Search Results - "PARAMESWARAN, Reshmi"

A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers by Wong, Derek P., Roy, Nand K., Zhang, Keman, Anukanth, Anusha, Asthana, Abhishek, Shirkey-Son, Nicole J., Dunmire, Samantha, Jones, Bryan J., Lahr, Walker S., Webber, Beau R., Moriarity, Branden S., Caimi, Paolo, Parameswaran, Reshmi

“…B cell-activating factor (BAFF) binds the three receptors BAFF-R, BCMA, and TACI, predominantly expressed on mature B cells. Almost all B cell cancers are…”
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Repression of GSK3 restores NK cell cytotoxicity in AML patients by Parameswaran, Reshmi, Ramakrishnan, Parameswaran, Moreton, Stephen A., Xia, Zhiqiang, Hou, Yongchun, Lee, Dean A., Gupta, Kalpana, deLima, Marcos, Beck, Rose C., Wald, David N.

“…Natural killer cells from acute myeloid leukaemia patients (AML-NK) show a dramatic impairment in cytotoxic activity. The exact reasons for this dysfunction…”
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Inhibition of O-GlcNAcylation Decreases the Cytotoxic Function of Natural Killer Cells by Feinberg, Daniel, Ramakrishnan, Parameswaran, Wong, Derek P, Asthana, Abhishek, Parameswaran, Reshmi

“…Natural killer (NK) cells mediate killing of malignant and virus-infected cells, a property that is explored as a cell therapy approach in the clinic. Various…”
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Wheat Germ Agglutinin as a Potential Therapeutic Agent for Leukemia by Ryva, Bradley, Zhang, Keman, Asthana, Abhishek, Wong, Derek, Vicioso, Yorleny, Parameswaran, Reshmi

“…Dietary lectins are carbohydrate-binding proteins found in food sources. We used a panel of seven dietary lectins to analyze cytotoxicity against hematological…”
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NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells by Vicioso, Yorleny, Wong, Derek P, Roy, Nand K, Das, Nayanika, Zhang, Keman, Ramakrishnan, Parameswaran, Parameswaran, Reshmi

“…Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked…”
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Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy by Hsieh, Yao-Te, Gang, Eun Ji, Geng, Huimin, Park, Eugene, Huantes, Sandra, Chudziak, Doreen, Dauber, Katrin, Schaefer, Paul, Scharman, Carlton, Shimada, Hiroyuki, Shojaee, Seyedmehdi, Klemm, Lars, Parameswaran, Reshmi, Loh, Mignon, Kang, Eun-Suk, Koo, Hong Hoe, Hofmann, Wolf-Karsten, Andrade, Jacob, Crooks, Gay M., Willman, Cheryl L., Müschen, Markus, Papayannopoulou, Thalia, Heisterkamp, Nora, Bönig, Halvard, Kim, Yong-Mi

“…Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4…”
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BAFF receptor antibody for mantle cell lymphoma therapy by Zhang, Keman, Roy, Nand K, Vicioso, Yorleny, Woo, Janghee, Beck, Rose, de Lima, Marcos, Caimi, Paolo, Feinberg, Daniel, Parameswaran, Reshmi

“…Mantle cell lymphoma (MCL) is an aggressive form of B cell non-Hodgkin's lymphoma and remains incurable under current treatment modalities. One of the main…”
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A Functional Receptor for B-Cell-Activating Factor Is Expressed on Human Acute Lymphoblastic Leukemias by PARAMESWARAN, Reshmi, MÜSCHEN, Markus, KIM, Yong-Mi, GROFFEN, John, HEISTERKAMP, Nora

“…B-lineage acute lymphoblastic leukemia (ALL) arises by transformation of a progenitor (pre-B) cell. Cure rates in adults remain low and treatment is…”
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O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia by Parameswaran, Reshmi, Lim, Min, Arutyunyan, Anna, Abdel-Azim, Hisham, Hurtz, Christian, Lau, Kam, Müschen, Markus, Yu, Robert K, von Itzstein, Mark, Heisterkamp, Nora, Groffen, John

“…The development of resistance to chemotherapy is a major cause of relapse in acute lymphoblastic leukemia (ALL). Though several mechanisms associated with drug…”
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The role of Cdk5/p35 kinase activity in natural killer cell cytotoxicity by Wong, Derek P, Parameswaran, Reshmi

