
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β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells by Smartt, Helena J M, Greenhough, Alexander, Ordóñez-Morán, Paloma, Talero, Elena, Cherry, Catherine A, Wallam, Catherine A, Parry, Lee, Al Kharusi, Manal, Roberts, Heather R, Mariadason, John M, Clarke, Alan R, Huelsken, Joerg, Williams, Ann C, Paraskeva, Chris

“…Cyclooxygenase-2 (COX-2) overexpression in colorectal cancer increases levels of its pro-tumorigenic product prostaglandin E2 (PGE(2)). The recently identified…”
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LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE 2 : implications for targeting adenoma stem cells with NSAIDs by Al-Kharusi, Manal R.A., Smartt, Helena J.M., Greenhough, Alexander, Collard, Tracey J., Emery, Elizabeth D., Williams, Ann C., Paraskeva, Chris

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The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells by Greenhough, A, Wallam, C A, Hicks, D J, Moorghen, M, Williams, A C, Paraskeva, C

“…Overexpression of cyclooxygenase-2 (COX-2) and elevated levels of its enzymatic product prostaglandin E2 (PGE 2 ) occur in the majority of colorectal cancers…”
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Autolysosomal [beta]-catenin degradation regulates Wnt-autophagy-p62 crosstalk by Petherick, Katy J, Williams, Ann C, Lane, Jon D, Ordóñez-morán, Paloma, Huelsken, Joerg, Collard, Tracey J, Smartt, Helena Jm, Batson, Jennifer, Malik, Karim, Paraskeva, Chris, Greenhough, Alexander

“…The Wnt/[beta]-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we…”
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Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells by H-ZADEH, Akram M, COLLARD, Tracey J, MALIK, Karim, HICKS, Diane J, PARASKEVA, Chris, WILLIAMS, Ann C

“…The insulin-like growth factor binding protein 3 (IGFBP-3) is the major circulating IGF binding protein, its function regulated by proteolytic cleavage. The…”
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Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells by WILLIAMS, A. C, COLLARD, T. J, PERKS, C. M, NEWCOMB, P, MOORGHEN, M, HOLLY, J. M. P, PARASKEVA, C

“…We investigated the expression of insulin-like growth factor binding protein 3 (IGFBP-3) in normal human colonic epithelium and whether IGFBP-3 is involved in…”
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The retinoblastoma protein interacts with Bag‐1 in human colonic adenoma and carcinoma derived cell lines by Arhel, Nathalie J., Packham, Graham, Townsend, Paul A., Collard, Tracey J., H‐Zadeh, Akram M., Sharp, Adam, Cutress, Ramsey I., Malik, Karim, Hague, Angela, Paraskeva, Chris, Williams, Ann C.

“…Although the retinoblastoma susceptibility gene RB1 is inactivated in a wide range of human tumours, overexpression in colonic carcinomas has been linked to…”
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Expression of Concern: The retinoblastoma protein interacts with Bag‐1 in human colonic adenoma and carcinoma derived cell lines by Arhel, Nathalie J., Packham, Graham, Townsend, Paul A., Collard, Tracey J., H‐Zadeh, Akram M., Sharp, Adam, Cutress, Ramsey I., Malik, Karim, Hague, Angela, Paraskeva, Chris, Williams, Ann C.

“…Although the retinoblastoma susceptibility gene RB1 is inactivated in a wide range of human tumours, overexpression in colonic carcinomas has been linked to…”
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