Search Results - "PANDITHARATNA, Eshini"

Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR by Li, Daphne, Bonner, Erin R., Wierzbicki, Kyle, Panditharatna, Eshini, Huang, Tina, Lulla, Rishi, Mueller, Sabine, Koschmann, Carl, Nazarian, Javad, Saratsis, Amanda M.

“…Diffuse midline glioma (DMG) is a highly morbid pediatric brain tumor. Up to 80% of DMGs harbor mutations in histone H3-encoding genes, associated with poor…”
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Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy by Panditharatna, Eshini, Kilburn, Lindsay B, Aboian, Mariam S, Kambhampati, Madhuri, Gordish-Dressman, Heather, Magge, Suresh N, Gupta, Nalin, Myseros, John S, Hwang, Eugene I, Kline, Cassie, Crawford, John R, Warren, Katherine E, Cha, Soonmee, Liang, Winnie S, Berens, Michael E, Packer, Roger J, Resnick, Adam C, Prados, Michael, Mueller, Sabine, Nazarian, Javad

“…Pediatric diffuse midline glioma (DMG) are highly malignant tumors with poor clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M…”
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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma by Nikbakht, Hamid, Panditharatna, Eshini, Mikael, Leonie G., Li, Rui, Gayden, Tenzin, Osmond, Matthew, Ho, Cheng-Ying, Kambhampati, Madhuri, Hwang, Eugene I., Faury, Damien, Siu, Alan, Papillon-Cavanagh, Simon, Bechet, Denise, Ligon, Keith L., Ellezam, Benjamin, Ingram, Wendy J., Stinson, Caedyn, Moore, Andrew S., Warren, Katherine E., Karamchandani, Jason, Packer, Roger J., Jabado, Nada, Majewski, Jacek, Nazarian, Javad

“…Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address…”
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Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas by Kambhampati, Madhuri, Panditharatna, Eshini, Yadavilli, Sridevi, Saoud, Karim, Lee, Sulgi, Eze, Augustine, Almira-Suarez, M. I., Hancock, Lauren, Bonner, Erin R., Gittens, Jamila, Stampar, Mojca, Gaonkar, Krutika, Resnick, Adam C., Kline, Cassie, Ho, Cheng-Ying, Waanders, Angela J., Georgescu, Maria-Magdalena, Rance, Naomi E., Kim, Yong, Johnson, Courtney, Rood, Brian R., Kilburn, Lindsay B., Hwang, Eugene I., Mueller, Sabine, Packer, Roger J., Bornhorst, Miriam, Nazarian, Javad

“…Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of…”
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VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system by So, Jonathan, Mabe, Nathaniel W, Englinger, Bernhard, Chow, Kin-Hoe, Moyer, Sydney M, Yerrum, Smitha, Trissal, Maria C, Marques, Joana G, Kwon, Jason J, Shim, Brian, Pal, Sangita, Panditharatna, Eshini, Quinn, Thomas, Schaefer, Daniel A, Jeong, Daeun, Mayhew, David L, Hwang, Justin, Beroukhim, Rameen, Ligon, Keith L, Stegmaier, Kimberly, Filbin, Mariella G, Hahn, William C

“…Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9…”
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Somatic Mosaicism of IDH1 R132H Predisposes to Anaplastic Astrocytoma: A Case of Two Siblings by Lee, Sulgi, Kambhampati, Madhuri, Almira-Suarez, M Isabel, Ho, Cheng-Ying, Panditharatna, Eshini, Berger, Seth I, Turner, Joyce, Van Mater, David, Kilburn, Lindsay, Packer, Roger J, Myseros, John S, Vilain, Eric, Nazarian, Javad, Bornhorst, Miriam

“…Anaplastic astrocytomas are aggressive glial cancers that present poor prognosis and high recurrence. Heterozygous IDH1 R132H mutations are common in…”
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The growing role of epigenetics in childhood cancers by Panditharatna, Eshini, Filbin, Mariella G.

