Search Results - "PAJUSOLA, KATRI"

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels by YULONG HE, RAJANTIE, Iiro, PAJUSOLA, Katri, JELTSCH, Michael, HOLOPAINEN, Tanja, YLA-HERTTUALA, Seppo, HARDING, Thomas, JOOSS, Karin, TAKAHASHI, Takashi, ALITALO, Kari

“…Lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to promote lymphatic metastasis by inducing…”
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Angiopoietin-1 promotes lymphatic sprouting and hyperplasia by Tammela, Tuomas, Saaristo, Anne, Lohela, Marja, Morisada, Tohru, Tornberg, Jenny, Norrmén, Camilla, Oike, Yuichi, Pajusola, Katri, Thurston, Gavin, Suda, Toshio, Yla-Herttuala, Seppo, Alitalo, Kari

“…Angiopoietin 1 (Ang1), a ligand for the receptor tyrosine kinase Tie2, regulates the formation and stabilization of the blood vessel network during…”
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A Model for Gene Therapy of Human Hereditary Lymphedema by Karkkainen, Marika J., Saaristo, Anne, Jussila, Lotta, Karila, Kaisa A., Lawrence, Elizabeth C., Pajusola, Katri, Bueler, Hansruedi, Eichmann, Anne, Kauppinen, Risto, Kettunen, Mikko I., Ylä-Herttuala, Seppo, Finegold, David N., Ferrell, Robert E., Alitalo, Kari

“…Primary human lymphedema (Milroy's disease), characterized by a chronic and disfiguring swelling of the extremities, is associated with heterozygous…”
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Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3 by Dumont, Daniel J., Jussila, Lotta, Taipale, Jussi, Lymboussaki, Athina, Mustonen, Tuija, Pajusola, Katri, Breitman, Martin, Alitalo, Kari

“…Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related…”
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PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis by Uutela, Marko, Wirzenius, Maria, Paavonen, Karri, Rajantie, Iiro, He, Yulong, Karpanen, Terhi, Lohela, Marja, Wiig, Helge, Salven, Petri, Pajusola, Katri, Eriksson, Ulf, Alitalo, Kari

“…Platelet-derived growth factor-D (PDGF-D) is a recently characterized member of the PDGF family with unknown in vivo functions. We investigated the effects of…”
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Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction by Sulg, Marilin, Kirjavainen, Anna, Pajusola, Katri, Bueler, Hansruedi, Ylikoski, Jukka, Laiho, Marikki, Pirvola, Ulla

“…J. Neurochem. (2010) 112, 1513-1526. Previous studies have shown that the maintenance of post-mitotic state is critical for the life-long survival of the inner…”
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Cell-Type-Specific Characteristics Modulate the Transduction Efficiency of Adeno-Associated Virus Type 2 and Restrain Infection of Endothelial Cells by Pajusola, Katri, Gruchala, Marcin, Joch, Hana, Lüscher, Thomas F, Ylä-Herttuala, Seppo, Büeler, Hansruedi

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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VEGFR3 gene structure, regulatory region, and sequence polymorphisms by Iljin, K, Karkkainen, M J, Lawrence, E C, Kimak, M A, Uutela, M, Taipale, J, Pajusola, K, Alhonen, L, Halmekytö, M, Finegold, D N, Ferrell, R E, Alitalo, K

“…Vascular endothelial growth factor receptor 3 (VEGFR-3) is required for cardiovascular development during embryogenesis. In adults, this receptor is expressed…”
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Cardiomyocyte-targeted HIF-1α gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat by Keränen, Mikko A.I., MD, Nykänen, Antti I., MD, PhD, Krebs, Rainer, MSc, Pajusola, Katri, PhD, Tuuminen, Raimo, MD, Alitalo, Kari, MD, PhD, Lemström, Karl B., MD, PhD

“…Background Hypoxia-inducible factor-1 (HIF-1), a key transcription factor in hypoxia, affects a wide range of adaptive cell functions. We examined the kinetics…”
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Common Protective and Diverse Smooth Muscle Cell Effects of AAV-Mediated Angiopoietin-1 and -2 Expression in Rat Cardiac Allograft Vasculopathy by Nykänen, Antti I, Pajusola, Katri, Krebs, Rainer, Keränen, Mikko A.I, Raisky, Olivier, Koskinen, Petri K, Alitalo, Kari, Lemström, Karl B

“…Angiopoietin-1 (Ang1) and Ang2 regulate the maintenance of normal vasculature by direct endothelial and indirect smooth muscle cell (SMC) effects. Dysfunction…”
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Genomic Organization of the Mouse and Human Genes for Vascular Endothelial Growth Factor B (VEGF-B) and Characterization of a Second Splice Isoform by Olofsson, B, Pajusola, K, von Euler, G, Chilov, D, Alitalo, K, Eriksson, U

