Search Results - "PAGES, G"

GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin’s B lymphomas via NF-κB-dependent induction of HIF-1α by Chiche, J, Pommier, S, Beneteau, M, Mondragón, L, Meynet, O, Zunino, B, Mouchotte, A, Verhoeyen, E, Guyot, M, Pagès, G, Mounier, N, Imbert, V, Colosetti, P, Goncalvès, D, Marchetti, S, Brière, J, Carles, M, Thieblemont, C, Ricci, J-E

“…Deregulated expression of glycolytic enzymes contributes not only to the increased energy demands of transformed cells but also has non-glycolytic roles in…”
Get full text

Transcriptional regulation of the Vascular Endothelial Growth Factor gene: a concert of activating factors by PAGES, Gilles, POUYSSEGUR, Jacques

“…The vascular endothelial growth factor A (VEGF-A) is essential during embryonic development as inactivation of only one allele of its gene results in embryonic…”
Get full text

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity by Jager, J, Corcelle, V, Grémeaux, T, Laurent, K, Waget, A, Pagès, G, Binétruy, B, Le Marchand-Brustel, Y, Burcelin, R, Bost, F, Tanti, J. F

“…Aims/hypothesis Extracellular signal-regulated kinase (ERK) activity is increased in adipose tissue in obesity and type 2 diabetes mellitus and strong…”
Get full text

Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration by Homs, J, Ariza, L, Pagès, G, Udina, E, Navarro, X, Chillón, M, Bosch, A

“…Efficient transduction of the peripheral nervous system (PNS) is required for gene therapy of acquired and inherited neuropathies, neuromuscular diseases and…”
Get full text

Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity by Beauclair, S, Formento, P, Fischel, JL, Lescaut, W, Largillier, R, Chamorey, E, Hofman, P, Ferrero, JM, Pagès, G, Milano, G

“…Background: To examine the impact of a frequent her2 gene polymorphism (Ile655Val) on tumor growth and on the pharmacodynamics of treatment by trastuzumab…”
Get full text

Linking JNK Activity to the DNA Damage Response by Picco, Vincent, Pagès, Gilles

“…The activity of c-Jun N-terminal kinase (JNK) was initially described as ultraviolet- and oncogene-induced kinase activity on c-Jun. Shortly after this initial…”
Get full text

Overexpression of Sp1 transcription factor induces apoptosis by DENIAUD, E, BAGUET, J, MATHIEU, A.-L, PAGES, G, MARVEL, J, LEVERRIER, Y

“…Transcription factor Sp1 has recently been shown to be overexpressed in a number of human cancers and its overexpression contributes to malignant…”
Get full text

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 by Giaime, E, Sunyach, C, Druon, C, Scarzello, S, Robert, G, Grosso, S, Auberger, P, Goldberg, M S, Shen, J, Heutink, P, Pouysségur, J, Pagès, G, Checler, F, Alves da Costa, C

“…DJ-1 was recently identified as a gene product responsible for a subset of familial Parkinson's disease (PD). The mechanisms by which mutations in DJ-1 alter…”
Get full text

Effects of proton versus photon irradiation on (lymph)angiogenic, inflammatory, proliferative and anti-tumor immune responses in head and neck squamous cell carcinoma by Lupu-Plesu, M, Claren, A, Martial, S, N'Diaye, P-D, Lebrigand, K, Pons, N, Ambrosetti, D, Peyrottes, I, Feuillade, J, Hérault, J, Dufies, M, Doyen, J, Pagès, G

“…The proximity of organs at risk makes the treatment of head and neck squamous cell carcinoma (HNSCC) challenging by standard radiotherapy. The higher precision…”
Get full text

CVaR HEDGING USING QUANTIZATION-BASED STOCHASTIC APPROXIMATION ALGORITHM by Bardou, O., Frikha, N., Pagès, G.

