Search Results - "PAPA, R."

The Role of Endoplasmic Reticulum Stress in Human Pathology by Oakes, Scott A, Papa, Feroz R

“…Numerous genetic and environmental insults impede the ability of cells to properly fold and posttranslationally modify secretory and transmembrane proteins in…”
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Signaling cell death from the endoplasmic reticulum stress response by Shore, Gordon C, Papa, Feroz R, Oakes, Scott A

“…Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), a signaling pathway with both…”
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Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes by Ghosh, Rajarshi, Colon-Negron, Kevin, Papa, Feroz R.

“…Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) — a condition referred…”
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Intracellular signaling by the unfolded protein response by Bernales, Sebastián, Papa, Feroz R, Walter, Peter

“…The unfolded protein response (UPR) is an intracellular signaling pathway that is activated by the accumulation of unfolded proteins in the endoplasmic…”
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The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry by Lachmann, H J, Papa, R, Gerhold, K, Obici, L, Touitou, I, Cantarini, L, Frenkel, J, Anton, J, Kone-Paut, I, Cattalini, M, Bader-Meunier, B, Insalaco, A, Hentgen, V, Merino, R, Modesto, C, Toplak, N, Berendes, R, Ozen, S, Cimaz, R, Jansson, A, Brogan, P A, Hawkins, P N, Ruperto, N, Martini, A, Woo, P, Gattorno, M

“…To evaluate the genetic findings, demographic features and clinical presentation of tumour necrosis factor receptor-associated autoinflammatory syndrome…”
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IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress by Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.

“…When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded…”
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Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress by Ghosh, Rajarshi, Wang, Likun, Wang, Eric S., Perera, B. Gayani K., Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F., Gliedt, Micah J., Alavi, Marcel V., Hari, Sanjay B., Mitra, Arinjay K., Bhhatarai, Barun, Schürer, Stephan C., Snapp, Erik L., Gould, Douglas B., German, Michael S., Backes, Bradley J., Maly, Dustin J., Oakes, Scott A., Papa, Feroz R.

“…Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER…”
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Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung by Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C, Brumwell, Alexis, Chapman, Harold A, Backes, Bradley J, Perara, Gayani, Maly, Dustin J, Sheppard, Dean, Papa, Feroz R

“…Endoplasmic reticulum stress (ER stress) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease of progressive fibrosis and…”
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Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress by Igbaria, Aeid, Merksamer, Philip I., Trusina, Ala, Tilahun, Firehiwot, Johnson, Jeffrey R., Brandman, Onn, Krogan, Nevan J., Weissman, Jonathan S., Papa, Feroz R.

“…Diverse perturbations to endoplasmic reticulum (ER) functions compromise the proper folding and structural maturation of secretory proteins. To study secretory…”
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On the Mechanism of Sensing Unfolded Protein in the Endoplasmic Reticulum by Joel J. Credle, Finer-Moore, Janet S., Papa, Feroz R., Stroud, Robert M., Walter, Peter

“…Unfolded proteins in the endoplasmic reticulum (ER) activate the ER transmembrane sensor Ire1 to trigger the unfolded protein response (UPR), a homeostatic…”
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Druggable sensors of the unfolded protein response by Maly, Dustin J, Papa, Feroz R

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The Unfolded Protein Response and Cell Fate Control by Hetz, Claudio, Papa, Feroz R.

“…The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and match the protein-folding…”
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Asymmetry of gene flow and differential geographical structure of molecular diversity in wild and domesticated common bean (Phaseolus vulgaris L.) from Mesoamerica by PAPA, R, GEPTS, P

“…Using amplified fragment length polymorphisms (AFLPs), we analyzed the genetic structure of wild and domesticated common bean (Phaseolus vulgaris L.) from…”
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Advantage of wavelet technique to highlight the observed geomagnetic perturbations linked to the Chilean tsunami (2010) by Klausner, V., Mendes, Odim, Domingues, Margarete O., Papa, Andres R. R., Tyler, Robert H., Frick, Peter, Kherani, Esfhan A.

“…The vertical component (Z) of the geomagnetic field observed by ground‐based observatories of the International Real‐Time Magnetic Observatory Network has been…”
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Brillouin optical time-domain analysis for geotechnical monitoring by L. Zeni, L. Picarelli, B. Avolio, A. Coscetta, R. Papa, G. Zeni, C. Di Maio, R. Vassallo, A. Minardo

“…In this paper, we show some recent experimental applications of Brillouin optical time-domain analysis (BOTDA) based sensors for geotechnical monitoring. In…”
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Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress by Upton, John-Paul, Austgen, Kathryn, Nishino, Mari, Coakley, Kristen M., Hagen, Andrew, Han, Dan, Papa, Feroz R., Oakes, Scott A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib by Yamashita, Yusuke, Morita, Shuhei, Hosoi, Hiroki, Kobata, Hiroshi, Kishimoto, Shohei, Ishibashi, Tatsuya, Mishima, Hiroyuki, Kinoshita, Akira, Backes, Bradley J, Yoshiura, Koh-Ichiro, Papa, Feroz R, Sonoki, Takashi, Tamura, Shinobu

“…Inositol-requiring enzyme 1α (IRE1α), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein…”
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Demographic factors shaped diversity in the two gene pools of wild common bean Phaseolus vulgaris L by Mamidi, S, Rossi, M, Moghaddam, S M, Annam, D, Lee, R, Papa, R, McClean, P E

“…Wild common bean (Phaseolus vulgaris L.) is distributed throughout the Americas from Mexico to northern Argentina. Within this range, the species is divided…”
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Beans in Europe: origin and structure of the European landraces of Phaseolus vulgaris L by Angioi, S. A, Rau, D, Attene, G, Nanni, L, Bellucci, E, Logozzo, G, Negri, V, Spagnoletti Zeuli, P. L, Papa, R

“…This study focuses on the expansion of Phaseolus vulgaris in Europe. The pathways of distribution of beans into and across Europe were very complex, with…”
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IRE1-Dependent Activation of AMPK in Response to Nitric Oxide by Meares, Gordon P., Hughes, Katherine J., Naatz, Aaron, Papa, Feroz R., Urano, Fumihiko, Hansen, Polly A., Benveniste, Etty N., Corbett, John A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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