Search Results - "PAOLINO, Kristopher"

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial by Modjarrad, Kayvon, Roberts, Christine C, Mills, Kristin T, Castellano, Amy R, Paolino, Kristopher, Muthumani, Kar, Reuschel, Emma L, Robb, Merlin L, Racine, Trina, Oh, Myoung-don, Lamarre, Claude, Zaidi, Faraz I, Boyer, Jean, Kudchodkar, Sagar B, Jeong, Moonsup, Darden, Janice M, Park, Young K, Scott, Paul T, Remigio, Celine, Parikh, Ajay P, Wise, Megan C, Patel, Ami, Duperret, Elizabeth K, Kim, Kevin Y, Choi, Hyeree, White, Scott, Bagarazzi, Mark, May, Jeanine M, Kane, Deborah, Lee, Hyojin, Kobinger, Gary, Michael, Nelson L, Weiner, David B, Thomas, Stephen J, Maslow, Joel N

“…Middle East respiratory syndrome (MERS) coronavirus causes a highly fatal lower-respiratory tract infection. There are as yet no licensed MERS vaccines or…”
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Evaluation of fidaxomicin use in patients with a macrolide allergy/intolerance by Kufel, Wesley D, Hitchcock, Allison M, Delbalso, Alexis N, Paolino, Kristopher M

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Health care response to CCHF in US soldier and nosocomial transmission to health care providers, Germany, 2009 by Conger, Nicholas G, Paolino, Kristopher M, Osborn, Erik C, Rusnak, Janice M, Günther, Stephan, Pool, Jane, Rollin, Pierre E, Allan, Patrick F, Schmidt-Chanasit, Jonas, Rieger, Toni, Kortepeter, Mark G

“…In 2009, a lethal case of Crimean-Congo hemorrhagic fever (CCHF), acquired by a US soldier in Afghanistan, was treated at a medical center in Germany and…”
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Daptomycin Plus Oxacillin for Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia by Kufel, Wesley D., Zagoria, Zoey, Blaine, Bruce E., Steele, Jeffrey M., Mahapatra, Rahul, Paolino, Kristopher M., Thomas, Stephen J.

“…Background: The preferred antibiotic salvage regimen for persistent methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB) is unclear. Ertapenem with…”
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Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine by Farooq, Fouzia, Beck, Kevin, Paolino, Kristopher M., Phillips, Revell, Waters, Norman C., Regules, Jason A., Bergmann-Leitner, Elke S.

“…The most recent Zaire Ebolavirus (ZEBOV) outbreak was the largest and most widespread in recorded history, emphasizing the need for an effective vaccine. Here,…”
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Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study by Regules, Jason A., Cicatelli, Susan B., Bennett, Jason W., Paolino, Kristopher M., Twomey, Patrick S., Moon, James E., Kathcart, April K., Hauns, Kevin D., Komisar, Jack L., Qabar, Aziz N., Davidson, Silas A., Dutta, Sheetij, Griffith, Matthew E., Magee, Charles D., Wojnarski, Mariusz, Livezey, Jeffrey R., Kress, Adrian T., Waterman, Paige E., Jongert, Erik, Wille-Reece, Ulrike, Volkmuth, Wayne, Emerling, Daniel, Robinson, William H., Lievens, Marc, Morelle, Danielle, Lee, Cynthia K., Yassin-Rajkumar, Bebi, Weltzin, Richard, Cohen, Joe, Paris, Robert M., Waters, Norman C., Birkett, Ashley J., Kaslow, David C., Ballou, W. Ripley, Ockenhouse, Christian F., Vekemans, Johan

“…Background. Three full doses of RTS,S/AS01 malaria vaccine provides partial protection against controlled human malaria parasite infection (CHMI) and natural…”
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In vivo pharmacokinetic analysis of meropenem/vaborbactam during continuous venovenous haemodialysis by Kufel, Wesley D, Eranki, Ambika P, Paolino, Kristopher M, Call, Andrea, Miller, Christopher D, Mogle, Bryan T

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Vancomycin plus ceftaroline for persistent methicillin‐resistant Staphylococcus aureus bacteremia by Kufel, Wesley D., Parsels, Katie A., Blaine, Bruce E., Steele, Jeffrey M., Mahapatra, Rahul, Paolino, Kristopher M., Thomas, Stephen J.

“…Study Objective The preferred antibiotic salvage regimen for persistent methicillin‐resistant Staphylococcus aureus bacteremia (MRSAB) is unclear. We sought to…”
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A five-year quasi-experimental study to evaluate the impact of empiric antibiotic order sets on antibiotic use metrics among hospitalized adult patients by Kufel, Wesley D., Steele, Jeffrey M., Mahapatra, Rahul, Brodey, Mitchell V., Wang, Dongliang, Paolino, Kristopher M., Suits, Paul, Empey, Derek W., Thomas, Stephen J.