“…In this paper, we investigate a method based on risk minimization to hedge observable but nontradable source of risk on financial or energy markets. The…”
Get full text

Experimental diabetes in neonatal mice induces early peripheral sensorimotor neuropathy by Ariza, L, Pagès, G, García-Lareu, B, Cobianchi, S, Otaegui, P.J, Ruberte, J, Chillón, M, Navarro, X, Bosch, A

“…Highlights • Experimental diabetes to neonatal mice decreases sensory nerve conduction velocity. • Neonatal type 1 diabetes reduces myelinated fibers, fiber…”
Get full text

Angiogenic/lymphangiogenic factors and adaptation to extreme altitudes during an expedition to Mount Everest by Patitucci, M, Lugrin, D, Pagès, G

“…To analyse the correlation between production of angiogenic [vascular endothelial growth factor A (VEGF-A) and interleukin 8 (IL-8)] and lymphangiogenic…”
Get full text

Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab Avastin treatment: the role of CXCL cytokines by Grepin, R, Guyot, M, Jacquin, M, Durivault, J, Chamorey, E, Sudaka, A, Serdjebi, C, Lacarelle, B, Scoazec, J-Y, Negrier, S, Simonnet, H, Pages, G

“…The anti-VEGF targeted antibody bevacizumab (BVZ) has been approved for treating renal cell carcinomas (RCCs). Although BVZ increases the progression-free…”
Get full text

UDCA slows down intestinal cell proliferation by inducing high and sustained ERK phosphorylation by Krishna-Subramanian, S., Hanski, M.L., Loddenkemper, C., Choudhary, B., Pagès, G., Zeitz, M., Hanski, C.

“…Ursodeoxycholic acid (UDCA) attenuates colon carcinogenesis in humans and in animal models by an unknown mechanism. We investigated UDCA effects on normal…”
Get full text

A study of the Roman iron bars of Saintes-Maries-de-la-Mer (Bouches-du-Rhône, France). A proposal for a comprehensive metallographic approach by Pagès, G., Dillmann, P., Fluzin, P., Long, L.

“…The aim of this paper is to contribute to the understanding of the organisation of the manufacture and circulation of iron bars and the possible bar…”
Get full text

A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma by Montemagno, Christopher, Durivault, Jérôme, Gastaldi, Cécile, Dufies, Maeva, Vial, Valérie, He, Xingkang, Ambrosetti, Damien, Kamenskaya, Anna, Negrier, Sylvie, Bernhard, Jean‐Christophe, Borchiellini, Delphine, Cao, Yihai, Pagès, Gilles

“…The efficacy of anti‐angiogenic treatment by targeting VEGF/VEGF receptors in metastatic clear cell renal cell carcinoma (ccRCC) varies from patient to…”
Get full text

The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis by BOST, Frédéric, AOUADI, Myriam, LE MARCHAND-BRUSTEL, Yannick, BINETRUY, Bernard, CARON, Leslie, EVEN, Patrick, BELMONTE, Nathalie, PROT, Matthieu, DANI, Christian, HOFMAN, Paul, PAGES, Gilles, POUYSSEGUR, Jacques

“…The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis Frédéric Bost 1 , Myriam Aouadi 1 ,…”
Get full text

A QUANTIZATION TREE METHOD FOR PRICING AND HEDGING MULTIDIMENSIONAL AMERICAN OPTIONS by Bally, Vlad, Pagès, Gilles, Printems, Jacques

“…We present here the quantization method which is well‐adapted for the pricing and hedging of American options on a basket of assets. Its purpose is to compute…”
Get full text

A quantization algorithm for solving multidimensional discrete-time optimal stopping problems by Bally, Vlad, Pagès, Gilles

“…A new grid method for computing the Snell envelope of a function of an \mathbb{R}^d-valued simulatable Markov chain (X_k)_{0\lambda \leq k\lambda \leq n} is…”
Get full text

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice by Pagès, Gilles, Guérin, Sandrine, Grall, Dominique, Bonino, Frédéric, Smith, Austin, Anjuere, Fabienne, Auberger, Patrick, Pouysségur, Jacques

“…The p42 and p44 mitogen-activated protein kinases (MAPKs), also called Erk2 and Erk1, respectively, have been implicated in proliferation as well as in…”
Get full text