Search Results - "PAPAGIANNAKOPOULOS, Thales"

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment by Kerk, Samuel A., Papagiannakopoulos, Thales, Shah, Yatrik M., Lyssiotis, Costas A.

“…Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour survival, growth and immune evasion in colorectal carcinoma,…”
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NRF2: KEAPing Tumors Protected by Pillai, Ray, Hayashi, Makiko, Zavitsanou, Anastasia-Maria, Papagiannakopoulos, Thales

“…The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway plays a physiologic protective role against…”
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Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1 by Lignitto, Luca, LeBoeuf, Sarah E., Homer, Harrison, Jiang, Shaowen, Askenazi, Manor, Karakousi, Triantafyllia R., Pass, Harvey I., Bhutkar, Arjun J., Tsirigos, Aristotelis, Ueberheide, Beatrix, Sayin, Volkan I., Papagiannakopoulos, Thales, Pagano, Michele

“…Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2, resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which…”
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MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells by PAPAGIANNAKOPOULOS, Thales, SHAPIRO, Alice, KOSIK, Kenneth S

“…MicroRNA dysregulation is observed in different types of cancer. MiR-21 up-regulation has been reported for the majority of cancers profiled to date; however,…”
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Metabolic features of cancer cells in NRF2 addiction status by Okazaki, Keito, Papagiannakopoulos, Thales, Motohashi, Hozumi

“…The KEAP1-NRF2 system is a sulfur-employing defense mechanism against oxidative and electrophilic stress. NRF2 is a potent transcription activator for genes…”
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Circadian Rhythm Disruption Promotes Lung Tumorigenesis by Papagiannakopoulos, Thales, Bauer, Matthew R., Davidson, Shawn M., Heimann, Megan, Subbaraj, Lakshmipriya, Bhutkar, Arjun, Bartlebaugh, Jordan, Vander Heiden, Matthew G., Jacks, Tyler

“…Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and…”
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CRISPR-mediated direct mutation of cancer genes in the mouse liver by Xue, Wen, Chen, Sidi, Yin, Hao, Tammela, Tuomas, Papagiannakopoulos, Thales, Joshi, Nikhil S., Cai, Wenxin, Yang, Gillian, Bronson, Roderick, Crowley, Denise G., Zhang, Feng, Anderson, Daniel G., Sharp, Phillip A., Jacks, Tyler

“…CRISPR plasmids targeting Pten and p53 , alone and in combination, are delivered by hydrodynamic injection to the liver; the CRISPR-mediated mutations…”
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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer by Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales

“…During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis,…”
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Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs by Minton, Denise R., Nam, Minwoo, McLaughlin, Daniel J., Shin, Jong, Bayraktar, Erol C., Alvarez, Samantha W., Sviderskiy, Vladislav O., Papagiannakopoulos, Thales, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard

“…Upon glucose restriction, eukaryotic cells upregulate oxidative metabolism to maintain homeostasis. Using genetic screens, we find that the mitochondrial…”
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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids by LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-Kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales

“…Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire novel nutrient dependencies to support oncogenic growth. A major genetic…”
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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer by Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.

“…Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype…”
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MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells by Xu, Na, Papagiannakopoulos, Thales, Pan, Guangjin, Thomson, James A., Kosik, Kenneth S.

“…MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an important role in many developmental processes. We report here that…”
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Improving oligo-conjugated antibody signal in multimodal single-cell analysis by Buus, Terkild B, Herrera, Alberto, Ivanova, Ellie, Mimitou, Eleni, Cheng, Anthony, Herati, Ramin S, Papagiannakopoulos, Thales, Smibert, Peter, Odum, Niels, Koralov, Sergei B

“…Simultaneous measurement of surface proteins and gene expression within single cells using oligo-conjugated antibodies offers high-resolution snapshots of…”
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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion by Marzio, Antonio, Kurz, Emma, Sahni, Jennifer M., Di Feo, Giuseppe, Puccini, Joseph, Jiang, Shaowen, Hirsch, Carolina Alcantara, Arbini, Arnaldo A., Wu, Warren L., Pass, Harvey I., Bar-Sagi, Dafna, Papagiannakopoulos, Thales, Pagano, Michele

“…Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to immunotherapy. Here, we show that KEAP1 targets EMSY for…”
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Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy by Wu, Lin, Hollinshead, Kate E.R., Hao, Yuhan, Au, Christy, Kroehling, Lina, Ng, Charles, Lin, Woan-Yu, Li, Dayi, Silva, Hernandez Moura, Shin, Jong, Lafaille, Juan J., Possemato, Richard, Pacold, Michael E., Papagiannakopoulos, Thales, Kimmelman, Alec C., Satija, Rahul, Littman, Dan R.

