Search Results - "PALAZON, Asis"

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape by Rodriguez-Garcia, Alba, Palazon, Asis, Noguera-Ortega, Estela, Powell, Jr, Daniel J, Guedan, Sonia

“…Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients…”
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HIF Transcription Factors, Inflammation, and Immunity by Palazon, Asis, Goldrath, Ananda W., Nizet, Victor, Johnson, Randall S.

“…The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF) transcription factors; these play an integral role in the…”
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Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b by Lenza, Maria Pia, Egia-Mendikute, Leire, Antoñana-Vildosola, Asier, Soares, Cátia O., Coelho, Helena, Corzana, Francisco, Bosch, Alexandre, Manisha, Prodhi, Quintana, Jon Imanol, Oyenarte, Iker, Unione, Luca, Moure, María Jesús, Azkargorta, Mikel, Atxabal, Unai, Sobczak, Klaudia, Elortza, Felix, Sutherland, James D., Barrio, Rosa, Marcelo, Filipa, Jiménez-Barbero, Jesús, Palazon, Asis, Ereño-Orbea, June

“…Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging cancer immunotherapy target. However, limited understanding of its…”
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Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment by Prieto-Fernández, Endika, Egia-Mendikute, Leire, Bosch, Alexandre, García Del Río, Ana, Jimenez-Lasheras, Borja, Antoñana-Vildosola, Asier, Lee, So Young, Palazon, Asis

“…The syndecan (Sdc) family is comprised of four members of cell surface molecules (Sdc-1 to 4) with different biological functions. Syndecan-3 (Sdc-3) is known…”
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SimB16: modeling induced immune system response against B16-melanoma by Pappalardo, Francesco, Martinez Forero, Ivan, Pennisi, Marzio, Palazon, Asis, Melero, Ignacio, Motta, Santo

“…Immunological therapy of progressive tumors requires not only activation and expansion of tumor specific cytotoxic T lymphocytes (CTLs), but also an efficient…”
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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function by Foskolou, Iosifina P., Cunha, Pedro P., Sánchez-López, Elena, Minogue, Eleanor A., Nicolet, Benoît P., Guislain, Aurélie, Jorgensen, Christian, Kostidis, Sarantos, Zandhuis, Nordin D., Barbieri, Laura, Bargiela, David, Nathanael, Demitris, Tyrakis, Petros A., Palazon, Asis, Giera, Martin, Wolkers, Monika C., Johnson, Randall S.

“…2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in…”
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Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods by Stagnoli, Soledad, Peccati, Francesca, Connell, Sean R, Martinez-Castillo, Ane, Charro, Diego, Millet, Oscar, Bruzzone, Chiara, Palazon, Asis, Ardá, Ana, Jiménez-Barbero, Jesús, Ereño-Orbea, June, Abrescia, Nicola G A, Jiménez-Osés, Gonzalo

“…Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains…”
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A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity by Nelson, Nadine, Lopez-Pelaez, Marta, Palazon, Asis, Poon, Edmund, De La Roche, Maike, Barry, Simon, Valge-Archer, Viia, Wilkinson, Robert W., Dovedi, Simon J., Smith, Paul D.

“…In vitro assays that evaluate CD8 + T cell-mediated cytotoxicity are important to aid in the development of novel therapeutic approaches to enhance anti-tumor…”
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Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate by Prieto-Fernández, Endika, Egia-Mendikute, Leire, Vila-Vecilla, Laura, Bosch, Alexandre, Barreira-Manrique, Adrián, Lee, So Young, García-del Río, Ana, Antoñana-Vildosola, Asier, Jiménez-Lasheras, Borja, Moreno-Cugnon, Leire, Jiménez-Barbero, Jesús, Berra, Edurne, Ereño-Orbea, June, Palazon, Asis

“…A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and…”
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Lysine 63 Polyubiquitination in Immunotherapy and in Cancer-promoting Inflammation by Martinez-Forero, Ivan, Rouzaut, Ana, Palazon, Asis, Dubrot, Juan, Melero, Ignacio

