Search Results - "PARAMIO, J. M"

The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas by Pérez-Gómez, E, Andradas, C, Flores, J M, Quintanilla, M, Paramio, J M, Guzmán, M, Sánchez, C

“…G protein-coupled receptors (GPCRs) control crucial physiological processes and their dysfunction contributes to various human diseases, including cancer. The…”
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Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis by da Silva-Diz, V, Solé-Sánchez, S, Valdés-Gutiérrez, A, Urpí, M, Riba-Artés, D, Penin, R M, Pascual, G, González-Suárez, E, Casanovas, O, Viñals, F, Paramio, J M, Batlle, E, Muñoz, P

“…Epidermal keratinocytes and hair follicle (HF) stem cells (SCs) expressing oncogenes are competent at developing squamous cell carcinomas (SCCs) in epidermis…”
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Genomic landscape and immune-related gene expression profiling of epithelial ovarian cancer after neoadjuvant chemotherapy by Lodewijk, I., Bernardini, A., Suárez-Cabrera, C., Bernal, E., Sánchez, R., Garcia, J. L., Rojas, K., Morales, L., Wang, S., Han, X., Dueñas, M., Paramio, J. M., Manso, L.

“…Platinum-based neoadjuvant chemotherapy followed by interval debulking surgery is an accepted treatment for patients with stage III or IV epithelial ovarian…”
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Molecular determinants of Akt-induced keratinocyte transformation by SEGRELLES, C, MORAL, M, BALLESTIN, C, PARAMIO, J. M, FERNANDA LARA, M, RUIZ, S, SANTOS, M, LEIS, H, GARCIA-ESCUDERO, R, MARTINEZ-CRUZ, A. B, MARTINEZ-PALACIO, J, HERNANDEZ, P

“…The PI3K/PTEN/Akt signaling pathway has emerged in recent years as a main player in human cancers, increasing proliferation and decreasing apoptosis of…”
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p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes by Pippa, R, Espinosa, L, Gundem, G, García-Escudero, R, Dominguez, A, Orlando, S, Gallastegui, E, Saiz, C, Besson, A, Pujol, M J, López-Bigas, N, Paramio, J M, Bigas, A, Bachs, O

“…The cyclin-cdk (cyclin-dependent kinase) inhibitor p27 Kip1 (p27) has a crucial negative role on cell cycle progression. In addition to its classical role as a…”
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PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein by PARAMIO, J. M, NAVARRO, M, SEGRELLES, C, GOMEZ-CASERO, E, JORCANO, J. L

“…The tumour suppressor PTEN, also named MMAC1 or TEP1, is associated with a number of malignancies in human populations. This protein has a dual protein…”
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Macrophage polarization as a novel weapon in conditioning tumor microenvironment for bladder cancer: can we turn demons into gods? by Rubio, C., Munera-Maravilla, E., Lodewijk, I., Suarez-Cabrera, C., Karaivanova, V., Ruiz-Palomares, R., Paramio, J. M., Dueñas, M.

“…Macrophages are major components of the immune infiltration in cancer where they can affect tumor behavior. In the bladder, they play important roles during…”
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Exosomes in NSCLC: Analysis of its cargo as a source of biomarkers by Durendez-Saez, E., Calabuig Fariñas, S., Suarez, C., Mosqueda, M., Gallach, S., Escorihuela, E., Moreno, A., Dong, N., Herreros Pomares, A., de la Cueva, E., Martinez-Romero, A., Serna, E., Paramio, J.M., Jantus-Lewintre, E., Camps, C.

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E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis by Costa, C, Santos, M, Martínez-Fernández, M, Dueñas, M, Lorz, C, García-Escudero, R, Paramio, J M

“…The specific ablation of Rb1 gene in epidermis (Rb F/F ;K14cre) promotes proliferation and altered differentiation but does not produce spontaneous tumour…”
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Opposite Functions for E2F1 and E2F4 in Human Epidermal Keratinocyte Differentiation by Paramio, Jesús M., Segrelles, Carmen, Casanova, M. Llanos, Jorcano, José L.

“…Proteins of the retinoblastoma family (pRb, p107, and p130) modulate cell proliferation, a function related to their capacity to control the activity of the…”
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p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia by Saiz-Ladera, C, Lara, M F, Garín, M, Ruiz, S, Santos, M, Lorz, C, García-Escudero, R, Martínez-Fernández, M, Bravo, A, Fernández-Capetillo, O, Segrelles, C, Paramio, J M

“…The retinoblastoma gene product (pRb) controls proliferation and differentiation processes in stratified epithelia. Importantly, and in contrast to other…”
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Changes in proteasome localization during the cell cycle by Palmer, A, Mason, G G, Paramio, J M, Knecht, E, Rivett, A J

“…We have investigated proteasome localization in synchronized cells using polyclonal anti-proteasome antibodies. Proteasomes were localized in the nucleus and…”
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Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation by PARAMIO, J. M, LAIN, S, SEGRELLES, C, LANE, E. B, JORCANO, J. L

“…Terminal differentiation requires cell cycle withdrawal, suggesting the involvement of negative cell cycle controllers in the process. We have analysed the…”
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Role of protein kinases in the in vitro differentiation of human epidermal HaCaT cells by PARAMIO, J. M, JORCANO, J. L

“…Different chemicals that specifically and selectively inhibit or activate protein kinases have been used to define the possible roles of these enzymes in the…”
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Inhibition of Protein Kinase B (PKB) and PKCζ Mediates Keratin K10-Induced Cell Cycle Arrest by Paramio, Jesus M., Segrelles, Carmen, Ruiz, Sergio, Jorcano, José L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis by Ruiz, Sergio, Santos, Mirentxu, Segrelles, Carmen, Leis, Hugo, Jorcano, José Luis, Berns, Anton, Paramio, Jesús M, Vooijs, Marc

“…The retinoblastoma gene product, pRb, plays a crucial role in cell cycle regulation, differentiation and inhibition of oncogenic transformation. pRb and its…”
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Functional roles of Akt signaling in mouse skin tumorigenesis by SEGRELLES, Carmen, RUIZ, Sergio, JORCANO, Jose L, PARAMIO, Jesus M, PEREZ, Paloma, MURGA, Cristina, SANTOS, Mirentxu, BUDUNOVA, Irina V, MARTINEZ, Jesus, LARCHER, Fernando, SLAGA, Thomas J, GUTKIND, J. Silvio

“…The mouse skin carcinogenesis protocol is a unique model for understanding the molecular events leading to oncogenic transformation. Mutations in the Ha-ras…”
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Modulation of Cell Proliferation by Cytokeratins K10 and K16 by Paramio, Jesús M., Casanova, M. Llanos, Segrelles, Carmen, Mittnacht, Sybille, Lane, E. Birgitte, Jorcano, José L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Akt mediates an angiogenic switch in transformed keratinocytes by Segrelles, Carmen, Ruiz, Sergio, Santos, Mirentxu, Martínez-Palacio, Jesús, Lara, M. Fernanda, Paramio, Jesús M.

“…Akt signaling is involved in tumorigenesis via a number of different mechanisms that result in increased proliferation and decreased apoptosis. Previous data…”
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Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130 by Ruiz, Sergio, Segrelles, Carmen, Bravo, Ana, Santos, Mirentxu, Perez, Paloma, Leis, Hugo, Jorcano, Jose L, Paramio, Jesús M

“…The functions of p107 and p130, members of the retinoblastoma family, include the control of cell cycle progression and differentiation in several tissues. Our…”
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