Search Results - "PANAS, Michael W"

Seizing control: How dense granule effector proteins enable Toxoplasma to take charge by Panas, Michael W., Boothroyd, John C.

“…Control of the host cell is crucial to the Apicomplexan parasite, Toxoplasma gondii, while it grows intracellularly. To achieve this goal, these single‐celled…”
Get full text

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii by Marino, Nicole D, Panas, Michael W, Franco, Magdalena, Theisen, Terence C, Naor, Adit, Rastogi, Suchita, Buchholz, Kerry R, Lorenzi, Hernan A, Boothroyd, John C

“…Toxoplasma gondii is an obligate intracellular parasite that can infect virtually all nucleated cells in warm-blooded animals. The ability of Toxoplasma…”
Get full text

Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids by Panas, Michael W., Jain, Paras, Yang, Hui, Mitra, Shimontini, Biswas, Debasis, Wattam, Alice Rebecca, Letvin, Norman L., Jacobs, William R.

“…Significance A mutant strain of Mycobacterium smegmatis mc ²155 provided the first plasmid transformation platform for any mycobacteria. It has since been used…”
Get full text

Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes by Gillard, Geoffrey O, Bivas-Benita, Maytal, Hovav, Avi-Hai, Grandpre, Lauren E, Panas, Michael W, Seaman, Michael S, Haynes, Barton F, Letvin, Norman L

“…While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are…”
Get full text

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell by Coffey, Michael J, Sleebs, Brad E, Uboldi, Alessandro D, Garnham, Alexandra, Franco, Magdalena, Marino, Nicole D, Panas, Michael W, Ferguson, David Jp, Enciso, Marta, O'Neill, Matthew T, Lopaticki, Sash, Stewart, Rebecca J, Dewson, Grant, Smyth, Gordon K, Smith, Brian J, Masters, Seth L, Boothroyd, John C, Boddey, Justin A, Tonkin, Christopher J

“…Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the…”
Get full text

Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells by Cygan, Alicja M, Theisen, Terence C, Mendoza, Alma G, Marino, Nicole D, Panas, Michael W, Boothroyd, John C

“…is a ubiquitous, intracellular protozoan that extensively modifies infected host cells through secreted effector proteins. Many such effectors must be…”
Get full text

Host MOSPD2 enrichment at the parasitophorous vacuole membrane varies between Toxoplasma strains and involves complex interactions by Ferrel, Abel, Romano, Julia, Panas, Michael W, Coppens, Isabelle, Boothroyd, John C

“…is an obligate, intracellular parasite. Infection of a cell produces a unique niche for the parasite named the parasitophorous vacuole (PV) initially composed…”
Get full text

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes by Panas, Michael W., Xie, Zhihua, Panas, Helen N., Hoener, Marius C., Vallender, Eric J., Miller, Gregory M.

“…Although most research to date on Trace Amine Associated Receptor 1 (TAAR1) has focused on its role in the brain, it has been recognized since its discovery in…”
Get full text

Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques by Sixsmith, Jaimie D, Panas, Michael W, Lee, Sunhee, Gillard, Geoffrey O, White, KeriAnn, Lifton, Michelle A, Balachandran, Harikrishnan, Mach, Linh, Miller, John P, Lavine, Christy, DeMarco, C Todd, Tomaras, Georgia D, Gee, Connie, Porcelli, Steven A, Larsen, Michelle H, Frothingham, Richard, Schmitz, Joern E, Jacobs, Jr, William R, Haynes, Barton F, Letvin, Norman L, Korioth-Schmitz, Birgit

“…Live attenuated nonpathogenic Mycobacterium bovis bacillus Calmette-Guérin (BCG) mediates long-lasting immune responses, has been safely administered as a…”
Get full text

Toxoplasma Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1 by Panas, Michael W, Naor, Adit, Cygan, Alicja M, Boothroyd, John C

