Search Results - "PAINE, MARK"

CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae by Edi, Constant V, Djogbénou, Luc, Jenkins, Adam M, Regna, Kimberly, Muskavitch, Marc A T, Poupardin, Rodolphe, Jones, Christopher M, Essandoh, John, Kétoh, Guillaume K, Paine, Mark J I, Koudou, Benjamin G, Donnelly, Martin J, Ranson, Hilary, Weetman, David

“…Malaria control relies heavily on pyrethroid insecticides, to which susceptibility is declining in Anopheles mosquitoes. To combat pyrethroid resistance,…”
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Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector by Ibrahim, Sulaiman S, Riveron, Jacob M, Bibby, Jaclyn, Irving, Helen, Yunta, Cristina, Paine, Mark J I, Wondji, Charles S

“…Scale up of Long Lasting Insecticide Nets (LLINs) has massively contributed to reduce malaria mortality across Africa. However, resistance to pyrethroid…”
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Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana by Mitchell, Sara N, Stevenson, Bradley J, Müller, Pie, Wilding, Craig S, Egyir-Yawson, Alexander, Field, Stuart G, Hemingway, Janet, Paine, Mark J. I, Ranson, Hilary, Donnelly, Martin James

“…In the last decade there have been marked reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to…”
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Antimalarial activity of primaquine operates via a two-step biochemical relay by Camarda, Grazia, Jirawatcharadech, Piyaporn, Priestley, Richard S., Saif, Ahmed, March, Sandra, Wong, Michael H. L., Leung, Suet, Miller, Alex B., Baker, David A., Alano, Pietro, Paine, Mark J. I., Bhatia, Sangeeta N., O’Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.

“…Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70 years ago, its mode of action is unclear. Here, we demonstrate that…”
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Pinpointing P450s associated with pyrethroid metabolism in the dengue vector, Aedes aegypti: developing new tools to combat insecticide resistance by Stevenson, Bradley J, Pignatelli, Patricia, Nikou, Dimitra, Paine, Mark J I

“…Pyrethroids are increasingly used to block the transmission of diseases spread by Aedes aegypti such as dengue and yellow fever. However, insecticide…”
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Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids by Müller, Pie, Warr, Emma, Stevenson, Bradley J, Pignatelli, Patricia M, Morgan, John C, Steven, Andrew, Yawson, Alexander E, Mitchell, Sara N, Ranson, Hilary, Hemingway, Janet, Paine, Mark J I, Donnelly, Martin J

“…Insects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides…”
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High pyrethroid/DDT resistance in major malaria vector Anopheles coluzzii from Niger-Delta of Nigeria is probably driven by metabolic resistance mechanisms by Muhammad, Abdullahi, Ibrahim, Sulaiman S, Mukhtar, Muhammad M, Irving, Helen, Abajue, Maduamaka C, Edith, Noutcha M A, Da'u, Sabitu S, Paine, Mark J I, Wondji, Charles S

“…Entomological surveillance of local malaria vector populations is an important component of vector control and resistance management. In this study, the…”
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New insecticide screening platforms indicate that Mitochondrial Complex I inhibitors are susceptible to cross-resistance by mosquito P450s that metabolise pyrethroids by Lees, Rosemary S., Ismail, Hanafy M., Logan, Rhiannon A. E., Malone, David, Davies, Rachel, Anthousi, Amalia, Adolfi, Adriana, Lycett, Gareth J., Paine, Mark J. I.

“…Fenazaquin, pyridaben, tolfenpyrad and fenpyroximate are Complex I inhibitors offering a new mode of action for insecticidal malaria vector control . However,…”
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Tandem duplication of a genomic region encoding glutathione S-transferase epsilon-2 and -4 genes in DDT-resistant Anopheles stephensi strain from India by Dykes, Cherry L., Sharma, Gunjan, Behera, Abhisek K., Kapoor, Neera, Paine, Mark J. I., Donnelly, Martin J., Singh, Om P.

“…The glutathione S-transferases (GST) genes are a multigene family of enzymes involved in the metabolism of endogenous and xenobiotic compounds by catalysing…”
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Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed by Stevenson, Bradley J., Bibby, Jaclyn, Pignatelli, Patricia, Muangnoicharoen, Sant, O’Neill, Paul M., Lian, Lu-Yun, Müller, Pie, Nikou, Dimitra, Steven, Andrew, Hemingway, Janet, Sutcliffe, Michael J., Paine, Mark J.I.

