Search Results - "PALLAST, Stefanie"

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke by Yigitkanli, Kazim, Pekcec, Anton, Karatas, Hulya, Pallast, Stefanie, Mandeville, Emiri, Joshi, Netra, Smirnova, Natalya, Gazaryan, Irina, Ratan, Rajiv R., Witztum, Joseph L., Montaner, Joan, Holman, Theodore R., Lo, Eng H., van Leyen, Klaus

“…Targeting newly identified damage pathways in the ischemic brain can help to circumvent the currently severe limitations of acute stroke therapy. Here we show…”
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12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress by Pallast, Stefanie, Arai, Ken, Wang, Xiaoying, Lo, Eng H, van Leyen, Klaus

“…12/15-Lipoxygenase (12/15-LOX) is an important mediator of brain injury following experimental stroke in rodents. It contributes to neuronal death, but the…”
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Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12 15-lipoxygenase-dependent organelle damage pathway by Pallast, Stefanie, Arai, Ken, Pekcec, Anton, Yigitkanli, Kazim, Yu, Zhanyang, Wang, Xiaoying, Lo, Eng H, van Leyen, Klaus

“…12/15-lipoxygenase (12/15-LOX) contributes to acute neuronal injury and edema formation in mouse models of middle cerebral artery occlusion (MCAO). The…”
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Experimental Model of Warfarin-Associated Intracerebral Hemorrhage by FOERCH, Christian, ARAI, Ken, GUANG JIN, PARK, Kyung-Pil, PALLAST, Stefanie, VAN LEYEN, Klaus, LO, Eng H

“…Future demographic changes predict an increase in the number of patients with atrial fibrillation. As long-term anticoagulation for the prevention of ischemic…”
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Gamma‐glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood–brain barrier permeability after experimental brain trauma by Lok, Josephine, Leung, Wendy, Zhao, Song, Pallast, Stefanie, van Leyen, Klaus, Guo, Shuzhen, Wang, Xiaoying, Yalcin, Ayfer, Lo, Eng H.

“…J. Neurochem. (2011) 118, 248–255. Oxidative stress is a pathway of injury that is common to almost all neurological conditions. Hence, methods to scavenge…”
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ATP-binding on Fibroblast Growth Factor 2 Partially Overlaps with the Heparin-binding Domain by Rose, Karsten, Pallast, Stefanie, Klumpp, Susanne, Krieglstein, Josef

“…Fibroblast growth factor 2 (FGF2), an intensively studied heparin-binding cytokine, is an important modulator of cell growth and differentiation under both…”
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Mitochondrial distribution of neuroglobin and its response to oxygen–glucose deprivation in primary-cultured mouse cortical neurons by Yu, Z, Xu, J, Liu, N, Wang, Y, Li, X, Pallast, S, van Leyen, K, Wang, X

“…Highlights ► We showed that neuroglobin (Ngb) is localized in mitochondria in primary neurons. ► Ngb’s mitochondrial localization is increased after OGD. ► Ngb…”
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Following experimental stroke, the recovering brain is vulnerable to lipoxygenase‐dependent semaphorin signaling by Pekcec, Anton, Yigitkanli, Kazim, Jung, Joo Eun, Pallast, Stefanie, Xing, Changhong, Antipenko, Alexander, Minchenko, Maria, Nikolov, Dimitar B., Holman, Theodore R., Lo, Eng H., Leyen, Klaus

“…Recovery from stroke is limited, in part, by an inhibitory environment in the postischemic brain, but factors preventing successful remodeling are not well…”
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Detection of ATP-Binding to Growth Factors by König, Simone, Hasche, Anja, Pallast, Stefanie, Krieglstein, Josef, Klumpp, Susanne

“…It was shown in previous work that the interaction of growth factors (GFs) with adenosine triphosphate (ATP) is essential for their neuroprotective effect…”
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Abstract 3494: LOXblock-1 Provides Efficient, Specific, And Long-lasting Neuroprotection Against Transient Focal Ischemia In Mice By Inhibiting 12/15-Lipoxygenase by Yigitkanli, Kazim, Pekcec, Anton, Pallast, Stefanie, Mandeville, Emiri, Joshi, Netra, Smirnova, Natalya, Gazaryan, Irina G, Ratan, Rajiv R, Witztum, Joseph L, Holman, Theodore R, Lo, Eng H, Van Leyen, Klaus

“…Abstract only Background and Purpose - Acute phase stroke treatment options are currently very limited. We have previously demonstrated 12/15-lipoxygenase…”
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Basic fibroblast growth factor: Lysine 134 is essential for its neuroprotective activity by Rose, Karsten, Kriha, Dorothee, Pallast, Stefanie, Junker, Vera, Klumpp, Susanne, Krieglstein, Josef

“…Basic fibroblast growth factor (bFGF) is a heparin-binding growth factor known to cause cell proliferation, angiogenesis and neuroprotection. We have performed…”
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Phosphorylation of the growth factors bFGF, NGF and BDNF: A prerequisite for their biological activity by Klumpp, Susanne, Kriha, Dorothee, Bechmann, Gunther, Maaßen, Alexander, Maier, Sandra, Pallast, Stefanie, Hoell, Patrick, Krieglstein, Josef

“…The aim of this work was to test whether growth factors such as basic fibroblast growth factor (bFGF), nerve growth factor (NGF) and brain-derived neurotrophic…”
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