“…Covalent and reversible post-translational modifications of proteins are a common theme in signaling. Ubiquitin conjugation was originally described to target…”
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The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes by Mercado-Gómez, Maria, Prieto-Fernández, Endika, Goikoetxea-Usandizaga, Naroa, Vila-Vecilla, Laura, Azkargorta, Mikel, Bravo, Miren, Serrano-Maciá, Marina, Egia-Mendikute, Leire, Rodríguez-Agudo, Rubén, Lachiondo-Ortega, Sofia, Lee, So Young, Eguileor Giné, Alvaro, Gil-Pitarch, Clàudia, González-Recio, Irene, Simón, Jorge, Petrov, Petar, Jover, Ramiro, Martínez-Cruz, Luis Alfonso, Ereño-Orbea, June, Delgado, Teresa Cardoso, Elortza, Felix, Jiménez-Barbero, Jesús, Nogueiras, Ruben, Prevot, Vincent, Palazon, Asis, Martínez-Chantar, María L.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a multi-organ damage that includes hepatic dysfunction, which has been observed in over 50%…”
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Factor-inhibiting HIF (FIH) promotes lung cancer progression by García-del Río, Ana, Prieto-Fernández, Endika, Egia-Mendikute, Leire, Antoñana-Vildosola, Asier, Jimenez-Lasheras, Borja, Lee, So Young, Barreira-Manrique, Adrián, Zanetti, Samanta Romina, de Blas, Ander, Velasco-Beltrán, Paloma, Bosch, Alexandre, Aransay, Ana M., Palazon, Asis

“…Factor inhibiting HIF (FIH) is an asparagine hydroxylase that acts on hypoxia inducible factors (HIFs) to control cellular adaptation to hypoxia. FIH is…”
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Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis by Evans, Colin E, Palazon, Asis, Sim, Jingwei, Tyrakis, Petros A, Prodger, Alice, Lu, Xiao, Chan, Saria, Bendahl, Pär-Ola, Belting, Mattias, Von Euler, Love, Rundqvist, Helene, Johnson, Randall S, Branco, Cristina

“…Thrombosis can cause localized ischemia and tissue hypoxia, and both of these are linked to cancer metastasis. Vascular micro-occlusion can occur as a result…”
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Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes by Alfaro, Carlos, Suarez, Natalia, Oñate, Carmen, Perez-Gracia, Jose L, Martinez-Forero, Ivan, Hervas-Stubbs, Sandra, Rodriguez, Inmaculada, Perez, Guiomar, Bolaños, Elixabet, Palazon, Asis, Sanmamed, Miguel Fernandez de, Morales-Kastresana, Aizea, Gonzalez, Alvaro, Melero, Ignacio

“…Dendritic cells (DC) are endowed with the ability to cross-present antigens from other cell types to cognate T cells. DC are poised to meet polymorphonuclear…”
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Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy by Ochoa, Maria C, Fioravanti, Jessica, Duitman, Erwin H, Medina-Echeverz, Jose, Palazon, Asis, Arina, Ainhoa, Dubrot, Juan, Alfaro, Carlos, Morales-Kastresana, Aizea, Murillo, Oihana, Hervas-Stubbs, Sandra, Prieto, Jesus, Berraondo, Pedro, Melero, Ignacio

“…Apolipoprotein A-I (Apo A-I) is a major component of high density lipoproteins (HDL) that transport cholesterol in circulation. We have constructed an…”
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Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer by PALAZON, Asis, ARAGONES, Julián, MORALES-KASTRESANA, Aizea, DE LANDAZURI, Manuel Ortiz, MELERO, Ignacio

“…Both malignant and stromal components in tumors are influenced by the physiologic conditions of the microenvironment. Hypoxia is a prominent feature of solid…”
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Immune Response Regulation in the Tumor Microenvironment by Hypoxia by Labiano, Sara, Palazon, Asis, Melero, Ignacio

“…Lymphocytes and myeloid cells sense hypoxia by the hypoxia-inducible factor (HIF) transcriptional system and via other molecular mechanisms. Low O2…”
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An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression by Palazon, Asis, Tyrakis, Petros A., Macias, David, Veliça, Pedro, Rundqvist, Helene, Fitzpatrick, Susan, Vojnovic, Nikola, Phan, Anthony T., Loman, Niklas, Hedenfalk, Ingrid, Hatschek, Thomas, Lövrot, John, Foukakis, Theodoros, Goldrath, Ananda W., Bergh, Jonas, Johnson, Randall S.

“…Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion…”
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Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism by Labiano, Sara, Palazón, Asis, Bolaños, Elixabet, Azpilikueta, Arantza, Sánchez-Paulete, Alfonso R., Morales-Kastresana, Aizea, Quetglas, Jose I., Perez-Gracia, José L., Gúrpide, Alfonso, Rodriguez-Ruiz, Maria, Aznar, M. Angela, Jure-Kunkel, Maria, Berraondo, Pedro, Melero, Ignacio

“…Hypoxia is a common feature in solid tumors that has been implicated in immune evasion. Previous studies from our group have shown that hypoxia upregulates the…”
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Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination by Melero, Ignacio, Martinez-Forero, Ivan, Dubrot, Juan, Suarez, Natalia, Palazón, Asis, Chen, Lieping

“…Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering…”
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