“…Evaluation of adult antibiotic order sets (AOSs) on antibiotic stewardship metrics has been limited. The primary outcome was to evaluate the standardized…”
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Phase 1 Randomized Study of a Tetravalent Dengue Purified Inactivated Vaccine in Healthy Adults in the United States by Schmidt, Alexander C, Lin, Leyi, Martinez, Luis J, Ruck, Richard C, Eckels, Kenneth H, Collard, Alix, De La Barrera, Rafael, Paolino, Kristopher M, Toussaint, Jean-François, Lepine, Edith, Innis, Bruce L, Jarman, Richard G, Thomas, Stephen J

“…AbstractThe safety and immunogenicity of four formulations of an investigational tetravalent dengue purified inactivated vaccine (DPIV), formulated at 1 or 4…”
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Impact of a pharmacist-facilitated, evidence-based bundle initiative on Staphylococcus aureus bacteremia management by Kufel, Wesley D., Mastro, Keri A., Steele, Jeffrey M., Wang, Dongliang, Riddell, Scott W., Paolino, Kristopher M., Thomas, Stephen J.

“…•Staphylococcus aureus bacteremia (SAB) is a common infectious disease (ID).•Pharmacists are well-positioned to assist ID consultation (IDC) with SAB…”
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A Phase 1, Open-Label Assessment of a Dengue Virus-1 Live Virus Human Challenge Strain by Endy, Timothy P, Wang, Dongliang, Polhemus, Mark E, Jarman, Richard G, Jasper, Louis E, Gromowski, Greg, Lin, Leyi, De La Barra, Rafael A, Friberg, Heather, Currier, Jeffrey R, Abbott, Mark, Ware, Lisa, Klick, Michelle, Paolino, Kristopher M, Blair, Donald C, Eckels, Kenneth, Rutvisuttinunt, Wiriya, Thomas, Stephen J

“…Abstract Background Dengue human infection models (DHIM) have been used as a safe means to test the viability of prophylaxis and therapeutics. Methods A phase…”
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Immunogenicity of a Live-Attenuated Dengue Vaccine Using a Heterologous Prime-Boost Strategy in a Phase 1 Randomized Clinical Trial by Lin, Leyi, Koren, Michael A, Paolino, Kristopher M, Eckels, Kenneth H, De La Barrera, Rafael, Friberg, Heather, Currier, Jeffrey R, Gromowski, Gregory D, Aronson, Naomi E, Keiser, Paul B, Sklar, Marvin J, Sondergaard, Erica L, Jasper, Louis E, Endy, Timothy P, Jarman, Richard G, Thomas, Stephen J

“…Abstract Background Dengue is a global health problem and the development of a tetravalent dengue vaccine with durable protection is a high priority. A…”
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Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults by Ockenhouse, Christian F, Regules, Jason, Tosh, Donna, Cowden, Jessica, Kathcart, April, Cummings, James, Paolino, Kristopher, Moon, James, Komisar, Jack, Kamau, Edwin, Oliver, Thomas, Chhoeu, Austin, Murphy, Jitta, Lyke, Kirsten, Laurens, Matthew, Birkett, Ashley, Lee, Cynthia, Weltzin, Rich, Wille-Reece, Ulrike, Sedegah, Martha, Hendriks, Jenny, Versteege, Isabella, Pau, Maria Grazia, Sadoff, Jerold, Vanloubbeeck, Yannick, Lievens, Marc, Heerwegh, Dirk, Moris, Philippe, Guerra Mendoza, Yolanda, Jongert, Erik, Cohen, Joe, Voss, Gerald, Ballou, W Ripley, Vekemans, Johan

“…In an observer blind, phase 2 trial, 55 adults were randomized to receive one dose of Ad35.CS.01 vaccine followed by two doses of RTS,S/AS01 (ARR-group) or…”
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Safety and immunogenicity of a plant-derived recombinant protective antigen (rPA)-based vaccine against Bacillus anthracis: A Phase 1 dose-escalation study in healthy adults by Paolino, Kristopher M., Regules, Jason A., Moon, James E., Ruck, Richard C., Bennett, Jason W., Remich, Shon A., Mills, Kristin T., Lin, Leyi, Washington, Cadeidre N., Fornillos, Ghariwayne A., Lindsey, Changhong Y., O'Brien, Kristan A., Shi, Meng, Mark Jones, R., Green, Brian J., Tottey, Stephen, Chichester, Jessica A., Streatfield, Stephen J., Yusibov, Vidadi