“…is an obligate intracellular parasite that establishes a favorable environment in the host cells in which it replicates. We have previously reported that it…”
Get full text

The Impact of a Boosting Immunogen on the Differentiation of Secondary Memory CD8+ T Cells by HOVAV, Avi-Hai, PANAS, Michael W, OSUNA, Christa E, CAYABYAB, Mark J, AUTISSIER, Patrick, LETVIN, Norman L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell's Early Response to Toxoplasma , Including Counteracting MYR1-Independent Effects by Naor, Adit, Panas, Michael W, Marino, Nicole, Coffey, Michael J, Tonkin, Christopher J, Boothroyd, John C

“…The obligate intracellular parasite controls its host cell from within the parasitophorous vacuole (PV) by using a number of diverse effector proteins, a…”
Get full text

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells by Franco, Magdalena, Panas, Michael W, Marino, Nicole D, Lee, Mei-Chong Wendy, Buchholz, Kerry R, Kelly, Felice D, Bednarski, Jeffrey J, Sleckman, Barry P, Pourmand, Nader, Boothroyd, John C

“…The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of host cells it infects, including substantially up-regulating the…”
Get full text

X4 Human Immunodeficiency Virus Type 1 gp120 Down-Modulates Expression and Immunogenicity of Codelivered Antigens by HOVAV, Avi-Hai, SANTOSUOSSO, Michael, XIANG, Shi-Hua, FURMANOV, Karina, LETVIN, Norman L, POZNANSKY, Mark C, BIVAS-BENITA, Maytal, PLAIR, Andre, CHENG, Alex, ELNEKAVE, Mazal, RIGHI, Elda, TAO CHEN, KASHIWAGI, Satoshi, PANAS, Michael W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Rapid Memory CD8+ T-Lymphocyte Induction through Priming with Recombinant Mycobacterium smegmatis by HOVAV, Avi-Hai, CAYABYAB, Mark J, PANAS, Michael W, SANTRA, Sampa, GREENLAND, John, GEIBEN, Ralf, HAYNES, Barton F, JACOBS, William R, LETVIN, Norman L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma- Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase by Panas, Michael W, Ferrel, Abel, Naor, Adit, Tenborg, Elizabeth, Lorenzi, Hernan A, Boothroyd, John C

“…tachyzoites co-opt host cell functions through introduction of a large set of rhoptry- and dense granule-derived effector proteins. These effectors reach the…”
Get full text

Toxoplasma Uses GRA16 To Upregulate Host c-Myc by Panas, Michael W, Boothroyd, John C

“…Manipulation of the host cell is a crucial part of life for many intracellular organisms. We have recently come to appreciate the extent to which the…”
Get full text

Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease by Lahey, Lauren J, Panas, Michael W, Mao, Rong, Delanoy, Michelle, Flanagan, John J, Binder, Steven R, Rebman, Alison W, Montoya, Jose G, Soloski, Mark J, Steere, Allen C, Dattwyler, Raymond J, Arnaboldi, Paul M, Aucott, John N, Robinson, William H

“…The current standard for laboratory diagnosis of Lyme disease in the United States is serologic detection of antibodies against Borrelia burgdorferi. The…”
Get full text

Critical role for IL‐21 in both primary and memory anti‐viral CD8⁺ T‐cell responses by Barker, Brianne R, Gladstone, Michael N, Gillard, Geoffrey O, Panas, Michael W, Letvin, Norman L

“…While it is well established that CD8⁺ T cells generated in the absence of CD4⁺ T cells mediate defective recall responses, the mechanism by which CD4⁺ T cells…”
Get full text

Role for Gr-1+ cells in the control of high-dose Mycobacterium bovis recombinant BCG by Panas, Michael W, Letvin, Norman L

“…Mycobacterium bovis bacillus Calmette-Guérin (BCG) is an attractive target for development as a live vaccine vector delivering transgenic antigens from HIV and…”
Get full text