“…Altered epigenetics is central to oncogenesis in many pediatric cancers. Aberrant epigenetic states are induced by mutations in histones or epigenetic…”
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DIPG-26. Targeted Protein Degradation of LSD1 synergizes with HDAC inhibitors in Diffuse Intrinsic Pontine Glioma by Groves, Andrew, Poetschke, Rebecca, Mire, Hafsa, Panditharatna, Eshini, Guzman, Maria Tarazona, Qi, Jun, Filbin, Mariella

“…Diffuse intrinsic pontine glioma (DIPG) remains one of the most lethal brain tumors in all of childhood with no effective treatments besides radiation, which…”
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A pilot precision medicine trial for children with diffuse intrinsic pontine glioma—PNOC003: A report from the Pacific Pediatric Neuro‐Oncology Consortium by Mueller, Sabine, Jain, Payal, Liang, Winnie S., Kilburn, Lindsay, Kline, Cassie, Gupta, Nalin, Panditharatna, Eshini, Magge, Suresh N., Zhang, Bo, Zhu, Yuankun, Crawford, John R., Banerjee, Anu, Nazemi, Kellie, Packer, Roger J., Petritsch, Claudia K., Truffaux, Nathalene, Roos, Alison, Nasser, Sara, Phillips, Joanna J., Solomon, David, Molinaro, Annette, Waanders, Angela J., Byron, Sara A., Berens, Michael E., Kuhn, John, Nazarian, Javad, Prados, Michael, Resnick, Adam C.

“…This clinical trial evaluated whether whole exome sequencing (WES) and RNA sequencing (RNAseq) of paired normal and tumor tissues could be incorporated into a…”
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The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location by Liu, Ilon, Jiang, Li, Samuelsson, Erik R., Marco Salas, Sergio, Beck, Alexander, Hack, Olivia A., Jeong, Daeun, Shaw, McKenzie L., Englinger, Bernhard, LaBelle, Jenna, Mire, Hafsa M., Madlener, Sibylle, Mayr, Lisa, Quezada, Michael A., Trissal, Maria, Panditharatna, Eshini, Ernst, Kati J., Vogelzang, Jayne, Gatesman, Taylor A., Halbert, Matthew E., Palova, Hana, Pokorna, Petra, Sterba, Jaroslav, Slaby, Ondrej, Geyeregger, Rene, Diaz, Aaron, Findlay, Izac J., Dun, Matthew D., Resnick, Adam, Suvà, Mario L., Jones, David T. W., Agnihotri, Sameer, Svedlund, Jessica, Koschmann, Carl, Haberler, Christine, Czech, Thomas, Slavc, Irene, Cotter, Jennifer A., Ligon, Keith L., Alexandrescu, Sanda, Yung, W. K. Alfred, Arrillaga-Romany, Isabel, Gojo, Johannes, Monje, Michelle, Nilsson, Mats, Filbin, Mariella G.

“…Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly…”
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PDTM-07. DETECTION OF IDH1 R132H MOSAICISM IN ANAPLASTIC ASTROCYTOMA PATIENTS by Lee, Sulgi, Bornhorst, Miriam, Panditharatna, Eshini, Kambhampati, Madhuri, Nazarian, Javad

“…Abstract Anaplastic astrocytomas are aggressive cancers of glial cells that present poor prognosis and high recurrence. Heterozygous mutations in IDH1 and IDH2…”
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Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas by Przystal, Justyna M, Cianciolo Cosentino, Chiara, Yadavilli, Sridevi, Zhang, Jie, Laternser, Sandra, Bonner, Erin R, Prasad, Rachna, Dawood, Adam A, Lobeto, Nina, Chin Chong, Wai, Biery, Matt C, Myers, Carrie, Olson, James M, Panditharatna, Eshini, Kritzer, Bettina, Mourabit, Sulayman, Vitanza, Nicholas A, Filbin, Mariella G, de Iuliis, Geoffry N, Dun, Matthew D, Koschmann, Carl, Cain, Jason E, Grotzer, Michael A, Waszak, Sebastian M, Mueller, Sabine, Nazarian, Javad

“…Abstract Background Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a…”
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DDEL-04. Pharmacokinetic/Pharmacodynamic analysis of the DNA methyltransferase inhibitor 5-azacytidine shows adequate brain tissue penetration with intravenous administration in a DIPG mouse patient-derived xenograft model by Groves, Andrew, Jones, Kristen, Cameron, Amy, Panditharatna, Eshini, Morrow, Murry, Mozarsky, Brett, McCully, Cynthia, Peer, Cody, De Nguyen, Quang, Filbin, Mariella, Warren, Katherine

“…One of the biggest obstacles in developing effective therapies for CNS tumors is drug delivery due to the enigmatic challenge of penetrating the blood-brain…”
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GENE-20. MULTI-GENE MUTATION PROFILING OF PEDIATRIC MIDLINE GLIOMAS USING PATIENT LIQUID BIOPSY by Bonner, Erin, Panditharatna, Eshini, Kambhampati, Madhuri, Virata, Michael, Singh, Priyam, Prados, Michael, Mueller, Sabine, Nazarian, Javad