“…A second isoform and the genomic structures of mouse and human vascular endothelial growth factor B are described. Both genes consist of seven coding exons and…”
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Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice by Jalkanen, Johanna, Leppänen, Pia, Pajusola, Katri, Närvänen, Outi, Mähönen, Anssi, Vähäkangas, Elisa, Greaves, David R, Büeler, Hansruedi, Ylä-Herttuala, Seppo

“…Macrophage scavenger receptors (MSR) promote atherosclerotic lesion formation, and modulation of MSR activity has been shown to influence atherosclerosis…”
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Stabilized HIF‐1α is superior to VEGF for angiogenesis in skeletal muscle via adeno‐associated virus gene transfer by Pajusola, Katri, Künnapuu, Jaana, Vuorikoski, Sanna, Soronen, Jarkko, André, Helder, Pereira, Teresa, Korpisalo, Petra, Ylä‐Herttuala, Seppo, Poellinger, Lorenz, Alitalo, Kari

“…ABSTRACTTherapeutic angiogenesis provides a potential alternative for the treatment of cardiovascular ischemic diseases. Vascular endothelial growth factor…”
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PDGF-A, -C, and -D but not PDGF-B Increase TGF-β1 and Chronic Rejection in Rat Cardiac Allografts by TUUMINEN, Raimo, NYKÄNEN, Antti I, KREBS, Rainer, SORONEN, Jarkko, PAJUSOLA, Katri, KERÄNEN, Mikko A. I, KOSKINEN, Petri K, ALITALO, Kari, LEMSTRÖM, Karl B

“…Objective— Chronic rejection is the main reason for the poor long-term survival of heart transplant recipients and is characterized by cardiac allograft…”
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A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases by Joukov, V., Pajusola, K., Kaipainen, A., Chilov, D., Lahtinen, I., Kukk, E., Saksela, O., Kalkkinen, N., Alitalo, K.

“…Angiogenesis, the sprouting of new blood vessels from pre‐existing ones, and the permeability of blood vessels are regulated by vascular endothelial growth…”
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Lymphangiogenic gene therapy with minimal blood vascular side effects by Saaristo, Anne, Veikkola, Tanja, Tammela, Tuomas, Enholm, Berndt, Karkkainen, Marika J, Pajusola, Katri, Bueler, Hansruedi, Ylä-Herttuala, Seppo, Alitalo, Kari

“…Recent work from many laboratories has demonstrated that the vascular endothelial growth factor-C/VEGF-D/VEGFR-3 signaling pathway is crucial for…”
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Vascular Endothelial Growth Factor B, a Novel Growth Factor for Endothelial Cells by Olofsson, Birgitta, Pajusola, Katri, Kaipainen, Arja, Von Euler, Gabriel, Joukov, Vladimir, Saksela, Olli, Orpana, Arto, Pettersson, Ralf F., Alitalo, Kari, Eriksson, Ulf

“…We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to…”
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Adenoviral VEGF‐C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes by SAARISTO, ANNE, VEIKKOLA, TANJA, ENHOLM, BERNDT, HYTÖNEN, MAIJA, AROLA, JOHANNA, PAJUSOLA, KATRI, TURUNEN, PAIVI, JELTSCH, MICHAEL, KARKKAINEN, MARIKA J., KERJASCHKI, DONTSCHO, BUELER, HANSRUEDI, YLA‐HERTTUALA, SEPPO, ALITALO, KARI

“…ABSTRACT Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are important regulators of blood and lymphatic vessel growth and vascular…”
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Distinct Architecture of Lymphatic Vessels Induced by Chimeric Vascular Endothelial Growth Factor-C/Vascular Endothelial Growth Factor Heparin-Binding Domain Fusion Proteins by Tammela, Tuomas, He, Yulong, Lyytikkä, Johannes, Jeltsch, Michael, Markkanen, Johanna, Pajusola, Katri, Ylä-Herttuala, Seppo, Alitalo, Kari

“…Vascular endothelial growth factor (VEGF)-C and VEGF-D are composed of the receptor-binding VEGF homology domain and a carboxy-terminal silk homology domain…”
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Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants by Raissadati, Alireza, Jokinen, Janne J, Syrjälä, Simo O, Keränen, Mikko A I, Krebs, Rainer, Tuuminen, Raimo, Arnaudova, Ralica, Rouvinen, Eeva, Anisimov, Andrey, Soronen, Jarkko, Pajusola, Katri, Alitalo, Kari, Nykänen, Antti I, Lemström, Karl

“…Heart transplant gene therapy requires vectors with long-lasting gene expression, high cardiotropism, and minimal pathological effects. Here, we examined…”
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