Search Results - "PARAPINI, Silvia"

Antimalarial Activity of Tri- and Tetra-Substituted Anilino Pyrazoles by Lusardi, Matteo, Basilico, Nicoletta, Rotolo, Chiara, Parapini, Silvia, Spallarossa, Andrea

“…Pyrazole core represents a privilege scaffold in medicinal chemistry; a number of pyrazole compounds are endowed with various pharmacological activities in…”
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Characterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion by Paone, Silvio, D’Alessandro, Sarah, Parapini, Silvia, Celani, Francesco, Tirelli, Valentina, Pourshaban, Manoochehr, Olivieri, Anna

“…Malaria is still a devastating disease with 228 million cases globally and 405,000 lethal outcomes in 2018, mainly in children under five years of age. The…”
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Safety of Artemisinin Derivatives in the First Trimester of Pregnancy: A Controversial Story by D'Alessandro, Sarah, Menegola, Elena, Parapini, Silvia, Taramelli, Donatella, Basilico, Nicoletta

“…Artemisinin combination therapy (ACT) is recommended by the World Health Organization (WHO) as first line treatment for uncomplicated malaria both in adults…”
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Oxidative Inactivation of SARS-CoV-2 on Photoactive AgNPs@TiO2 Ceramic Tiles by Djellabi, Ridha, Basilico, Nicoletta, Delbue, Serena, D’Alessandro, Sarah, Parapini, Silvia, Cerrato, Giuseppina, Laurenti, Enzo, Falletta, Ermelinda, Bianchi, Claudia

“…The current SARS-CoV-2 pandemic causes serious public health, social, and economic issues all over the globe. Surface transmission has been claimed as a…”
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Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity by Pozzetti, Luca, Ibba, Roberta, Rossi, Sara, Taglialatela-Scafati, Orazio, Taramelli, Donatella, Basilico, Nicoletta, D'Alessandro, Sarah, Parapini, Silvia, Butini, Stefania, Campiani, Giuseppe, Gemma, Sandra

“…The potential of natural and synthetic chalcones as therapeutic leads against different pathological conditions has been investigated for several years, and…”
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Screening of Mpro Protease (SARS-CoV-2) Covalent Inhibitors from an Anthocyanin-Rich Blueberry Extract Using an HRMS-Based Analytical Platform by Altomare, Alessandra, Baron, Giovanna, Cambiaghi, Giulia, Ferrario, Giulio, Zoanni, Beatrice, Larissa Della Vedova, Fumagalli, Giulio Maria, Sarah D’Alessandro, Parapini, Silvia, Vittorio, Serena, Vistoli, Giulio, Riso, Patrizia, Carini, Marina, Delbue, Serena, Aldini, Giancarlo

“…Background: The viral main protease (Mpro) of SARS-CoV-2 has been recently proposed as a key target to inhibit virus replication in the host. Therefore,…”
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Role of Stereochemistry on the Biological Activity of Nature-Inspired 3-Br-Acivicin Isomers and Derivatives by Galbiati, Andrea, Zana, Aureliano, Borsari, Chiara, Persico, Marco, Bova, Stefania, Tkachuk, Oleh, Corfu, Alexandra Ioana, Tamborini, Lucia, Basilico, Nicoletta, Fattorusso, Caterina, Bruno, Stefano, Parapini, Silvia, Conti, Paola

“…Chiral natural compounds are often biosynthesized in an enantiomerically pure fashion, and stereochemistry plays a pivotal role in biological activity. Herein,…”
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Synthesis, Molecular Docking and Antiplasmodial Activities of New Tetrahydro-β-Carbolines by Jaromin, Anna, Gryzło, Beata, Jamrozik, Marek, Parapini, Silvia, Basilico, Nicoletta, Cegła, Marek, Taramelli, Donatella, Zagórska, Agnieszka

“…Malaria is still one of the most dangerous infectious diseases and the emergence of drug resistant parasites only worsens the situation. A series of new…”
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Antiplasmodial Activity of p -Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections by Casertano, Marcello, Menna, Marialuisa, Fattorusso, Caterina, Basilico, Nicoletta, Parapini, Silvia, Persico, Marco, Imperatore, Concetta

“…Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of malaria…”
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Benzimidazole derivatives endowed with potent antileishmanial activity by Tonelli, Michele, Gabriele, Elena, Piazza, Francesca, Basilico, Nicoletta, Parapini, Silvia, Tasso, Bruno, Loddo, Roberta, Sparatore, Fabio, Sparatore, Anna

