Search Results - "PALOP, J. A"
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Selenium and clinical trials: new therapeutic evidence for multiple diseases
Published in Current medicinal chemistry (01-10-2011)“…The understanding of the essential role of selenium (Se) in human health has increased substantially in recent decades. Micronutrient deficiencies are very…”
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2
The quinoline imidoselenocarbamate EI201 blocks the AKT/mTOR pathway and targets cancer stem cells leading to a strong antitumor activity
Published in Current medicinal chemistry (01-06-2012)“…Methylimidoselenocarbamates have previously proven to display potent antitumor activities. In the present study we show that these compounds act as multikinase…”
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3
Innovative lead compounds and formulation strategies as newer kinetoplastid therapies
Published in Current medicinal chemistry (01-09-2012)“…The protozoan diseases leishmaniasis, human African trypanosomiasis (HAT) and Chagas disease (CD) are responsible for substantial global morbidity and…”
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4
Kinase regulation by sulfur and selenium containing compounds
Published in Current cancer drug targets (01-05-2011)“…Kinases are enzymes that are involved in a wide-range of cellular targets such as cell proliferation, metabolism, survival and apoptosis. Aberrations in the…”
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5
Thermal stability and decomposition of pharmaceutical compounds
Published in Journal of thermal analysis and calorimetry (01-09-2007)“…Thermal analysis of fusion and decomposition processes were carried out on recently synthetized pharmaceutical compounds in order to establish thermal…”
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New 1-Aryl-3-(4-arylpiperazin-1-yl)propane Derivatives, with Dual Action at 5-HT1A Serotonin Receptors and Serotonin Transporter, as a New Class of Antidepressants
Published in Journal of medicinal chemistry (01-02-2001)“…In a search toward new and efficient antidepressants, 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives were designed, synthesized, and evaluated for 5-HT…”
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7
Hypoxia-Selective Agents Derived from Quinoxaline 1,4-Di-N-oxides
Published in Journal of medicinal chemistry (01-05-1995)“…Hypoxic cells, which are a common feature of solid tumors, but not normal tissues, are resistant to both anticancer drugs and radiation therapy. Thus the…”
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8
Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives
Published in Journal of medicinal chemistry (01-09-1993)“…A series of piperazinylquinoxalines has been synthesized and studied as 5-HT3 receptor antagonists in different preparations. Antagonism to 5-HT in the…”
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9
Strong induction of iodothyronine deiodinases by chemotherapeutic selenocompounds
Published in Metallomics (01-02-2015)“…The biological activity of thyroid hormones (TH) is regulated by selenoenzymes of the iodothyronine deiodinase (DIO) family catalysing TH activating and…”
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10
Mechanism of thermal decomposition of thiourea derivatives
Published in Journal of thermal analysis and calorimetry (01-09-2008)“…The thermal decomposition of a series of compounds has been studied by thermogravimetry, mass spectrometry, nuclear magnetic resonance and elemental analysis…”
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11
Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism
Published in Farmaco (Società chimica italiana : 1989) (01-05-2000)“…It has been suggested that the combination of a selective serotonin reuptake inhibitor (SSRI) and a 5-HT1A receptor antagonist may facilitate the onset of the…”
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12
Synthesis of 2-Piperazinylbenzothiazole and 2-Piperazinylbenzoxazole Derivatives with 5-HT3 Antagonist and 5-HT4 Agonist Properties
Published in Journal of medicinal chemistry (01-04-1994)“…New 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives were prepared and tested as 5-HT3 receptor antagonists. Some of the new compounds…”
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13
Thermal decomposition and stability of quinoline compounds using thermogravimetry and differential scanning calorimetry
Published in Thermochimica acta (01-03-2005)“…Thermal analysis, with DSC and TGA of fusion and decomposition processes of some quinoline compounds were carried out to determine their stability. The…”
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14
Hypoxia-Selective Agents Derived from 2-Quinoxalinecarbonitrile 1,4-Di-N-oxides. 2
Published in Journal of medicinal chemistry (01-10-1995)“…Hypoxic cells are an important target for antitumor therapy because tumors are typically characterized by such cells. Virtually all tumors which are present as…”
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15
New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants
Published in European journal of medicinal chemistry (2001)“…A series of new 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives were synthesized in an attempt to find a new class of antidepressant…”
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16
Synthesis of 3-amino-5H-pyrimido[5,4-b]indol-4-one derivatives
Published in Journal of heterocyclic chemistry (01-03-1987)“…Starting with ethyl 3‐aminoindole‐2‐carboxylate, the synthesis of 3‐amino‐5H‐pyrimido[5,4‐b]indole‐2,4‐dione 5, 3‐amino‐5H‐pyrimido[5,4‐b]indol‐4‐one 10 and…”
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17
About the synthesis of [1,2]diazepinoindole derivatives from ethyl 2-(1-methylindole)acetate, 2-indole and 3-indoleacetohydrazones
Published in Journal of heterocyclic chemistry (01-09-1985)“…The Vilsmeier‐Haack reaction with ethyl 2‐(1‐methylindole)acetate and N,N‐Dimethylamides/phosphorus oxychloride gave (65–85%) of ethyl…”
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18
New hypoxia-selective cytotoxines derived from quinoxaline 1,4-dioxides
Published in Journal of heterocyclic chemistry (01-07-1995)“…A new series of quinoxaline 1,4‐dioxides, structurally related to the benzotriazine tirapazamine 1 have been prepared starting from 5,6‐dichlorobenzofuroxane…”
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19
Synthesis of pyridazino[4,5-b]indole derivatives from 2-(3-carboxy-1-methylindole)acetic acid anhydride
Published in Journal of heterocyclic chemistry (01-01-1986)“…2‐(3‐Carboxy‐1‐methylindole)acetic acid anhydride (1) reacts with aryldiazonium salts to give 85–95% of the corresponding α‐hydrazono anhydrides 2. Treating 2…”
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20
Synthesis of 3H[1,2]diazepino[5,6-b]indole and 3H[1,2]diazepino[4,5-b]indole derivatives
Published in Journal of heterocyclic chemistry (01-03-1984)“…The synthesis of two new derivatives of 3H[1,2]diazepino[5,6‐b]indole, 5 and 11, and one new derivative of 3H[1,2]diazepino[4,5‐b]indole, 16, are described…”
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