“…Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes. Cytochome P450-mediated…”
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Sequential phase I metabolism of pyrethroids by duplicated CYP6P9 variants results in the loss of the terminal benzene moiety and determines resistance in the malaria mosquito Anopheles funestus by Nolden, Melanie, Paine, Mark J.I., Nauen, Ralf

“…Pyrethroid resistance in Anopheles funestus is threatening the eradication of malaria. One of the major drivers of pyrethroid resistance in An. funestus are…”
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Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae by Mitchell, Sara N, Rigden, Daniel J, Dowd, Andrew J, Lu, Fang, Wilding, Craig S, Weetman, David, Dadzie, Samuel, Jenkins, Adam M, Regna, Kimberly, Boko, Pelagie, Djogbenou, Luc, Muskavitch, Marc A T, Ranson, Hilary, Paine, Mark J I, Mayans, Olga, Donnelly, Martin J

“…The development of resistance to insecticides has become a classic exemplar of evolution occurring within human time scales. In this study we demonstrate how…”
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Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae by Yunta, Cristina, Grisales, Nelson, Nász, Szilárd, Hemmings, Kay, Pignatelli, Patricia, Voice, Michael, Ranson, Hilary, Paine, Mark J.I.

“…Pyrethroid resistance is widespread in the malaria vector Anopheles gambiae leading to concerns about the future efficacy of bednets with pyrethroids as the…”
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Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers by Yunta, Cristina, Ooi, Jocelyn M. F., Oladepo, Folasade, Grafanaki, Sofia, Pergantis, Spiros. A., Tsakireli, Dimitra, Ismail, Hanafy M., Paine, Mark J. I.

“…Chlorfenapyr is a pro-insecticide increasingly used in combination with pyrethroids such as a-cypermethrin or deltamethrin in insecticide treated bednets…”
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Cross-resistance profiles of malaria mosquito P450s associated with pyrethroid resistance against WHO insecticides by Yunta, Cristina, Hemmings, Kay, Stevenson, Bradley, Koekemoer, Lizette L., Matambo, Tonderi, Pignatelli, Patricia, Voice, Michael, Nász, Szilárd, Paine, Mark J.I.

“…Extensive use of pyrethroids for malaria control in Africa has led to widespread pyrethroid resistance in the two major African vectors of malaria An. gambiae…”
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Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus by Riveron, Jacob M., Irving, Helen, Ndula, Miranda, Barnes, Kayla G., Ibrahim, Sulaiman S., Paine, Mark J. I., Wondji, Charles S.

“…Pyrethroid insecticides are critical for malaria control in Africa. However, resistance to this insecticide class in the malaria vector Anopheles funestus is…”
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A high-throughput HPLC method for simultaneous quantification of pyrethroid and pyriproxyfen in long-lasting insecticide-treated nets by Walker, Kyle J., Williams, Christopher T., Oladepo, Folasade O., Lucas, John, Malone, David, Paine, Mark J. I., Ismail, Hanafy M.

“…Long-lasting insecticide-treated nets (LLINs) play a crucial role in preventing malaria transmission. LLINs should remain effective for at least three years,…”
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Biochemical profiling of functionally expressed CYP6P9 variants of the malaria vector Anopheles funestus with special reference to cytochrome b5 and its role in pyrethroid and coumarin substrate metabolism by Nolden, Melanie, Paine, Mark J.I., Nauen, Ralf

“…Cytochrome P450 monooxygenases (P450s) are well studied enzymes catalyzing the oxidative metabolism of xenobiotics in insects including mosquitoes. Their…”
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High concentrations of membrane-fed ivermectin are required for substantial lethal and sublethal impacts on Aedes aegypti by Hadlett, Max, Nagi, Sanjay C, Sarkar, Manas, Paine, Mark J I, Weetman, David

“…With widespread insecticide resistance in mosquito vectors, there is a pressing need to evaluate alternatives with different modes of action. Blood containing…”
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Resilience of transfluthrin to oxidative attack by duplicated CYP6P9 variants known to confer pyrethroid resistance in the major malaria mosquito Anopheles funestus by Nolden, Melanie, Velten, Robert, Paine, Mark J.I., Nauen, Ralf

“…Resistance to common pyrethroids, such as deltamethrin and permethrin is widespread in the malaria mosquito Anopheles funestus and mainly conferred by…”
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