Search Results - "PAPI, Chiara"

Treatment of Human Glioblastoma U251 Cells with Sulforaphane and a Peptide Nucleic Acid (PNA) Targeting miR-15b-5p: Synergistic Effects on Induction of Apoptosis by Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Gambari, Laura, Rozzi, Andrea, Manicardi, Alex, Corradini, Roberto, Gambari, Roberto, Finotti, Alessia

“…Glioblastoma multiforme (GBM) is a lethal malignant tumor accounting for 42% of the tumors of the central nervous system, the median survival being 15 months…”
Get full text

SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation by Bezzerri, Valentino, Gentili, Valentina, Api, Martina, Finotti, Alessia, Papi, Chiara, Tamanini, Anna, Boni, Christian, Baldisseri, Elena, Olioso, Debora, Duca, Martina, Tedesco, Erika, Leo, Sara, Borgatti, Monica, Volpi, Sonia, Pinton, Paolo, Cabrini, Giulio, Gambari, Roberto, Blasi, Francesco, Lippi, Giuseppe, Rimessi, Alessandro, Rizzo, Roberta, Cipolli, Marco

“…As an inherited disorder characterized by severe pulmonary disease, cystic fibrosis could be considered a comorbidity for coronavirus disease 2019. Instead,…”
Get full text

Combined Treatment of Bronchial Epithelial Calu-3 Cells with Peptide Nucleic Acids Targeting miR-145-5p and miR-101-3p: Synergistic Enhancement of the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene by Papi, Chiara, Gasparello, Jessica, Zurlo, Matteo, Manicardi, Alex, Corradini, Roberto, Cabrini, Giulio, Gambari, Roberto, Finotti, Alessia

“…The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encodes for a chloride channel defective in Cystic Fibrosis (CF). Accordingly, upregulation…”
Get full text

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike sequences by Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Cosenza, Lucia Carmela, Breveglieri, Giulia, Zuccato, Cristina, Gambari, Roberto, Finotti, Alessia

“…The pandemic caused by the SARS-CoV-2 virus (COVID-19) is still a major health issue. The COVID-19 pandemic has forced the university teaching to consider in…”
Get full text

Demonstrating specificity of bioactive peptide nucleic acids (PNAs) targeting microRNAs for practical laboratory classes of applied biochemistry and pharmacology by Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Corradini, Roberto, Gambari, Roberto, Finotti, Alessia

“…Practical laboratory classes teaching molecular pharmacology approaches employed in the development of therapeutic strategies are of great interest for…”
Get full text

Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota by Secchiero, Paola, Rimondi, Erika, Marcuzzi, Annalisa, Longo, Giovanna, Papi, Chiara, Manfredini, Marta, Fields, Matteo, Caruso, Lorenzo, Di Caprio, Roberta, Balato, Anna

“…In recent years, the incidence of metabolic syndrome (MS) has increased due to lifestyle-related factors in developed countries. MS represents a group of…”
Get full text

A Peptide Nucleic Acid (PNA) Masking the miR-145-5p Binding Site of the 3′UTR of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mRNA Enhances CFTR Expression in Calu-3 Cells by Sultan, Shaiq, Rozzi, Andrea, Gasparello, Jessica, Manicardi, Alex, Corradini, Roberto, Papi, Chiara, Finotti, Alessia, Lampronti, Ilaria, Reali, Eva, Cabrini, Giulio, Gambari, Roberto, Borgatti, Monica

“…Peptide nucleic acids (PNAs) have been demonstrated to be very useful tools for gene regulation at different levels and with different mechanisms of action. In…”
Get full text

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin) by Zuccato, Cristina, Cosenza, Lucia Carmela, Zurlo, Matteo, Gasparello, Jessica, Papi, Chiara, D’Aversa, Elisabetta, Breveglieri, Giulia, Lampronti, Ilaria, Finotti, Alessia, Borgatti, Monica, Scapoli, Chiara, Stievano, Alice, Fortini, Monica, Ramazzotti, Eric, Marchetti, Nicola, Prosdocimi, Marco, Gamberini, Maria Rita, Gambari, Roberto

“…Introduction: β-thalassemia is caused by autosomal mutations in the β-globin gene, which induce the absence or low-level synthesis of β-globin in erythroid…”
Get full text

Cationic Calix[4]arene Vectors to Efficiently Deliver AntimiRNA Peptide Nucleic Acids (PNAs) and miRNA Mimics by Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Volpi, Stefano, Gambari, Roberto, Corradini, Roberto, Casnati, Alessandro, Sansone, Francesco, Finotti, Alessia

“…One of the most appealing approaches for regulating gene expression, named the “microRNA therapeutic” method, is based on the regulation of the activity of…”
Get full text

Efficient Delivery of MicroRNA and AntimiRNA Molecules Using an Argininocalix[4]arene Macrocycle by Gasparello, Jessica, Lomazzi, Michela, Papi, Chiara, D’Aversa, Elisabetta, Sansone, Francesco, Casnati, Alessandro, Donofrio, Gaetano, Gambari, Roberto, Finotti, Alessia

