Search Results - "PANDREA, Ivona"

CCR5 as a Coreceptor for Human Immunodeficiency Virus and Simian Immunodeficiency Viruses: A Prototypic Love-Hate Affair by Jasinska, Anna J, Pandrea, Ivona, Apetrei, Cristian

“…CCR5, a chemokine receptor central for orchestrating lymphocyte/cell migration to the sites of inflammation and to the immunosurveillance, is involved in the…”
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Walk on the wild side: SIV infection in African non-human primate hosts-from the field to the laboratory by Jasinska, Anna J, Apetrei, Cristian, Pandrea, Ivona

“…HIV emerged following cross-species transmissions of simian immunodeficiency viruses (SIVs) that naturally infect non-human primates (NHPs) from Africa. While…”
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The Hitchhiker Guide to CD4 + T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4 + T Cells in SIV and HIV Infection by Le Hingrat, Quentin, Sereti, Irini, Landay, Alan L, Pandrea, Ivona, Apetrei, Cristian

“…CD4 T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency virus (SIV) infections. It occurs early, is massive at mucosal sites,…”
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Regulatory T Cells As Potential Targets for HIV Cure Research by Kleinman, Adam J, Sivanandham, Ranjit, Pandrea, Ivona, Chougnet, Claire A, Apetrei, Cristian

“…T regulatory cells (Tregs) are a key component of the immune system, which maintain a delicate balance between overactive responses and immunosuppression. As…”
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So Pathogenic or So What?-A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research by Kleinman, Adam J, Pandrea, Ivona, Apetrei, Cristian

“…HIV infection requires lifelong antiretroviral therapy (ART) to control disease progression. Although ART has greatly extended the life expectancy of persons…”
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CD8+ T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production by Policicchio, Benjamin B., Cardozo-Ojeda, Erwing Fabian, Xu, Cuiling, Ma, Dongzhu, He, Tianyu, Raehtz, Kevin D., Sivanandham, Ranjit, Kleinman, Adam J., Perelson, Alan S., Apetrei, Cristian, Pandrea, Ivona, Ribeiro, Ruy M.

“…Whether CD8 + T lymphocytes control human immunodeficiency virus infection by cytopathic or non-cytopathic mechanisms is not fully understood. Multiple studies…”
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Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication by Kristoff, Jan, Haret-Richter, George, Ma, Dongzhu, Ribeiro, Ruy M, Xu, Cuiling, Cornell, Elaine, Stock, Jennifer L, He, Tianyu, Mobley, Adam D, Ross, Samantha, Trichel, Anita, Wilson, Cara, Tracy, Russell, Landay, Alan, Apetrei, Cristian, Pandrea, Ivona

“…Damage to the intestinal mucosa results in the translocation of microbes from the intestinal lumen into the circulation. Microbial translocation has been…”
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Making a Monkey out of Human Immunodeficiency Virus/Simian Immunodeficiency Virus Pathogenesis: Immune Cell Depletion Experiments as a Tool to Understand the Immune Correlates of Protection and Pathogenicity in HIV Infection by Symmonds, Jen, Gaufin, Thaidra, Xu, Cuiling, Raehtz, Kevin D, Ribeiro, Ruy M, Pandrea, Ivona, Apetrei, Cristian

“…Understanding the underlying mechanisms of HIV pathogenesis is critical for designing successful HIV vaccines and cure strategies. However, achieving this goal…”
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Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection by Favre, David, Lederer, Sharon, Kanwar, Bittoo, Ma, Zhong-Min, Proll, Sean, Kasakow, Zeljka, Mold, Jeff, Swainson, Louise, Barbour, Jason D, Baskin, Carole R, Palermo, Robert, Pandrea, Ivona, Miller, Christopher J, Katze, Michael G, McCune, Joseph M

“…Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand…”
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African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity by Raehtz, Kevin D, Barrenäs, Fredrik, Xu, Cuiling, Busman-Sahay, Kathleen, Valentine, Audrey, Law, Lynn, Ma, Dongzhu, Policicchio, Benjamin B, Wijewardana, Viskam, Brocca-Cofano, Egidio, Trichel, Anita, Gale, Jr, Michael, Keele, Brandon F, Estes, Jacob D, Apetrei, Cristian, Pandrea, Ivona

“…Unlike HIV infection, SIV infection is generally nonpathogenic in natural hosts, such as African green monkeys (AGMs), despite life-long high viral…”
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Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys by Le Hingrat, Quentin, Sette, Paola, Xu, Cuiling, Rahmberg, Andrew R., Tarnus, Lilas, Annapureddy, Haritha, Kleinman, Adam, Brocca-Cofano, Egidio, Sivanandham, Ranjit, Sivanandham, Sindhuja, He, Tianyu, Capreri, Daniel J., Ma, Dongzhu, Estes, Jacob D., Brenchley, Jason M., Apetrei, Cristian, Pandrea, Ivona