“…Two sets of benzimidazole derivatives were synthesised and tested in vitro for activity against promastigotes of Leishmania tropica and L. infantum. Most of…”
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Heat-Treated Lysozyme Hydrochloride: A Study on Its Structural Modifications and Anti-SARS-CoV-2 Activity by Delbue, Serena, Pariani, Elena, Parapini, Silvia, Galli, Cristina, Basilico, Nicoletta, D'Alessandro, Sarah, Pellegrino, Sara, Pini, Elena, Ciceri, Samuele, Ferraboschi, Patrizia, Grisenti, Paride

“…Lysozyme (E.C. 3.2.1.17), an about 14 kDa protein and pI 11, widely spread in nature, is present in humans mainly in milk, saliva, and intestinal mucus as a…”
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In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release by Dolci, Maria, Signorini, Lucia, D'Alessandro, Sarah, Perego, Federica, Parapini, Silvia, Sommariva, Michele, Taramelli, Donatella, Ferrante, Pasquale, Basilico, Nicoletta, Delbue, Serena

“…In the novel pandemic of Coronavirus Disease 2019, high levels of pro-inflammatory cytokines lead to endothelial activation and dysfunction, promoting a…”
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Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone by Imperatore, Concetta, Gimmelli, Roberto, Persico, Marco, Casertano, Marcello, Guidi, Alessandra, Saccoccia, Fulvio, Ruberti, Giovina, Luciano, Paolo, Aiello, Anna, Parapini, Silvia, Avunduk, Sibel, Basilico, Nicoletta, Fattorusso, Caterina, Menna, Marialuisa

“…The chemical analysis of the sponge afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the…”
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Multiplex array analysis of circulating cytokines and chemokines in COVID-19 patients during the first wave of the SARS-CoV-2 pandemic in Milan, Italy by Calvo-Alvarez, Estefanía, D'Alessandro, Sarah, Zanotta, Nunzia, Basilico, Nicoletta, Parapini, Silvia, Signorini, Lucia, Perego, Federica, Maina, Kevin Kamau, Ferrante, Pasquale, Modenese, Annalisa, Pizzocri, Pierluigi, Ronsivalle, Andrea, Delbue, Serena, Comar, Manola

“…The systemic inflammatory syndrome called "cytokine storm" has been described in COVID-19 pathogenesis, contributing to disease severity. The analysis of…”
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Phagocytosis and activation of bone marrow-derived macrophages by Plasmodium falciparum gametocytes by Corbett, Yolanda, Parapini, Silvia, Perego, Federica, Messina, Valeria, Delbue, Serena, Misiano, Paola, Falchi, Mario, Silvestrini, Francesco, Taramelli, Donatella, Basilico, Nicoletta, D'Alessandro, Sarah

“…The innate immune response against various life cycle stages of the malaria parasite plays an important role in protection against the disease and regulation…”
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Efficient One-Pot Synthesis of Novel Caffeic Acid Derivatives as Potential Antimalarials by Sidoryk, Katarzyna, Parapini, Silvia, Basilico, Nicoletta, Zaremba-Czogalla, Magdalena, Kubiszewski, Marek, Cybulski, Marcin, Gubernator, Jerzy, Zagórska, Agnieszka, Jaromin, Anna

“…New protocol for the preparation of the novel caffeic acid derivatives using the Wittig reaction has been applied to follow the principles of green chemistry…”
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Facile Preparation of N -Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities by Wu, Yuet, Parapini, Silvia, Williams, Ian D, Misiano, Paola, Wong, Ho Ning, Taramelli, Donatella, Basilico, Nicoletta, Haynes, Richard K

“…According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar…”
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Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against Leishmania Hsp90 by Bassanini, Ivan, Parapini, Silvia, Ferrandi, Erica E, Gabriele, Elena, Basilico, Nicoletta, Taramelli, Donatella, Sparatore, Anna

“…The natural triterpene celastrol ( ) is here used as lead compound for the design and synthesis of a panel of eleven carboxamides that were tested in vitro for…”
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Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle by Finaurini, Sara, Basilico, Nicoletta, Corbett, Yolanda, D’Alessandro, Sarah, Parapini, Silvia, Olliaro, Piero, Haynes, Richard K, Taramelli, Donatella

“…Abstract Artemisinin derivatives such as dihydroartemisinin (DHA) induce significant depletion of early embryonic erythroblasts in animal models. We have…”
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In Vitro Antiparasitic Activities of Monovalent Ionophore Compounds for Human and Canine Leishmaniases by Calvo Alvarez, Estefanía, D'Alessandro, Sarah, Proverbio, Daniela, Spada, Eva, Perego, Roberta, Taramelli, Donatella, Basilico, Nicoletta, Parapini, Silvia

“…The leishmaniases are vector-borne parasitic diseases affecting humans and animals, with high mortality rates in endemic countries. Infected dogs represent the…”
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