“…MicroRNAs (miRNAs) are short non-coding RNA molecules acting as gene regulators by repressing translation or by inducing degradation of the target RNA…”
Get full text

The Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) Is under Post-Transcriptional Control of microRNAs: Analysis of the Effects of agomiRNAs Mimicking miR-145-5p, miR-101-3p, and miR-335-5p by Papi, Chiara, Gasparello, Jessica, Zurlo, Matteo, Cosenza, Lucia Carmela, Gambari, Roberto, Finotti, Alessia

“…(1) Background: MicroRNAs are involved in the expression of the gene encoding the chloride channel CFTR (Cystic Fibrosis Transmembrane Conductance Regulator);…”
Get full text

Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein by Gasparello, Jessica, D'Aversa, Elisabetta, Papi, Chiara, Gambari, Laura, Grigolo, Brunella, Borgatti, Monica, Finotti, Alessia, Gambari, Roberto

“…•Exposure of bronchial epithelial IB3-1 cells to the SARS-CoV-2 spike protein induces increased release of proteins component of the COVID-19 “cytokine…”
Get full text

Salicylaldoxime Moiety as a Phenolic “A-Ring” Substitute in Estrogen Receptor Ligands by Minutolo, Filippo, Bertini, Simone, Papi, Chiara, Carlson, Kathryn E, Katzenellenbogen, John A, Macchia, Marco

“…The phenolic “A-ring” of natural and synthetic estrogen receptor (ER) ligands was effectively replaced by a planar six-member ring formed through an…”
Get full text

The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-fetal globin genes in human erythroleukemia K562 cells by Zurlo, Matteo, Gasparello, Jessica, Verona, Marco, Papi, Chiara, Cosenza, Lucia Carmela, Finotti, Alessia, Marzaro, Giovanni, Gambari, Roberto

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causative of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The SARS-CoV-2 Spike…”
Get full text

A Magnetic Resonance Imaging‐Chemical Exchange Saturation Transfer (MRI‐CEST) Method for the Detection of Water Cycling across Cellular Membranes by Di Gregorio, Enza, Papi, Chiara, Conti, Laura, Di Lorenzo, Antonino, Cavallari, Eleonora, Salvatore, Marco, Cavaliere, Carlo, Ferrauto, Giuseppe, Aime, Silvio

“…Water cycling across the membrane transporters is considered a hallmark of cellular metabolism and it could be of high diagnostic relevance in the…”
Get full text

Effects of Sulforaphane on SARS‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 ‘cytokine storm’ by Gasparello, Jessica, Marzaro, Giovanni, Papi, Chiara, Gentili, Valentina, Rizzo, Roberta, Zurlo, Matteo, Scapoli, Chiara, Finotti, Alessia, Gambari, Roberto

“…Since its spread at the beginning of 2020, the coronavirus disease 2019 (COVID-19) pandemic represents one of the major health problems. Despite the approval,…”
Get full text

Effects of Sulforaphane on SARS-CoV-2 infection and NF-[kappa]B dependent expression of genes involved in the COVID-19 'cytokine storm' by Gasparello, Jessica, Marzaro, Giovanni, Papi, Chiara, Gentili, Valentina, Rizzo, Roberta, Zurlo, Matteo, Scapoli, Chiara, Finotti, Alessia, Gambari, Roberto

“…Since its spread at the beginning of 2020, the coronavirus disease 2019 (COVID-19) pandemic represents one of the major health problems. Despite the approval,…”
Get full text

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells by Zurlo, Matteo, Nicoli, Francesco, Proietto, Davide, Dallan, Beatrice, Zuccato, Cristina, Cosenza, Lucia Carmela, Gasparello, Jessica, Papi, Chiara, d'Aversa, Elisabetta, Borgatti, Monica, Scapoli, Chiara, Finotti, Alessia, Gambari, Roberto

“…Inhibitors of the mammalian target of rapamycin (mTOR) have been proposed to improve vaccine responses, especially in the elderly. Accordingly, testing mTOR…”
Get full text

Demonstrating specificity of bioactive peptide nucleic acids by Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Corradini, Roberto, Gambari, Roberto, Finotti, Alessia

“…Practical laboratory classes teaching molecular pharmacology approaches employed in the development of therapeutic strategies are of great interest for…”
Get full text

MicroRNAs miR-584-5p and miR-425-3p Are Up-Regulated in Plasma of Colorectal Cancer (CRC) Patients: Targeting with Inhibitor Peptide Nucleic Acids Is Associated with Induction of Apoptosis in Colon Cancer Cell Lines by Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Gambari, Laura, Manicardi, Alex, Rozzi, Andrea, Ferrarini, Matteo, Corradini, Roberto, Gambari, Roberto, Finotti, Alessia

“…Liquid biopsy has dramatically changed cancer management in the last decade; however, despite the huge number of miRNA signatures available for diagnostic or…”
Get full text