“…CD4 + T-cell depletion is a hallmark of HIV infection, leading to impairment of cellular immunity and opportunistic infections, but its contribution to…”
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Acute Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian Immunodeficiency Virus Virulence by Pandrea, Ivona V, Gautam, Rajeev, Ribeiro, Ruy M, Brenchley, Jason M, Butler, Isolde F, Pattison, Melissa, Rasmussen, Terri, Marx, Preston A, Silvestri, Guido, Lackner, Andrew A, Perelson, Alan S, Douek, Daniel C, Veazey, Ronald S, Apetrei, Cristian

“…The predictive value of acute gut-associated lymphoid tissue (GALT) CD4+ T cell depletion in lentiviral infections was assessed by comparing three animal…”
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Tetravalent SARS-CoV-2 S1 subunit protein vaccination elicits robust humoral and cellular immune responses in SIV-infected rhesus macaque controllers by Khan, Muhammad S, Kim, Eun, Le Hingrat, Quentin, Kleinman, Adam, Ferrari, Alessandro, Sammartino, Jose C, Percivalle, Elena, Xu, Cuiling, Huang, Shaohua, Kenniston, Thomas W, Cassaniti, Irene, Baldanti, Fausto, Pandrea, Ivona, Gambotto, Andrea, Apetrei, Cristian

“…The study provides important insights into the immunogenicity and efficacy of a tetravalent protein subunit vaccine candidate against severe acute respiratory…”
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Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts by Silvestri, Guido, Sodora, Donald L, Allan, Jonathan S, Apetrei, Cristian, Brenchley, Jason M, Douek, Daniel C, Else, James G, Estes, Jacob D, Hahn, Beatrice H, Hirsch, Vanessa M, Kaur, Amitinder, Kirchhoff, Frank, Muller-Trutwin, Michaela, Pandrea, Ivona, Schmitz, Jörn E

“…The design of an effective AIDS vaccine has eluded the efforts of the scientific community to the point that alternative approaches to classic vaccine…”
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Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus) by Jasinska, Anna J., Pandrea, Ivona, He, Tianyu, Benjamin, Cassandra, Newton, Maurice, Lee, Jen Chieh, Freimer, Nelson B., Coppola, Giovanni, Jentsch, James D.

“…Psychosocial stressors - life events that challenge social support and relationships - represent powerful risk factors for human disease; included amongst…”
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I've looked at gut from both sides now: Gastrointestinal tract involvement in the pathogenesis of SARS-CoV-2 and HIV/SIV infections by Pandrea, Ivona, Brooks, Kelsie, Desai, Rahul P, Tare, Minali, Brenchley, Jason M, Apetrei, Cristian

“…The lumen of the gastrointestinal (GI) tract contains an incredibly diverse and extensive collection of microorganisms that can directly stimulate the immune…”
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Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus by Ma, Henry, Albe, Joseph R, Gilliland, Theron, McMillen, Cynthia M, Gardner, Christina L, Boyles, Devin A, Cottle, Emily L, Dunn, Matthew D, Lundy, Jeneveve D, Salama, Noah, O'Malley, Katherine J, Pandrea, Ivona, Teichert, Tobias, Barrick, Stacey, Klimstra, William B, Hartman, Amy L, Reed, Douglas S

“…Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus…”
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Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control by Barrenas, Fredrik, Raehtz, Kevin, Xu, Cuiling, Law, Lynn, Green, Richard R., Silvestri, Guido, Bosinger, Steven E., Nishida, Andrew, Li, Qingsheng, Lu, Wuxun, Zhang, Jianshui, Thomas, Matthew J., Chang, Jean, Smith, Elise, Weiss, Jeffrey M., Dawoud, Reem A., Richter, George H., Trichel, Anita, Ma, Dongzhu, Peng, Xinxia, Komorowski, Jan, Apetrei, Cristian, Pandrea, Ivona, Gale, Michael

“…Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection. Here, we examined how this outcome is achieved by comparing a…”
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Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys by Gordon, Shari N, Klatt, Nichole R, Bosinger, Steven E, Brenchley, Jason M, Milush, Jeffrey M, Engram, Jessica C, Dunham, Richard M, Paiardini, Mirko, Klucking, Sara, Danesh, Ali, Strobert, Elizabeth A, Apetrei, Cristian, Pandrea, Ivona V, Kelvin, David, Douek, Daniel C, Staprans, Silvija I, Sodora, Donald L, Silvestri, Guido

“…HIV-infected humans and SIV-infected rhesus macaques experience a rapid and dramatic loss of mucosal CD4+ T cells that is considered to be a key determinant of…”
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Functional cure of SIVagm infection in rhesus macaques results in complete recovery of CD4+ T cells and is reverted by CD8+ cell depletion by Pandrea, Ivona, Gaufin, Thaidra, Gautam, Rajeev, Kristoff, Jan, Mandell, Daniel, Montefiori, David, Keele, Brandon F, Ribeiro, Ruy M, Veazey, Ronald S, Apetrei, Cristian

“…Understanding the mechanism of infection control in elite controllers (EC) may shed light on the correlates of control of disease progression in HIV infection…”
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