Search Results - "PACKER, Roger"

Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours by Horbinski, Craig, Berger, Tamar, Packer, Roger J., Wen, Patrick Y.

“…A new edition of the WHO classification of tumours of the CNS was published in 2021. Although the previous edition of this classification was published just 5…”
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The 2021 WHO Classification of Tumors of the Central Nervous System: clinical implications by Wen, Patrick Y, Packer, Roger J

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Pediatric Brain Tumors by Udaka, Yoko T., MD, Packer, Roger J., MD

“…Pediatric central nervous system (CNS) tumors are the most common solid tumors in children and comprise 15% to 20% of all malignancies in children…”
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Optic pathway gliomas: Long-term outcomes and challenges by Packer, Roger J

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Recent Advances in Pediatric Medulloblastoma by Jackson, Kasey, Packer, Roger J

“…Purpose of Review Review recent advances in the understanding of pediatric medulloblastoma including etiology, biology, radiology, and management of pediatric…”
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Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961 by Packer, Roger J, Zhou, Tianni, Holmes, Emi, Vezina, Gilbert, Gajjar, Amar

“…The purpose of the trial was to determine the survival and incidence of secondary tumors in children with medulloblastoma receiving radiotherapy plus…”
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Molecular-Targeted Therapy for Childhood Brain Tumors: A Moving Target by Packer, Roger J., Kilburn, Lindsay

“…Molecular-targeted therapy is an attractive therapeutic approach for childhood brain tumors. Unfortunately, with some notable exceptions, such treatment has…”
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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032 by Robinson, Giles W, Orr, Brent A, Wu, Gang, Gururangan, Sridharan, Lin, Tong, Qaddoumi, Ibrahim, Packer, Roger J, Goldman, Stewart, Prados, Michael D, Desjardins, Annick, Chintagumpala, Murali, Takebe, Naoko, Kaste, Sue C, Rusch, Michael, Allen, Sariah J, Onar-Thomas, Arzu, Stewart, Clinton F, Fouladi, Maryam, Boyett, James M, Gilbertson, Richard J, Curran, Tom, Ellison, David W, Gajjar, Amar

“…Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult…”
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Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations by Bouffet, Eric, Hansford, Jordan R., Garrè, Maria Luisa, Hara, Junichi, Plant-Fox, Ashley, Aerts, Isabelle, Locatelli, Franco, van der Lugt, Jasper, Papusha, Ludmila, Sahm, Felix, Tabori, Uri, Cohen, Kenneth J., Packer, Roger J., Witt, Olaf, Sandalic, Larissa, Bento Pereira da Silva, Ana, Russo, Mark, Hargrave, Darren R.

“…The use of dabrafenib plus trametinib in pediatric low-grade glioma with BRAF V600 mutations led to longer progression-free survival and fewer grade 3 adverse…”
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Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy by Panditharatna, Eshini, Kilburn, Lindsay B, Aboian, Mariam S, Kambhampati, Madhuri, Gordish-Dressman, Heather, Magge, Suresh N, Gupta, Nalin, Myseros, John S, Hwang, Eugene I, Kline, Cassie, Crawford, John R, Warren, Katherine E, Cha, Soonmee, Liang, Winnie S, Berens, Michael E, Packer, Roger J, Resnick, Adam C, Prados, Michael, Mueller, Sabine, Nazarian, Javad

“…Pediatric diffuse midline glioma (DMG) are highly malignant tumors with poor clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M…”
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Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial by Fangusaro, Jason, Onar-Thomas, Arzu, Young Poussaint, Tina, Wu, Shengjie, Ligon, Azra H, Lindeman, Neal, Banerjee, Anuradha, Packer, Roger J, Kilburn, Lindsay B, Goldman, Stewart, Pollack, Ian F, Qaddoumi, Ibrahim, Jakacki, Regina I, Fisher, Paul G, Dhall, Girish, Baxter, Patricia, Kreissman, Susan G, Stewart, Clinton F, Jones, David T W, Pfister, Stefan M, Vezina, Gilbert, Stern, Jessica S, Panigrahy, Ashok, Patay, Zoltan, Tamrazi, Benita, Jones, Jeremy Y, Haque, Sofia S, Enterline, David S, Cha, Soonmee, Fisher, Michael J, Doyle, Laurence Austin, Smith, Malcolm, Dunkel, Ira J, Fouladi, Maryam

“…Paediatric low-grade glioma is the most common CNS tumour of childhood. Although overall survival is good, disease often recurs. No single universally accepted…”
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New treatment modalities in NF-related neuroglial tumors by Packer, Roger J., Vezina, Gilbert

