Search Results - "PAK, E"

Efficient evolution of human antibodies from general protein language models by Hie, Brian L., Shanker, Varun R., Xu, Duo, Bruun, Theodora U. J., Weidenbacher, Payton A., Tang, Shaogeng, Wu, Wesley, Pak, John E., Kim, Peter S.

“…Natural evolution must explore a vast landscape of possible sequences for desirable yet rare mutations, suggesting that learning from natural evolutionary…”
Get full text

AIRRscape: An interactive tool for exploring B-cell receptor repertoires and antibody responses by Waltari, Eric, Nafees, Saba, McCutcheon, Krista M, Wong, Joan, Pak, John E

“…The sequencing of antibody repertoires of B-cells at increasing coverage and depth has led to the identification of vast numbers of immunoglobulin heavy and…”
Get full text

Structures suggest a mechanism for energy coupling by a family of organic anion transporters by Leano, Jonathan B, Batarni, Samir, Eriksen, Jacob, Juge, Narinobu, Pak, John E, Kimura-Someya, Tomomi, Robles-Colmenares, Yaneth, Moriyama, Yoshinori, Stroud, Robert M, Edwards, Robert H

“…Members of the solute carrier 17 (SLC17) family use divergent mechanisms to concentrate organic anions. Membrane potential drives uptake of the principal…”
Get full text

Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1 by Li, Zhijie, Han, Kristina, Pak, John E, Satkunarajah, Malathy, Zhou, Dongxia, Rini, James M

“…X-ray crystallographic analysis of the mouse protein- O -fucosyltransferase POFUT1 combined with average structural map analysis demonstrate that POFUT1…”
Get full text

A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV‑2 in Mice by Powell, Abigail E, Zhang, Kaiming, Sanyal, Mrinmoy, Tang, Shaogeng, Weidenbacher, Payton A, Li, Shanshan, Pham, Tho D, Pak, John E, Chiu, Wah, Kim, Peter S

“…The development of a safe and effective SARS-CoV-2 vaccine is a public health priority. We designed subunit vaccine candidates using self-assembling ferritin…”
Get full text

Open-source milligram-scale, four channel, automated protein purification system by Puccinelli, Robert R, Sama, Samia S, Worthington, Caroline M, Puschnik, Andreas S, Pak, John E, Gómez-Sjöberg, Rafael

“…Liquid chromatography purification of multiple recombinant proteins, in parallel, could catalyze research and discovery if the processes are fast and approach…”
Get full text

Hohlraum Reheating from Burning NIF Implosions by Rubery, M S, Rosen, M D, Aybar, N, Landen, O L, Divol, L, Young, C V, Weber, C, Hammer, J, Moody, J D, Moore, A S, Kritcher, A L, Zylstra, A B, Hurricane, O, Pak, A E, MacLaren, S, Zimmerman, G, Harte, J, Woods, T

“…As fusion experiments at the National Ignition Facility (NIF) approach and exceed breakeven, energy from the burning capsule is predicted to couple to the gold…”
Get full text

MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern by Wu, D, Raafat, M, Pak, E, Hammond, S, Murashov, A.K

“…Abstract Recently, functional and potent RNA interference (RNAi) has been reported in peripheral nerve axons transfected with short-interfering RNA (siRNA). In…”
Get full text

Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics by Durham, Natasha D, Agrawal, Aditi, Waltari, Eric, Croote, Derek, Zanini, Fabio, Fouch, Mallorie, Davidson, Edgar, Smith, Olivia, Carabajal, Esteban, Pak, John E, Doranz, Benjamin J, Robinson, Makeda, Sanz, Ana M, Albornoz, Ludwig L, Rosso, Fernando, Einav, Shirit, Quake, Stephen R, McCutcheon, Krista M, Goo, Leslie

“…Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important…”
Get full text

Development of Improved Radiation Drive Environment for High Foot Implosions at the National Ignition Facility by Hinkel, D E, Berzak Hopkins, L F, Ma, T, Ralph, J E, Albert, F, Benedetti, L R, Celliers, P M, Döppner, T, Goyon, C S, Izumi, N, Jarrott, L C, Khan, S F, Kline, J L, Kritcher, A L, Kyrala, G A, Nagel, S R, Pak, A E, Patel, P, Rosen, M D, Rygg, J R, Schneider, M B, Turnbull, D P, Yeamans, C B, Callahan, D A, Hurricane, O A

“…Analyses of high foot implosions show that performance is limited by the radiation drive environment, i.e., the hohlraum. Reported here are significant…”
Get full text

Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records by Routledge, Isobel, Epstein, Adrienne, Takahashi, Saki, Janson, Owen, Hakim, Jill, Duarte, Elias, Turcios, Keirstinne, Vinden, Joanna, Sujishi, Kirk, Rangel, Jesus, Coh, Marcelina, Besana, Lee, Ho, Wai-Kit, Oon, Ching-Ying, Ong, Chui Mei, Yun, Cassandra, Lynch, Kara, Wu, Alan H. B., Wu, Wesley, Karlon, William, Thornborrow, Edward, Peluso, Michael J., Henrich, Timothy J., Pak, John E., Briggs, Jessica, Greenhouse, Bryan, Rodriguez-Barraquer, Isabel

“…Serosurveillance provides a unique opportunity to quantify the proportion of the population that has been exposed to pathogens. Here, we developed and piloted…”
Get full text

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome by Collins, Francis S, Eriksson, Maria, Brown, W. Ted, Gordon, Leslie B, Glynn, Michael W, Singer, Joel, Scott, Laura, Erdos, Michael R, Robbins, Christiane M, Moses, Tracy Y, Berglund, Peter, Dutra, Amalia, Pak, Evgenia, Durkin, Sandra, Csoka, Antonei B, Boehnke, Michael, Glover, Thomas W

