Search Results - "PAK, B. J"

Tyrosinase-related protein 2 as a mediator of melanoma specific resistance to cis-diamminedichloroplatinum(II) : therapeutic implications by CHU, W, PAK, B. J, BANI, M. R, KAPOOR, M, LU, S.-J, TAMIR, A, KERBEL, R. S, BEN-DAVID, Y

“…A major obstacle in the systemic treatment of advanced malignant melanoma is its intrinsic resistance to conventionally used chemotherapeutic agents. In order…”
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Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition by IQBAL, Shehzad M, BALL, Terry B, KAUL, Rupert, PLUMMER, Francis A, LEVINSON, Pauline, MARANAN, Lillian, JAOKO, Walter, WACHIHI, Charles, PAK, Brian J, PODUST, Vladimir N, BROLIDEN, Kristina, HIRBOD, Taha

“…Globally, heterosexual intercourse is the primary route of HIV-1 (HIV) transmission. It follows that mechanisms that protect against HIV infection are likely…”
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p45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemias by Li, Y J, Higgins, R R, Pak, B J, Shivdasani, R A, Ney, P A, Archer, M, Ben-David, Y

“…In previous studies, we identified a common site of retroviral integration designated Fli-2 in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia…”
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TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content by Pak, B J, Li, Q, Kerbel, R S, Ben-David, Y

“…Tyrosinase-related protein-2 (TYRP2) is a melanocyte-specific enzyme that catalyses the non-decarboxylative tautomerization of L-dopachrome to…”
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Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells by Pak, B.J., Park, H., Chang, E.R., Pang, S.C., Graham, C.H.

“…Physiologic or pathologically induced periods of exposure to relatively low levels of oxygen during pregnancy affect the expression and function of certain…”
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Cellular localization of gp46 at the human fetal-maternal interface by Pak, B.J., Pang, S.C., Graham, C.H.

“…gp46 is a collagen-binding heat-shock glycoprotein with a possible role in the biosynthesis of collagen as well as in cell differentiation and fusion. In this…”
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Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase by PAK, Brian J, LEE, Jane, THAI, Boun L, FUCHS, Serge Y, SHAKED, Yuval, RONAI, Zeev, KERBEL, Robert S, BEN-DAVID, Yaacov

“…While melanomas are resistant to the cytotoxic effects of radiotherapy, little is known about the molecular mechanisms underlying this intrinsic resistance…”
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Lineage-specific mechanism of drug and radiation resistance in melanoma mediated by tyrosinase-related protein 2 by Pak, B J, Chu, W, Lu, S J, Kerbel, R S, Ben-David, Y

“…A major obstacle in the clinical management of malignant melanoma is its intrinsic resistance to chemotherapy and radiation therapy. Consequently, most…”
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Developmental Regulation of the Translational Repressor NAT1 During Cardiac Development by Pak, Brian J, Pang, Stephen C

“…The process of translation initiation has been postulated to play an important role in the regulation of cellular growth and proliferation. Here, we report the…”
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Molecular cloning and developmental expression of rat glycogenin in cardiac tissue by Pak, B J, Sangaralingham, S J, Pang, S C

“…Glycogenin is a self-glycosylating protein required to initiate glycogen biosynthesis. Utilizing the differential display technique to analyze changes in gene…”
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Developmental expression of the collagen-binding heat-shock protein GP46 and collagen types I and IV in rat tissues by Pak, B J, Wigle, D A, Watson, J D, Cates, G A, Brickenden, A M, Ball, E H, Pang, S C

“…The temporal expression of protein and mRNA encoding the collagen-binding heat-shock glycoprotein, gp46, were determined in the heart, kidney, and lung during…”
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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane by Pasternak, Stephen H., Bagshaw, Richard D., Guiral, Marianne, Zhang, Sunqu, Ackerley, Cameron A., Pak, Brian J., Callahan, John W., Mahuran, Don J.

“…Alzheimer's disease (AD) is caused by the cerebral deposition of β-amyloid (Aβ), a 38–43-amino acid peptide derived by proteolytic cleavage of the amyloid…”
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Tissue distribution and immunohistochemical localization of the collagen-binding heat-shock protein gp46 in neonatal rats by Pak, B J, Vanhorne, J B, Pang, S C

“…Collagen-binding heat-shock proteins of M(r) 46-47 kDa have been postulated to function as putative molecular chaperones in the biosynthesis of collagen in…”
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p45 super(NFE2) Is a Negative Regulator of Erythroid Proliferation Which Contributes to the Progression of Friend Virus-Induced Erythroleukemias by Li, Y, Higgins, R R, Pak, B J, Shivdasani, R A, Ney, P A, Archer, M, David, Y B

“…In previous studies, we identified a common site of retroviral integration designated Fli-2 in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia…”
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The splenic microenvironment is a source of proangiogenesis/inflammatory mediators accelerating the expansion of murine erythroleukemic cells by Shaked, Yuval, Cervi, Dave, Neuman, Manuela, Chen, Limor, Klement, Giannoula, Michaud, Crystal R., Haeri, Mehran, Pak, Brian J., Kerbel, Robert S., Ben-David, Yaacov

“…The stromal compartments of hematopoietic organs (eg, spleen) are known to influence the viability and growth of diseased hematopoietic progenitors. Here we…”
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Contiguous arrangement of p45 NFE2, HnRNP A1, and HP1α on mouse chromosome 15 and human chromosome 12: Evidence for suppression of these genes due to retroviral integration within the Fli-2 locus by Li, You-Jun, Pak, Brian J., Higgins, Rachel R., Lu, Shi-Jiang, Ben-David, Yaacov

“…Fli‐2 is a common site of proviral integration in multistage erythroleukemia cells induced by Friend murine leukemia virus (F‐MuLV) or the polycythemia strain…”
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Expression of the translational repressor NAT1 in experimental models of cardiac hypertrophy by Sangaralingham, S Jeson, Pak, Brian J, Tse, M Yat, Angelis, Ekaterini, Adams, Michael A, Smallegange, C, Pang, Stephen C

“…The development of hypertension-induced cardiac hypertrophy is a complex process involving a number of biochemical pathways. In particular, the translation…”
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