Search Results - "PALMIERI, Diane"

CNS metastases in breast cancer: old challenge, new frontiers by Lin, Nancy U, Amiri-Kordestani, Laleh, Palmieri, Diane, Liewehr, David J, Steeg, Patricia S

“…Despite major therapeutic advances in the management of patients with breast cancer, central nervous system (CNS) metastases remain an intractable problem,…”
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The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model by Liu, Hui, Kato, Yukinari, Erzinger, Stephanie A, Kiriakova, Galina M, Qian, Yongzhen, Palmieri, Diane, Steeg, Patricia S, Price, Janet E

“…Brain metastasis is an increasingly common complication for breast cancer patients; approximately 15- 30% of breast cancer patients develop brain metastasis…”
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Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer by LOCKMAN, Paul R, MITTAPALLI, Rajendar K, SUYUN HUANG, PALMIERI, Diane, STEEG, Patricia S, SMITH, Quentin R, TASKAR, Kunal S, RUDRARAJU, Vinay, GRIL, Brunilde, BOHN, Kaci A, ADKINS, Chris E, ROBERTS, Amanda, THORSHEIM, Helen R, GAASCH, Julie A

“…Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic…”
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Breast Cancer Metastasis to the Central Nervous System by Weil, Robert J., Palmieri, Diane C., Bronder, Julie L., Stark, Andreas M., Steeg, Patricia S.

“…Clinically symptomatic metastases to the central nervous system (CNS) occur in ∼10 to 15% of patients with metastatic beast cancer. CNS metastases are…”
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Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer by Taskar, Kunal S., Rudraraju, Vinay, Mittapalli, Rajendar K., Samala, Ramakrishna, Thorsheim, Helen R., Lockman, Julie, Gril, Brunilde, Hua, Emily, Palmieri, Diane, Polli, Joseph W., Castellino, Stephen, Rubin, Stephen D., Lockman, Paul R., Steeg, Patricia S., Smith, Quentin R.

“…ABSTRACT Purpose Lapatinib, a small molecule EGFR/HER2 inhibitor, partially inhibits the outgrowth of HER2+ brain metastases in preclinical models and in a…”
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Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer by MARSHALL, Jean-Claude A, COLLINS, Joshua W, MURONE, Maximilien, STEEG, Patricia S, NAKAYAMA, Joji, HORAK, Christine E, LIEWEHR, David J, STEINBERG, Seth M, ALBAUGH, Mary, VIDAL-VANACLOCHA, Fernando, PALMIERI, Diane, BARBIER, Maryse

“…Previous studies identified the human nonmetastatic gene 23 (NME1, hereafter Nm23-H1) as the first metastasis suppressor gene. An inverse relationship between…”
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Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain by PALMIERI, Diane, BRONDER, Julie L, VORTMEYER, Alexander O, STEINBERG, Seth M, ALDAPE, Kenneth, STEEG, Patricia S, HERRING, Jeanne M, YONEDA, Toshiyuki, WEIL, Robert J, STARK, Andreas M, KUREK, Raffael, VEGA-VALLE, Eleazar, FEIGENBAUM, Lionel, HALVERSON, Douglas

“…Retrospective studies of breast cancer patients suggest that primary tumor Her-2 overexpression or trastuzumab therapy is associated with a devastating…”
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Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis by Palmieri, Diane, Fitzgerald, Daniel, Shreeve, S Martin, Hua, Emily, Bronder, Julie L, Weil, Robert J, Davis, Sean, Stark, Andreas M, Merino, Maria J, Kurek, Raffael, Mehdorn, H Maximilian, Davis, Gary, Steinberg, Seth M, Meltzer, Paul S, Aldape, Kenneth, Steeg, Patricia S

“…Brain metastases of breast cancer seem to be increasingin incidence as systemic therapy improves. Metastatic disease in the brain is associated with high…”
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Profound Prevention of Experimental Brain Metastases of Breast Cancer by Temozolomide in an MGMT-Dependent Manner by PALMIERI, Diane, DUCHNOWSKA, Renata, LIEWEHR, David J, STEINBERG, Seth M, JASSEM, Jacek, STEEG, Patricia S, WODITSCHKA, Stephan, HUA, Emily, YONGZHEN QIAN, BIERNAT, Wojciech, SOSINSKA-MIELCAREK, Katarzyna, GRIL, Brunilde, STARK, Andreas M, HEWITT, Stephen M

“…Brain metastases of breast cancer cause neurocognitive damage and are incurable. We evaluated a role for temozolomide in the prevention of brain metastases of…”
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The Biology of Metastasis to a Sanctuary Site by Palmieri, Diane, Chambers, Ann F, Felding-Habermann, Brunhilde, Huang, Suyun, Steeg, Patricia S

“…Metastasis to the brain is prevalent in solid tumors and lymphomas, and is associated with shortened survival. The brain is regarded as a sanctuary site for…”
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Pazopanib Reveals a Role for Tumor Cell B-Raf in the Prevention of HER2+ Breast Cancer Brain Metastasis by GRIL, Brunilde, PALMIERI, Diane, YONG QIAN, SMART, Deedee, ILEVA, Lilia, LIEWEHR, David J, STEINBERG, Seth M, STEEG, Patricia S

“…Brain metastases of breast cancer contribute significantly to patient morbidity and mortality. We have tested pazopanib, a recently approved antiangiogenic…”
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Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization by Fitzgerald, Daniel P., Palmieri, Diane, Hua, Emily, Hargrave, Elizabeth, Herring, Jeanne M., Qian, Yongzhen, Vega-Valle, Eleazar, Weil, Robert J., Stark, Andreas M., Vortmeyer, Alexander O., Steeg, Patricia S.