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by features reminiscent of marked premature ageing. Here, we present…”
Get full text

Myelodysplasia in autosomal dominant and sporadic monocytopenia immunodeficiency syndrome: diagnostic features and clinical implications by CALVO, Katherine R, VINH, Donald C, MYUNG, Kyungjae, HSU, Amy P, HICKSTEIN, Dennis D, PITTALUGA, Stefania, HOLLAND, Steven M, MARIC, Irina, WEIXIN WANG, NOEL, Pierre, STETLER-STEVENSON, Maryalice, ARTHUR, Diane C, RAFFELD, Mark, DUTRA, Amalia, PAK, Evgenia

“…A novel, genetic immunodeficiency syndrome has been recently described, herein termed "MonoMAC". It is characterized by severe circulating monocytopenia, NK-…”
Get full text

Surgical treatment of retroperitoneal neuroblastoma in children. Clinical experience by Kuznetsov, S. A., Kolesnikov, E. N., Shevchenko, A. N., Kozel, Yu. Yu, Mkrtchyan, G. A., Starzhetskaya, M. V., Bespalova, A. I., Pak, E. E., Yurchenko, D. Yu, Popovyan, O. P.

“…Purpose of the study. Was to analyze our experience of surgical treatment of retroperitoneal neuroblastoma in children and the influence of radical surgical…”
Get full text

Rapid identification of bloodstream infection pathogens by Panova, N.I., Kit, O.I., Kutsevalova, O.Y., Lysenko, I.B., Dmitrieva, V.V., Rozenko, D.A., Gevorkyan, Y.A., Pak, E.E., Kozyuk, O.V., Kapuza, E.A., Shatokhina, O.N., Nikolaeva, N.V., Kalabanova, E.A., Mitashok, I.S., Vladimirova, L.Y.

Get full text

SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay by Peluso, Michael J, Takahashi, Saki, Hakim, Jill, Kelly, J Daniel, Torres, Leonel, Iyer, Nikita S, Turcios, Keirstinne, Janson, Owen, Munter, Sadie E, Thanh, Cassandra, Donatelli, Joanna, Nixon, Christopher C, Hoh, Rebecca, Tai, Viva, Fehrman, Emily A, Hernandez, Yanel, Spinelli, Matthew A, Gandhi, Monica, Palafox, Mary-Ann, Vallari, Ana, Rodgers, Mary A, Prostko, John, Hackett, Jr, John, Trinh, Lan, Wrin, Terri, Petropoulos, Christos J, Chiu, Charles Y, Norris, Philip J, DiGermanio, Clara, Stone, Mars, Busch, Michael P, Elledge, Susanna K, Zhou, Xin X, Wells, James A, Shu, Albert, Kurtz, Theodore W, Pak, John E, Wu, Wesley, Burbelo, Peter D, Cohen, Jeffrey I, Rutishauser, Rachel L, Martin, Jeffrey N, Deeks, Steven G, Henrich, Timothy J, Rodriguez-Barraquer, Isabel, Greenhouse, Bryan

“…Interpretation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurveillance studies is limited by poorly defined performance of antibody…”
Get full text

Rapid SARS-CoV‑2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors by Pinals, Rebecca L, Ledesma, Francis, Yang, Darwin, Navarro, Nicole, Jeong, Sanghwa, Pak, John E, Kuo, Lili, Chuang, Yung-Chun, Cheng, Yu-Wei, Sun, Hung-Yu, Landry, Markita P

“…To effectively track and eliminate COVID-19, it is critical to develop tools for rapid and accessible diagnosis of actively infected individuals. Here, we…”
Get full text

Convergent antibody responses to SARS-CoV-2 in convalescent individuals by Robbiani, Davide F., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. C., Wang, Zijun, Cho, Alice, Agudelo, Marianna, Barnes, Christopher O., Gazumyan, Anna, Finkin, Shlomo, Hägglöf, Thomas, Oliveira, Thiago Y., Viant, Charlotte, Hurley, Arlene, Hoffmann, Hans-Heinrich, Millard, Katrina G., Kost, Rhonda G., Cipolla, Melissa, Gordon, Kristie, Bianchini, Filippo, Chen, Spencer T., Ramos, Victor, Patel, Roshni, Dizon, Juan, Shimeliovich, Irina, Mendoza, Pilar, Hartweger, Harald, Nogueira, Lilian, Pack, Maggi, Horowitz, Jill, Schmidt, Fabian, Weisblum, Yiska, Michailidis, Eleftherios, Ashbrook, Alison W., Waltari, Eric, Pak, John E., Huey-Tubman, Kathryn E., Koranda, Nicholas, Hoffman, Pauline R., West, Anthony P., Rice, Charles M., Hatziioannou, Theodora, Bjorkman, Pamela J., Bieniasz, Paul D., Caskey, Marina, Nussenzweig, Michel C.

“…During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of…”
Get full text

Transplantation of GABAergic neurons but not astrocytes induces recovery of sensorimotor function in the traumatically injured brain by Becerra, G.D., Tatko, L.M., Pak, E.S., Murashov, A.K., Hoane, M.R.

“…Embryonic stem (ES) cells have been investigated in many animal models of injury and disease. However, few studies have examined the ability of…”
Get full text

Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity by Dutra, A, Pak, E, Wincovitch, S, John, K, Poirier, M C, Olivero, O A

“…Normal diploid somatic mammalian cell division generates 2 daughter cells as a result of a strict and well-controlled mitotic process. However, some defects…”
Get more information