“…The management of low-grade gliomas (LGGs) and other neuroglial tumors in children with neurofibromatosis type 1 (NF1) has not changed over the past 2–3…”
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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma by Nikbakht, Hamid, Panditharatna, Eshini, Mikael, Leonie G., Li, Rui, Gayden, Tenzin, Osmond, Matthew, Ho, Cheng-Ying, Kambhampati, Madhuri, Hwang, Eugene I., Faury, Damien, Siu, Alan, Papillon-Cavanagh, Simon, Bechet, Denise, Ligon, Keith L., Ellezam, Benjamin, Ingram, Wendy J., Stinson, Caedyn, Moore, Andrew S., Warren, Katherine E., Karamchandani, Jason, Packer, Roger J., Jabado, Nada, Majewski, Jacek, Nazarian, Javad

“…Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address…”
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Pediatric high-grade glioma: biologically and clinically in need of new thinking by Jones, Chris, Karajannis, Matthias A, Jones, David T W, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, Weiss, William A

“…High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed…”
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Randomized Study of Two Chemotherapy Regimens for Treatment of Low-Grade Glioma in Young Children: A Report From the Children's Oncology Group by ATER, Joann L, ZHOU, Tianni, VEZINA, Gilbert, WISOFF, Jeffrey H, POLLACK, Ian F, HOLMES, Emiko, MAZEWSKI, Claire M, BOOTH, Timothy N, FREYER, David R, LAZARUS, Ken H, PACKER, Roger J, PRADOS, Michael, SPOSTO, Richard

“…PURPOSE Surgery is curative therapy for pediatric low-grade gliomas (LGGs) in areas of the brain amenable to complete resection. However, LGGs located in areas…”
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A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study by Banerjee, Anuradha, Jakacki, Regina I, Onar-Thomas, Arzu, Wu, Shengjie, Nicolaides, Theodore, Young Poussaint, Tina, Fangusaro, Jason, Phillips, Joanna, Perry, Arie, Turner, David, Prados, Michael, Packer, Roger J, Qaddoumi, Ibrahim, Gururangan, Sridharan, Pollack, Ian F, Goldman, Stewart, Doyle, Lawrence A, Stewart, Clinton F, Boyett, James M, Kun, Larry E, Fouladi, Maryam

“…Activation of the mitogen-activated protein kinase pathway is important for growth of pediatric low-grade gliomas (LGGs). The aim of this study was to…”
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Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group by Fangusaro, Jason, Witt, Olaf, Hernáiz Driever, Pablo, Bag, Asim K, de Blank, Peter, Kadom, Nadja, Kilburn, Lindsay, Lober, Robert M, Robison, Nathan J, Fisher, Michael J, Packer, Roger J, Young Poussaint, Tina, Papusha, Ludmila, Avula, Shivaram, Brandes, Alba A, Bouffet, Eric, Bowers, Daniel, Artemov, Anton, Chintagumpala, Murali, Zurakowski, David, van den Bent, Martin, Bison, Brigitte, Yeom, Kristen W, Taal, Walter, Warren, Katherine E

“…Paediatric low-grade gliomas (also known as pLGG) are the most common type of CNS tumours in children. In general, paediatric low-grade gliomas show clinical…”
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Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial by Fisher, Michael J., Shih, Chie-Schin, Rhodes, Steven D., Armstrong, Amy E., Wolters, Pamela L., Dombi, Eva, Zhang, Chi, Angus, Steven P., Johnson, Gary L., Packer, Roger J., Allen, Jeffrey C., Ullrich, Nicole J., Goldman, Stewart, Gutmann, David H., Plotkin, Scott R., Rosser, Tena, Robertson, Kent A., Widemann, Brigitte C., Smith, Abbi E., Bessler, Waylan K., He, Yongzheng, Park, Su-Jung, Mund, Julie A., Jiang, Li, Bijangi-Vishehsaraei, Khadijeh, Robinson, Coretta Thomas, Cutter, Gary R., Korf, Bruce R., Blakeley, Jaishri O., Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma…”
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus by Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Bailey, Simon, Clifford, Steven C., Doz, Francois, Kool, Marcel, Dufour, Christelle, Vassal, Gilles, Milde, Till, Witt, Olaf, von Hoff, Katja, Pietsch, Torsten, Northcott, Paul A., Gajjar, Amar, Robinson, Giles W., Padovani, Laetitia, André, Nicolas, Massimino, Maura, Pizer, Barry, Packer, Roger, Rutkowski, Stefan, Pfister, Stefan M., Taylor, Michael D., Pomeroy, Scott L.

“…Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent…”
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Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights by Khatua, Soumen, Gutmann, David H., Packer, Roger J.

“…Children with neurofibromatosis type 1 (NF1) are predisposed to develop central nervous system neoplasms, the most common of which are low‐grade gliomas…”
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