Search Results - "PANETTA, J. A"

The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells by Holland, M.L., Panetta, J.A., Hoskins, J.M., Bebawy, M., Roufogalis, B.D., Allen, J.D., Arnold, J.C.

“…Cannabis is the most widely used illicit drug in the world. Cannabinoids are used therapeutically by some patients as they have analgesic, anti-emetic and…”
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LY178002 reduces rat brain damage after transient global forebrain ischemia by CLEMENS, J. A, HO, P. P. K, PANETTA, J. A

“…Several feasible mechanisms have been proposed as sources of neuronal damage from ischemia and subsequent reperfusion. Included among these are oxidative…”
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Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats by Wright, John W., Clemens, James A., Panetta, Jill A., Smalstig, E.Barry, Weatherly, LeighAnn Stubley, Kramár, EniköA., Pederson, Eric S., Mungall, Bruce H., Harding, Joseph W.

“…The antioxidant LY231617 has previously been shown to offer significant protection against postischemic cell death in the hippocampus and corpus striatum of…”
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The antioxidant LY231617 reduces global ischemic neuronal injury in rats by Clemens, J A, Saunders, R D, Ho, P P, Phebus, L A, Panetta, J A

“…In the rat four-vessel occlusion model with 30 minutes of ischemia most agents have failed to be of benefit when given after ischemia. Because postischemia…”
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Characterization of LY231617 Protection Against Hydrogen Peroxide Toxicity by Fuson, Kimberly S., Mark, Robert J., Panetta, Jill A., May, Patrick C.

“…: The compound LY231617 {2,6‐bis(1,1‐dimethylethyl)‐4‐[[(1‐ethyl)amino]methyl]phenol hydrochloride} has been reported to afford significant neuroprotection…”
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Neuroprotection by LY341122, a novel inhibitor of lipid peroxidation, against focal ischemic brain damage in rats by Huh, Pil W, Belayev, Ludmila, Zhao, Weizhao, Clemens, James A, Panetta, Jill A, Busto, Raul, Ginsberg, Myron D

“…LY341122 (2-(3,5-di- t-butyl-4-hydroxyphenyl)-4-(2-(4-methylethylaminomethyl-phenyloxy)ethyl)oxazole) is a potent inhibitor of lipid peroxidation which has…”
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4-Thiazolidinones, potent antioxidants, as antiinflammatory agents by Panetta, J A, Shadle, J K, Phillips, M L, Benslay, D N, Ho, P P

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Tissue distribution of LY231617, an antioxidant with neuroprotectant activity, in the rat by Brewster, M E, Anderson, W R, Estes, K S, Bodor, N S, Pop, E, Panetta, J A

“…The tissue distribution of a butylated phenol antioxidant, LY231617, which has been shown to exert potent neuroprotection action was examined. Preliminary…”
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Preservation of a functionally intact neuronal network after global ischemia by Clemens, J A, Smalstig, E B, Bhagwandin, B, Panetta, J A

“…Although conventional histological techniques demonstrated preservation by drug treatment of neuronal perikarya in the hippocampal CA1 region in animals…”
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Induction of sulfated glycoprotein-2 (clusterin) and glial fibrillary acidic protein (GFAP) RNA expression following transient global ischemia is differentially attenuated by LY231617 by May, Patrick C., Clemens, James A., Panetta, Jill A., Barry Smalstig, E., Stephenson, Diane, Fuson, Kimberly S.

“…Sulfated glycoprotein-2 (SGP-2) is a secreted glycoprotein that along with GFAP has emerged as a prominent molecular marker of neurodegeneration. In the…”
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Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia by O' Neill, Michael J, Hicks, Caroline, Ward, Mark, Panetta, Jill A

“…Recent studies have shown that the novel antioxidant LY231617 protects against ischaemia-induced neuronal damage in rat models of global cerebral ischaemia. In…”
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Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig by Ho, P P, Bertsch, B, Esterman, M, Panetta, J A

“…Anaphylactic shock was induced in actively sensitized guinea pigs by free inhalation of a high dose of ovalbumin (10 mg/ml) aerosol. Tibenelast (LY186655),…”
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Neuroprotection by antioxidants in models of global and focal ischemia by Clemens, J A, Panetta, J A

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The anti-inflammatory effects of LY178002 and LY256548 by Panetta, J A, Benslay, D N, Phillips, M L, Towner, R D, Bertsch, B, Wang, L, Ho, P P

“…LY178002 (5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene-4-thiazolidinon e) and its N-methyl analog, LY256548, inhibit the enzymatic activity of…”
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Novel antioxidant therapy for cerebral ischemia-reperfusion injury by Panetta, J A, Clemens, J A

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Inhibition of IL-1 induced articular inflammation of rats by 4-aminothiazolidines, LY 221068 and LY 269415 by Chandrasekhar, S, Panetta, J A, Bendele, A M

“…LY 221068 and LY 269415 are representative compounds from a chemical series of 4-aminothiazolidines, with potent antioxidant properties in vitro. We have…”
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Redox targeting of LY231617, an antioxidant with potential use in the treatment of brain damage by Pop, Emil, Soti, Ferenc, Anderson, Wesley R., Panetta, Jill A., Estes, Kerry S., Bodor, Nicholas S., Brewster, Marcus E.

“…Several brain-targeting chemical delivery systems (CDS) based on a dihydropyridine ⇌ pyridinium salt-type targetor were synthesized and evaluated for LY231617…”
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Kinetic resolution of a racemic sulfide by enantioselective sulfoxide formation by Phillips, Michael L, Berry, Donnis M, Panetta, Jill A

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Anti-inflammatory effects of LY221068 and LY269415 by Panetta, J A, Benslay, D N, Shadle, J K, Towner, R D, Ho, P P

“…LY221068, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxy phenyl]methylene]-3-(dimethylamino)-4-thiazolidinone, and the monomethylamino analog, LY269415, are…”
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Cardiovascular effect and stimulus-dependent inhibition of superoxide generation from human neutrophils by tibenelast, 5,6-diethoxybenzo(b)thiophene-2-carboxylic acid, sodium salt (LY186655) by Ho, P P, Wang, L Y, Towner, R D, Hayes, S J, Pollock, D, Bowling, N, Wyss, V, Panetta, J A

“…Tibenelast (LY186655), 5,6,-diethoxybenzo(b)thiophene-2-carboxylic acid, sodium salt, is an orally active anti-anaphylactic compound in guinea pigs, and has…”
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