“…Interactions between tumor cells and the microenvironment are crucial to tumor formation and metastasis. The central nervous system serves as a “sanctuary”…”
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In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain by Heyn, Chris, Ronald, John A., Ramadan, Soha S., Snir, Jonatan A., Barry, Andrea M., MacKenzie, Lisa T., Mikulis, David J., Palmieri, Diane, Bronder, Julie L., Steeg, Patricia S., Yoneda, Toshiyuki, MacDonald, Ian C., Chambers, Ann F., Rutt, Brian K., Foster, Paula J.

“…Metastasis (the spread of cancer from a primary tumor to secondary organs) is responsible for most cancer deaths. The ability to follow the fate of a…”
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Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks by PALMIERI, Diane, LOCKMAN, Paul R, TASKAR, Kunal S, RUDRARAJU, Vinay, MITTAPALLI, Rajendar K, GAASCH, Julie A, BOHN, Kaci A, THORSHEIM, Helen R, LIEWEHR, David J, DAVIS, Sean, REILLY, John F, WALKER, Robert, THOMAS, Fancy C, BRONDER, Julie L, FEIGENBAUM, Lionel, STEINBERG, Seth M, CAMPHAUSEN, Kevin, MELTZER, Paul S, RICHON, Victoria M, SMITH, Quentin R, STEEG, Patricia S, HUA, Emily, HERRING, Jeanne, HARGRAVE, Elizabeth, JOHNSON, Matthew, FLORES, Natasha, YONGZHEN QIAN, VEGA-VALLE, Eleazar

“…Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few…”
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Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts by Baschnagel, Andrew, Russo, Andrea, Burgan, William E, Carter, Donna, Beam, Katie, Palmieri, Diane, Steeg, Patricia S, Tofilon, Philip, Camphausen, Kevin

“…Vorinostat (suberoylanilide hydroxamic acid), a histone deacetylase inhibitor, is currently undergoing clinical evaluation as therapy for cancer. We…”
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Opposing Effects of Pigment Epithelium-Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage by FITZGERALD, Daniel P, SUBRAMANIAN, Preeti, HERMAN, Mary M, CAMPHAUSEN, Kevin, PALMIERI, Diane, PATRICIA BECERRA, S, STEEG, Patricia S, DESHPANDE, Monika, GRAVES, Christian, GORDON, Ira, YONGZHEN QIAN, SNITKOVSKY, Yeva, LIEWEHR, David J, STEINBERG, Seth M, PALTAN-ORTIZ, José D

“…Brain metastases are a significant cause of morbidity and mortality for patients with cancer, yet preventative and therapeutic options remain an unmet need…”
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Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2 by HORAK, Christine E, JONG HEUN LEE, MELTZER, Paul S, STEEG, Patricia S, ELKAHLOUN, Abdel G, BOISSAN, Mathieu, DUMONT, Sylvie, MAGA, Tara K, ARNAUD-DABERNAT, Sandrine, PALMIERI, Diane, STETLER-STEVENSON, William G, LACOMBE, Marie-Lise

“…Exogenous overexpression of the metastasis suppressor gene Nm23-H1 reduces the metastatic potential of multiple types of cancer cells and suppresses in vitro…”
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Nm23-H1 Metastasis Suppressor Phosphorylation of Kinase Suppressor of Ras via a Histidine Protein Kinase Pathway by Hartsough, Melanie T, Morrison, Deborah K, Salerno, Massimiliano, Palmieri, Diane, Ouatas, Taoufik, Mair, Michael, Patrick, Jilma, Steeg, Patricia S

“…The metastasis-suppressive activity of Nm23-H1 was previously correlated with its in vitro histidine protein kinase activity, but physiological substrates have…”
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The B-Raf status of tumor cells may be a significant determinant of both antitumor and anti-angiogenic effects of pazopanib in xenograft tumor models by Gril, Brunilde, Palmieri, Diane, Qian, Yong, Anwar, Talha, Ileva, Lilia, Bernardo, Marcelino, Choyke, Peter, Liewehr, David J, Steinberg, Seth M, Steeg, Patricia S

“…Pazopanib is an FDA approved Vascular Endothelial Growth Factor Receptor inhibitor. We previously reported that it also inhibits tumor cell B-Raf activity in…”
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Nm23-H1 Metastasis Suppressor Expression Level Influences the Binding Properties, Stability, and Function of the Kinase Suppressor of Ras1 (KSR1) Erk Scaffold in Breast Carcinoma Cells by Salerno, Massimiliano, Palmieri, Diane, Bouadis, Amina, Halverson, Douglas, Steeg, Patricia S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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