Search Results - "PAPPO, Alberto"

Rhabdomyosarcoma, Ewing Sarcoma, and Other Round Cell Sarcomas by Pappo, Alberto S, Dirksen, Uta

“…Several recent advances have been made in the diagnosis and therapy of malignant small round cell tumors that affect children, particularly in…”
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Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study by Laetsch, Theodore W, DuBois, Steven G, Mascarenhas, Leo, Turpin, Brian, Federman, Noah, Albert, Catherine M, Nagasubramanian, Ramamoorthy, Davis, Jessica L, Rudzinski, Erin, Feraco, Angela M, Tuch, Brian B, Ebata, Kevin T, Reynolds, Mark, Smith, Steven, Cruickshank, Scott, Cox, Michael C, Pappo, Alberto S, Hawkins, Douglas S

“…Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective…”
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Germline Mutations in Predisposition Genes in Pediatric Cancer by Zhang, Jinghui, Walsh, Michael F, Wu, Gang, Edmonson, Michael N, Gruber, Tanja A, Easton, John, Hedges, Dale, Ma, Xiaotu, Zhou, Xin, Yergeau, Donald A, Wilkinson, Mark R, Vadodaria, Bhavin, Chen, Xiang, McGee, Rose B, Hines-Dowell, Stacy, Nuccio, Regina, Quinn, Emily, Shurtleff, Sheila A, Rusch, Michael, Patel, Aman, Becksfort, Jared B, Wang, Shuoguo, Weaver, Meaghann S, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Gajjar, Amar, Ellison, David W, Pappo, Alberto S, Pui, Ching-Hon, Nichols, Kim E, Downing, James R

“…A constitutive mutation in a cancer-susceptibility gene can have implications for clinical treatment and genetic counseling of family members. This study…”
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Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials by Hong, David S, DuBois, Steven G, Kummar, Shivaani, Farago, Anna F, Albert, Catherine M, Rohrberg, Kristoffer S, van Tilburg, Cornelis M, Nagasubramanian, Ramamoorthy, Berlin, Jordan D, Federman, Noah, Mascarenhas, Leo, Geoerger, Birgit, Dowlati, Afshin, Pappo, Alberto S, Bielack, Stefan, Doz, François, McDermott, Ray, Patel, Jyoti D, Schilder, Russell J, Tahara, Makoto, Pfister, Stefan M, Witt, Olaf, Ladanyi, Marc, Rudzinski, Erin R, Nanda, Shivani, Childs, Barrett H, Laetsch, Theodore W, Hyman, David M, Drilon, Alexander

“…The selective TRK inhibitor larotrectinib was approved for paediatric and adult patients with advanced TRK fusion-positive solid tumours based on a primary…”
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A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children's Oncology Group prospective study by Spunt, Sheri L, Million, Lynn, Chi, Yueh-Yun, Anderson, James, Tian, Jing, Hibbitts, Emily, Coffin, Cheryl, McCarville, M Beth, Randall, R Lor, Parham, David M, Black, Jennifer O, Kao, Simon C, Hayes-Jordan, Andrea, Wolden, Suzanne, Laurie, Fran, Speights, Roseanne, Kawashima, Ellen, Skapek, Stephen X, Meyer, William, Pappo, Alberto S, Hawkins, Douglas S

“…Tumour grade, tumour size, resection potential, and extent of disease affect outcome in paediatric non-rhabdomyosarcoma soft-tissue sarcoma (NRSTS), but no…”
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The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas by DuBois, Steven G., Laetsch, Theodore W., Federman, Noah, Turpin, Brian K., Albert, Catherine M., Nagasubramanian, Ramamoorthy, Anderson, Megan E., Davis, Jessica L., Qamoos, Hope E., Reynolds, Mark E., Cruickshank, Scott, Cox, Michael C., Hawkins, Douglas S., Mascarenhas, Leo, Pappo, Alberto S.

“…Background The highly selective oral tropomyosin receptor kinase (TRK) inhibitor larotrectinib has demonstrated significant activity in adult and pediatric TRK…”
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Top advances of the year: Pediatric oncology by Pappo, Alberto S., Karol, Seth E., Bertrand, Kelsey C.

“…Accelerated discovery and collaborative research continue to highlight the remarkable progress that has been made in the diagnosis and treatment of pediatric…”
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Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study by Rodriguez-Galindo, Carlos, Krailo, Mark D, Krasin, Matthew J, Huang, Li, McCarville, M Beth, Hicks, John, Pashankar, Farzana, Pappo, Alberto S

“…The treatment of childhood nasopharyngeal carcinoma has been adapted from adult regimens; pediatric-specific studies are limited. The ARAR0331 study sought to…”
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A Pilot Trial of Humanized Anti-GD2 Monoclonal Antibody (hu14.18K322A) with Chemotherapy and Natural Killer Cells in Children with Recurrent/Refractory Neuroblastoma by Federico, Sara M, McCarville, M Beth, Shulkin, Barry L, Sondel, Paul M, Hank, Jacquelyn A, Hutson, Paul, Meagher, Michael, Shafer, Aaron, Ng, Catherine Y, Leung, Wing, Janssen, William E, Wu, Jianrong, Mao, Shenghua, Brennan, Rachel C, Santana, Victor M, Pappo, Alberto S, Furman, Wayne L

“…Anti-GD2 mAbs, acting via antibody-dependent cell-mediated cytotoxicity, may enhance the effects of chemotherapy. This pilot trial investigated a fixed dose of…”
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Recent advances in understanding and managing pediatric rhabdomyosarcoma [version 1; peer review: awaiting peer review] by Gartrell, Jessica, Pappo, Alberto

“…Rhabdomyosarcoma (RMS) is a high-grade malignant neoplasm, with a morphologic appearance mimicking that of developing skeletal muscle. Over the last 30 years,…”
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Feasibility of indocyanine green‐guided localization of pulmonary nodules in children with solid tumors by Abdelhafeez, Abdelhafeez H., Mothi, Suraj Sarvode, Pio, Luca, Mori, Motomi, Santiago, Teresa C., McCarville, M. Beth, Kaste, Sue C., Pappo, Alberto S., Talbot, Lindsay J., Murphy, Andrew J., Davidoff, Andrew M.

