Search Results - "PANAYOTATOS, N"

Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing by McDonald, N.Q., Panayotatos, N., Hendrickson, W.A.

“…Ciliary neurotrophic factor (CNTF) promotes the survival and differentiation of developing motor neurons and is a potential therapeutic for treating…”
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Ciliary Neurotrophic Factor Protects Striatal Output Neurons in an Animal Model of Huntington Disease by Anderson, Keith D., Panayotatos, Nikos, Corcoran, Thomas L., Lindsay, Ronald M., Wiegand, Stanley J.

“…Huntington disease is a dominantly inherited, untreatable neurological disorder featuring a progressive loss of striatal output neurons that results in…”
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Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures by Ip, NY, Li, YP, van de Stadt, I, Panayotatos, N, Alderson, RF, Lindsay, RM

“…First described as a survival factor for chick ciliary ganglion neurons, ciliary neurotrophic factor (CNTF) has recently been shown to promote survival of…”
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Microtubule-Associated Protein 2 Kinases, ERK1 and ERK2, Undergo Autophosphorylation on Both Tyrosine and Threonine Residues: Implications for Their Mechanism of Activation by Seger, Rony, Ahn, Natalie G., Boulton, Teri G., Yancopoulos, George D., Panayotatos, Nikos, Radziejewska, Elizabeth, Ericsson, Lowell, Bratlien, Rebecca L., Cobb, Melanie H., Krebs, Edwin G.

“…Microtubule-associated protein 2 kinase (MAP kinase), which exists in several forms, is a protein serine/threonine kinase that participates in a growth…”
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A native cruciform DNA structure probed in bacteria by recombinant T7 endonuclease by Panayotatos, N, Fontaine, A

“…T7 endonuclease preferentially cleaves purified supercoiled pBR322 and colE1 plasmids at the single-stranded regions exposed when palindromic sequences assume…”
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Exchange of a single amino acid interconverts the specific activity and gel mobility of human and rat ciliary neurotrophic factors by Panayotatos, N., Radziejewska, E., Acheson, A., Pearsall, D., Thadani, A., Wong, V.

“…Human and rat ciliary neurotrophic factors (CNTF), which share 85% sequence identity, promote the survival of chicken embryo ciliary ganglia neurons in vitro,…”
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Recombinant human CNTF receptor .alpha.: production, binding stoichiometry, and characterization of its activity as a diffusible factor by Panayotatos, N, Everdeen, D, Liten, A, Somogyi, R, Acheson, A

“…The primary ligand-binding protein (CNTFR alpha) of the multicomponent receptor for ciliary neurotrophic factor was produced in Escherichia coli. Using novel…”
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Characterization and crystallization of recombinant human neurotrophin-4 by FANDL, J. P, TOBKES, N. J, MCDONALD, N. Q, HENDRICKSON, W. A, RYAN, T. E, SOMESH NIGAM, ACHESON, A, CUDNY, H, PANAYOTATOS, N

“…Neurotrophin-4 (NT-4) is the most recently discovered member of the neurotrophin family. We have expressed, refolded, and purified recombinant human NT-4 from…”
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Ciliary neurotrophic factor inhibits brain and peripheral tumor necrosis factor production and, when coadministered with its soluble receptor, protects mice from lipopolysaccharide toxicity by Benigni, F, Villa, P, Demitri, M T, Sacco, S, Sipe, J D, Lagunowich, L, Panayotatos, N, Ghezzi, P

“…The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such…”
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II. A Site-targeted Recombinant Nuclease Probe of DNA Structure by Panayotatos, N, Bãckman, S

“…A genetically engineered lac repressor/T7 endonuclease hybrid protein shows repressor-like binding toward restriction fragments carrying the lac operator. In…”
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An endonuclease specific for single-stranded DNA selectively damages the genomic DNA and induces the SOS response by Panayotatos, N, Fontaine, A

“…A plasmid carrying the bacteriophage T7.3 endonuclease gene under the control of the lacUV5 promoter could be maintained in the transcriptionally active state…”
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I. Biosynthesis of a Repressor/Nuclease Hybrid Protein by Panayotatos, N, Fontaine, A, Bãckman, S

“…The phage T7 endonuclease gene was fused to the 3′ end of the lac repressor gene. The hybrid protein exhibits repressor and nuclease functions in a manner…”
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Outside expertise by Panayotatos, Nikos

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A site-targeted recombinant nuclease probe of DNA structure by Panayotatos, N, Bãckman, S

“…A genetically engineered lac repressor/T7 endonuclease hybrid protein shows repressor-like binding toward restriction fragments carrying the lac operator. In…”
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Vectors with adjustable copy numbers by Panayotatos, N

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Biosynthesis of a repressor/nuclease hybrid protein by Panayotatos, N, Fontaine, A, Baeckman, S

“…The phage T7 endonuclease gene was fused to the 3' end of the lac repressor gene. The hybrid protein exhibits repressor and nuclease functions in a manner…”
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Cloning and localization of the in vitro functional origin of replication of bacteriophage T7 DNA by Panayotatos, N, Wells, R D

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Microwave performance of GaAs-on-Si MESFETs with Si buffer layers by Georgakilas, A., Halkias, G., Christou, A., Papavassiliou, C., Perantinos, G., Konstantinidis, G., Panayotatos, P.N.

“…The incorporation of silicon-buffer layers is shown to be critical in attaining optimized microwave performance for GaAs on silicon MESFETs. A current gain…”
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ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF by Boulton, Teri G, Nye, Steven H, Robbins, David J, Ip, Nancy Y, Radziejewska, Elizabeth, Morgenbesser, Sharon D, DePinho, Ronald A, Panayotatos, Nikos, Cobb, Melanie H, Yancopoulos, George D

“…We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting…”
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The inhibitory effect of phenanthridines on the synthesis of ribonucleic acid catalyzed by deoxyribonucleic acid-dependent ribonucleic acid polymerase by Aktipis, S, Panayotatos, N

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