“…•Assessment of plant-produced recombinant PA83 antigen in humans.•All dose ranges tested were safe and immunogenic.•Immunogenicity is dose dependent and peaked…”
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Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy by Bennett, Jason W, Yadava, Anjali, Tosh, Donna, Sattabongkot, Jetsumon, Komisar, Jack, Ware, Lisa A, McCarthy, William F, Cowden, Jessica J, Regules, Jason, Spring, Michele D, Paolino, Kristopher, Hartzell, Joshua D, Cummings, James F, Richie, Thomas L, Lumsden, Joanne, Kamau, Edwin, Murphy, Jittawadee, Lee, Cynthia, Parekh, Falgunee, Birkett, Ashley, Cohen, Joe, Ballou, W Ripley, Polhemus, Mark E, Vanloubbeeck, Yannick F, Vekemans, Johan, Ockenhouse, Christian F

“…A vaccine to prevent infection and disease caused by Plasmodium vivax is needed both to reduce the morbidity caused by this parasite and as a key component in…”
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Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population by Spring, Michele D, Sousa, Jason C, Li, Qigui, Darko, Christian A, Morrison, Meshell N, Marcsisin, Sean R, Mills, Kristin T, Potter, Brittney M, Paolino, Kristopher M, Twomey, Patrick S, Moon, James E, Tosh, Donna M, Cicatelli, Susan B, Froude, Jeffrey W, Pybus, Brandon S, Oliver, Thomas G, McCarthy, William F, Waters, Norman C, Smith, Philip L, Reichard, Gregory A, Bennett, Jason W

“…Abstract Background Plasmodium vivax malaria requires a 2-week course of primaquine (PQ) for radical cure. Evidence suggests that the hepatic isoenzyme…”
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A flow cytometry based assay that simultaneously measures cytotoxicity and monocyte mediated antibody dependent effector activity by Alrubayyi, Aljawharah, Schuetz, Alexandra, Lal, Kerri G., Jongrakthaitae, Surat, Paolino, Kristopher M., Ake, Julie A., Robb, Merlin L., de Souza, Mark S., Michael, Nelson L., Paquin-Proulx, Dominic, Eller, Michael A.

“…Antibody effector functions such as antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP) are considered…”
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Protection against Plasmodium falciparum malaria by PfSPZ Vaccine by Epstein, Judith E, Paolino, Kristopher M, Richie, Thomas L, Sedegah, Martha, Singer, Alexandra, Ruben, Adam J, Chakravarty, Sumana, Stafford, April, Ruck, Richard C, Eappen, Abraham G, Li, Tao, Billingsley, Peter F, Manoj, Anita, Silva, Joana C, Moser, Kara, Nielsen, Robin, Tosh, Donna, Cicatelli, Susan, Ganeshan, Harini, Case, Jessica, Padilla, Debbie, Davidson, Silas, Garver, Lindsey, Saverino, Elizabeth, Murshedkar, Tooba, Gunasekera, Anusha, Twomey, Patrick S, Reyes, Sharina, Moon, James E, James, Eric R, Kc, Natasha, Li, Minglin, Abot, Esteban, Belmonte, Arnel, Hauns, Kevin, Belmonte, Maria, Huang, Jun, Vasquez, Carlos, Remich, Shon, Carrington, Mary, Abebe, Yonas, Tillman, Amy, Hickey, Bradley, Regules, Jason, Villasante, Eileen, Sim, B Kim Lee, Hoffman, Stephen L

“…: A radiation-attenuated (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the…”
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Hydroxychloroquine with or without azithromycin for treatment of early SARS-CoV-2 infection among high-risk outpatient adults: A randomized clinical trial by Johnston, Christine, Brown, Elizabeth R., Stewart, Jenell, Karita, Helen C.Stankiewicz, Kissinger, Patricia J., Dwyer, John, Hosek, Sybil, Oyedele, Temitope, Paasche-Orlow, Michael K., Paolino, Kristopher, Heller, Kate B., Leingang, Hannah, Haugen, Harald S., Dong, Tracy Q., Bershteyn, Anna, Sridhar, Arun R., Poole, Jeanne, Noseworthy, Peter A., Ackerman, Michael J., Morrison, Susan, Greninger, Alexander L., Huang, Meei-Li, Jerome, Keith R., Wener, Mark H., Wald, Anna, Schiffer, Joshua T., Celum, Connie, Chu, Helen Y., Barnabas, Ruanne V., Baeten, Jared M.

“…Treatment options for outpatients with COVID-19 could reduce morbidity and prevent SARS-CoV-2 transmission. In this randomized, double-blind, three-arm (1:1:1)…”
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