“…Background Clearing all pulmonary metastases is essential for curing pediatric solid tumors. However, intraoperative localization of such pulmonary nodules can…”
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R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study by PAPPO, Alberto S, PATEL, Shreyaskumar R, GANJOO, Kristen N, SCHUETZE, Scott M, JUERGENS, Heribert, LEAHY, Michael G, GEOERGER, Birgit, BENJAMIN, Robert S, HELMAN, Lee J, BAKER, Laurence H, CROWLEY, John, REINKE, Denise K, KUENKELE, Klaus-Peter, CHAWLA, Sant P, TONER, Guy C, MAKI, Robert G, MEYERS, Paul A, CHUGH, Rashmi

“…The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a…”
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A prospective, comprehensive registry that integrates the molecular analysis of pediatric and adolescent melanocytic lesions by Pappo, Alberto S., McPherson, Valerie, Pan, Haitao, Wang, Fang, Wang, Lu, Wright, Teresa, Hussong, Margaret, Hawkins, Dana, Kaste, Sue C., Davidoff, Andrew M., Bahrami, Armita

“…Background Childhood melanocytic tumors represent a diagnostic and therapeutic challenge, and additional research is needed to better define the natural…”
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Optimal dosing of cyclophosphamide in rhabdomyosarcoma: It's complicated by Lucas, John T., Pappo, Alberto S.

“…Cyclophosphamide dosing has previously been implicated as a risk factor for local failure in rhabdomyosarcoma. Casey et al report on findings from ARST0531…”
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Analysis of Prognostic Factors in Patients With Nonmetastatic Rhabdomyosarcoma Treated on Intergroup Rhabdomyosarcoma Studies III and IV: The Children's Oncology Group by MEZA, Jane L, ANDERSON, James, PAPPO, Alberto S, MEYER, William H

“…The outcome for localized rhabdomyosarcoma (RMS) or undifferentiated sarcoma (UDS) is affected by age, histology, primary anatomic site, extent of disease, and…”
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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma by Chen, Xiang, Bahrami, Armita, Pappo, Alberto, Easton, John, Dalton, James, Hedlund, Erin, Ellison, David, Shurtleff, Sheila, Wu, Gang, Wei, Lei, Parker, Matthew, Rusch, Michael, Nagahawatte, Panduka, Wu, Jianrong, Mao, Shenghua, Boggs, Kristy, Mulder, Heather, Yergeau, Donald, Lu, Charles, Ding, Li, Edmonson, Michael, Qu, Chunxu, Wang, Jianmin, Li, Yongjin, Navid, Fariba, Daw, Najat C, Mardis, Elaine R, Wilson, Richard K, Downing, James R, Zhang, Jinghui, Dyer, Michael A

“…Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs). To…”
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Germline genomic findings in children and young adults with melanocytic tumors by Nagel, Margaret B., Perrino, Melissa R., Nuccio, Regina, Blake, Alise K., Harrison, Lynn, Nichols, Kim E., Pappo, Alberto S.

“…In this retrospective study, we examined the prevalence and spectrum of germline variants in selected cancer predisposition genes in 38 children and young…”
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Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic by Boikos, Sosipatros A, Pappo, Alberto S, Killian, J Keith, LaQuaglia, Michael P, Weldon, Chris B, George, Suzanne, Trent, Jonathan C, von Mehren, Margaret, Wright, Jennifer A, Schiffman, Josh D, Raygada, Margarita, Pacak, Karel, Meltzer, Paul S, Miettinen, Markku M, Stratakis, Constantine, Janeway, Katherine A, Helman, Lee J

“…Wild-type (WT) gastrointestinal stromal tumors (GISTs), which lack KIT and PDGFRA gene mutations, are the primary form of GIST in children and occasionally…”
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Treatment of Pediatric Adrenocortical Carcinoma With Surgery, Retroperitoneal Lymph Node Dissection, and Chemotherapy: The Children's Oncology Group ARAR0332 Protocol by Rodriguez-Galindo, Carlos, Krailo, Mark D, Pinto, Emilia M, Pashankar, Farzana, Weldon, Christopher B, Huang, Li, Caran, Eliana M, Hicks, John, McCarville, M Beth, Malkin, David, Wasserman, Jonathan D, de Oliveira Filho, Antonio G, LaQuaglia, Michael P, Ward, Deborah A, Zambetti, Gerard, Mastellaro, Maria J, Pappo, Alberto S, Ribeiro, Raul C

“…Adrenocortical carcinoma (ACC) is a rare aggressive pediatric malignancy with distinct biology. Its treatment follows the principles developed for adults;…”
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Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic by Weldon, Christopher B, Madenci, Arin L, Boikos, Sosipatros A, Janeway, Katherine A, George, Suzanne, von Mehren, Margaret, Pappo, Alberto S, Schiffman, Joshua D, Wright, Jennifer, Trent, Jonathan C, Pacak, Karel, Stratakis, Constantine A, Helman, Lee J, La Quaglia, Michael P

“…Purpose Wild-type gastrointestinal stromal tumors (WT-GISTs) that lack KIT or PDGFRA mutations represent a unique subtype of GIST that predominantly affects…”
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