“…Abstract INTRODUCTION: Molecular profiling of the tumor genome is critical for diagnosis and clinical management of CNS tumors. In the case of pediatric…”
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Addendum: Histological and molecular analysis of a progressive diffuse intrinsic pontine glioma and synchronous metastatic lesions: a case report by Nazarian, Javad, Mason, Gary E, Ho, Cheng Ying, Panditharatna, Eshini, Kambhampati, Madhuri, Vezina, L Gilbert, Packer, Roger J, Hwang, Eugene I

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PDTM-42. CROSS-PLATFORM PROFILING OF ctDNA USING ddPCR: STANDARDIZATION OF THE LIQUID BIOPSY FOR PEDIATRIC DIFFUSE MIDLINE GLIOMA by Li, Daphne, Bonner, Erin, Stallard, Stefanie, Panditharatna, Eshini, Huang, Tina, Lulla, Rishi, Koschmann, Carl, Nazarian, Javad, Saratsis, Amanda

“…Abstract INTRODUCTION Pediatric diffuse midline glioma (DMG) with histone H3 mutations (80%), are highly morbid tumors with poor response to therapy. We…”
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DIPG-31. TUMOR SURVEILLANCE USING LIQUID BIOME IN PEDIATRIC HIGH GRADE GLIOMAS by Bonner, Erin, Panditharatna, Eshini, Kambhampati, Madhuri, Van Gool, Stefaan, Stuecker, Wilfried, Packer, Roger, Nazarian, Javad

“…Abstract Immunotherapy is currently being used to treat pediatric brain cancer, though its efficacy in treating patients with diffuse intrinsic pontine glioma…”
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BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma by Panditharatna, Eshini, Marques, Joana G, Wang, Tingjian, Trissal, Maria C, Liu, Ilon, Jiang, Li, Beck, Alexander, Groves, Andrew, Dharia, Neekesh V, Li, Deyao, Hoffman, Samantha E, Kugener, Guillaume, Shaw, McKenzie L, Mire, Hafsa M, Hack, Olivia A, Dempster, Joshua M, Lareau, Caleb, Dai, Lingling, Sigua, Logan H, Quezada, Michael A, Stanton, Ann-Catherine J, Wyatt, Meghan, Kalani, Zohra, Goodale, Amy, Vazquez, Francisca, Piccioni, Federica, Doench, John G, Root, David E, Anastas, Jamie N, Jones, Kristen L, Conway, Amy Saur, Stopka, Sylwia, Regan, Michael S, Liang, Yu, Seo, Hyuk-Soo, Song, Kijun, Bashyal, Puspalata, Jerome, William P, Mathewson, Nathan D, Dhe-Paganon, Sirano, Suvà, Mario L, Carcaboso, Angel M, Lavarino, Cinzia, Mora, Jaume, Nguyen, Quang-De, Ligon, Keith L, Shi, Yang, Agnihotri, Sameer, Agar, Nathalie Y R, Stegmaier, Kimberly, Stiles, Charles D, Monje, Michelle, Golub, Todd R, Qi, Jun, Filbin, Mariella G

“…Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are refractory to standard-of-care therapeutic modalities. The…”
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A Phase I Trial of Imetelstat in Children with Refractory or Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Study (ADVL1112) by THOMPSON, Patrick A, DRISSI, Rachid, BLANEY, Susan M, MUSCAL, Jodi A, PANDITHARATNA, Eshini, FOULADI, Maryam, INGLE, Ashish M, AHERN, Charlotte H, REID, Joel M, TONG LIN, WEIGEL, Brenda J

“…Imetelstat is a covalently-lipidated 13-mer thiophosphoramidate oligonucleotide that acts as a potent specific inhibitor of telomerase. It binds with high…”
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Abstract 810: Establishing patient derived preclinical in vitro and in vivo models of pediatric brain cancers by Yadavilli, Sridevi, Kambhampati, Madhuri, Gittens, Jamila, Panditharatna, Eshini, Stampar, Mojca, Kilburn, Lindsay B., Magge, Suresh, Packer, Roger J., Nazarian, Javad

“…The recent surge in understanding genomic aberrations of some of the deadliest childhood brain cancers has highlighted the need for robust preclinical models…”
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