“…Abstract Natural killer (NK) cells and T cells are immune cells with cytotoxic function, but while the distinct role of Cyclin-dependent kinase 5 (Cdk5) in the…”
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Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death by Asthana, Abhishek, Ramakrishnan, Parameswaran, Vicioso, Yorleny, Zhang, Keman, Parameswaran, Reshmi

“…Treatment for acute myeloid leukemia (AML) has remained unchanged for past 40 years. Targeting cell metabolism is a promising avenue for future cancer therapy…”
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Activin β A in term placenta and its correlation with placental inflammation in parturients having epidural or systemic meperidine analgesia: a randomized study by Evron, Shmuel, MD, Parameswaran, Reshmi, PhD, Zipori, Dov, PhD, Ezri, Tiberiu, MD, Sadan, Oscar, MD, Koren, Rumelia, MD

“…Abstract Study Objective To investigate the immunohistochemical localization of β A subunit of activin A in human term placenta, as a marker for placental…”
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The Mesenchymal Stroma Negatively Regulates B Cell Lymphopoiesis through the Expression of Activin A by SHOHAM, TSIPI, PARAMESWARAN, RESHMI, SHAV-TAL, YARON, BARDA-SAAD, MIRA, ZIPORI, DOV

“…: The negative control of B cell generation is only partially resolved. We assessed the role of activin A in regulation of B lymphopoiesis in view of its…”
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Ligand Based CAR T-Cell Targeting BAFF Receptors Asa Novel Therapy for B Cell Malignancies by Parameswaran, Reshmi, Wong, Derek, Zhang, Keman, Asthana, Abhishek, de Lima, Marcos, Caimi, Paolo F

“…Background: Autologous T cells engineered to express chimeric antigen receptors (CARs) targeting CD19 have shown rapid and durable responses in B cell…”
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The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control by BARDA-SAAD, Mira, SHAV-TAL, Yaron, ZIPORI, Dov, ROZENSZAJN, Arie Leon, COHEN, Michal, ZAUBERMAN, Ayelet, KARMAZYN, Asaf, PARAMESWARAN, Reshmi, SCHORI, Hadas, ASHUSH, Hagit, BEN-NUN, Avraham

“…The mesenchyme plays a crucial regulatory role in organ formation and maintenance. However, comprehensive molecular characterization of these cells is lacking…”
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A new Natural Killer cell therapy to target relapse Acute Lymphoblastic Leukemia by Vicioso, Yorleny M, Beck, Rose, Gram, Herman, Zhang, Keman, Asthana, Abhishek, Wong, Derek, Letterio, John, Parameswaran, Reshmi

“…Abstract Acute Lymphoblastic Leukemia (ALL) is the most common childhood cancer. Drug resistance and relapse are two major problems in ALL. Pre-B ALL cells…”
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Abstract 2696: PPAR beta/delta is a novel therapeutic target in acute myeloid leukemia by Hu, Sophia, Wald, David, Parameswaran, Reshmi

“…Abstract Acute myeloid leukemia (AML) is characterized by the differentiation arrest and rapid proliferation of abnormal white blood cells. Current…”
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Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice by Ramakrishnan, Parameswaran, Yui, Mary A, Tomalka, Jeffrey A, Majumdar, Devdoot, Parameswaran, Reshmi, Baltimore, David

“…The nuclear factor-κB protein c-Rel plays a critical role in controlling autoimmunity. c-Rel-deficient mice are resistant to streptozotocin-induced diabetes, a…”
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Abstract 3186: A novel combination therapy for treating advanced drug resistant acute lymphoblastic leukemia by Vicioso, Yorleny M., Beck, Rose, Gram, Herman, Asthana, Abhishek, Zhang, keman, Wong, Derek, Letterio, John, Parameswaran, Reshmi

“…Abstract Purpose: Drug resistance and relapse are two major problems in Acute Lymphoblastic Leukemia (ALL) as these patients do not respond to chemotherapy. We…”
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Deficiency of Nuclear Factor-[kappa]B c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice by Ramakrishnan, Parameswaran, Yui, Mary A, Tomalka, Jeffrey A, Majumdar, Devdoot, Parameswaran, Reshmi, Baltimore, David

“…The nuclear factor-...B protein c-Rel plays a critical role in controlling autoimmunity. c-Rel-deficient mice are resistant to streptozotocin-induced diabetes,…”
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