“…Targeting glycolysis has been considered therapeutically intractable owing to its essential housekeeping role. However, the context-dependent requirement for…”
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In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras -Mutant Lung Adenocarcinoma by Li, Fei, Huang, Qingyuan, Luster, Troy A, Hu, Hai, Zhang, Hua, Ng, Wai-Lung, Khodadadi-Jamayran, Alireza, Wang, Wei, Chen, Ting, Deng, Jiehui, Ranieri, Michela, Fang, Zhaoyuan, Pyon, Val, Dowling, Catríona M, Bagdatlioglu, Ece, Almonte, Christina, Labbe, Kristen, Silver, Heather, Rabin, Alexandra R, Jani, Kandarp, Tsirigos, Aristotelis, Papagiannakopoulos, Thales, Hammerman, Peter S, Velcheti, Vamsidhar, Freeman, Gordon J, Qi, Jun, Miller, George, Wong, Kwok-Kin

“…Despite substantial progress in lung cancer immunotherapy, the overall response rate in patients with -mutant lung adenocarcinoma (LUAD) remains low. Combining…”
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Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing by McFadden, David G., Papagiannakopoulos, Thales, Taylor-Weiner, Amaro, Stewart, Chip, Carter, Scott L., Cibulskis, Kristian, Bhutkar, Arjun, McKenna, Aaron, Dooley, Alison, Vernon, Amanda, Sougnez, Carrie, Malstrom, Scott, Heimann, Megan, Park, Jennifer, Chen, Frances, Farago, Anna F., Dayton, Talya, Shefler, Erica, Gabriel, Stacey, Getz, Gad, Jacks, Tyler

“…Small cell lung carcinoma (SCLC) is a highly lethal, smoking-associated cancer with few known targetable genetic alterations. Using genome sequencing, we…”
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ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer by Purohit, Vinee, Wang, Lidong, Yang, Huibin, Li, Jiufeng, Ney, Gina M, Gumkowski, Erica R, Vaidya, Akash J, Wang, Annie, Bhardwaj, Amit, Zhao, Ende, Dolgalev, Igor, Zamperone, Andrea, Abel, Ethan V, Magliano, Marina Pasca Di, Crawford, Howard C, Diolaiti, Daniel, Papagiannakopoulos, Thales Y, Lyssiotis, Costas A, Simeone, Diane M

“…Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little is…”
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Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma by Snuderl, Matija, Kannan, Kasthuri, Pfaff, Elke, Wang, Shiyang, Stafford, James M., Serrano, Jonathan, Heguy, Adriana, Ray, Karina, Faustin, Arline, Aminova, Olga, Dolgalev, Igor, Stapleton, Stacie L., Zagzag, David, Chiriboga, Luis, Gardner, Sharon L., Wisoff, Jeffrey H., Golfinos, John G., Capper, David, Hovestadt, Volker, Rosenblum, Marc K., Placantonakis, Dimitris G., LeBoeuf, Sarah E., Papagiannakopoulos, Thales Y., Chavez, Lukas, Ahsan, Sama, Eberhart, Charles G., Pfister, Stefan M., Jones, David T. W., Karajannis, Matthias A.

“…Pineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients…”
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Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events by Ashouri, Arghavan, Sayin, Volkan I., Van den Eynden, Jimmy, Singh, Simranjit X., Papagiannakopoulos, Thales, Larsson, Erik

“…Thousands of long non-coding RNAs (lncRNAs) lie interspersed with coding genes across the genome, and a small subset has been implicated as downstream…”
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