Search Results - "PACKER, M"

Contrasting effects on the risk of macrovascular and microvascular events of antihyperglycemic drugs that enhance sodium excretion and lower blood pressure by Packer, M.

“…Three classes of anti‐hyperglycaemic medications are distinguished by their urinary sodium excretion‐enhancing and blood pressure‐lowering actions: long‐acting…”
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Dense, unspecific connectivity of neocortical parvalbumin-positive interneurons: a canonical microcircuit for inhibition? by Packer, Adam M, Yuste, Rafael

“…GABAergic interneurons play a major role in the function of the mammalian neocortex, but their circuit connectivity is still poorly understood. We used…”
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The EVO ICL for Moderate Myopia: Results from the US FDA Clinical Trial by Packer, Mark

“…To evaluate the safety and effectiveness of collamer posterior chamber phakic refractive lenses with a central port design (EVO and EVO+ Sphere and Toric…”
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Closed-loop all-optical interrogation of neural circuits in vivo by Zhang, Zihui, Russell, Lloyd E., Packer, Adam M., Gauld, Oliver M., Häusser, Michael

“…Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing…”
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Great expectations, inconvenient truths, and the paradoxes of the dog-owner relationship for owners of brachycephalic dogs by Packer, Rowena M A, O'Neill, Dan G, Fletcher, Francesca, Farnworth, Mark J

“…Popularity of brachycephalic (flat-faced) dog breeds is increasing internationally despite well-documented intrinsic health and welfare problems associated…”
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Impact of Facial Conformation on Canine Health: Brachycephalic Obstructive Airway Syndrome by Packer, Rowena M A, Hendricks, Anke, Tivers, Michael S, Burn, Charlotte C

“…The domestic dog may be the most morphologically diverse terrestrial mammalian species known to man; pedigree dogs are artificially selected for extreme…”
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Two-photon optogenetics of dendritic spines and neural circuits by Packer, Adam M, Peterka, Darcy S, Hirtz, Jan J, Prakash, Rohit, Deisseroth, Karl, Yuste, Rafael

“…Using the red shifted opsin C1V1 T and simple raster-scanning illumination, this work shows two-photon optogenetic stimulation of single cells, dendrites and…”
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Cognitive dysfunction in naturally occurring canine idiopathic epilepsy by Packer, Rowena M A, McGreevy, Paul D, Salvin, Hannah E, Valenzuela, Michael J, Chaplin, Chloe M, Volk, Holger A

“…Globally, epilepsy is a common serious brain disorder. In addition to seizure activity, epilepsy is associated with cognitive impairments including static…”
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The Logic of Inhibitory Connectivity in the Neocortex by Fino, Elodie, Packer, Adam M., Yuste, Rafael

“…Although inhibition plays a major role in the function of the mammalian neocortex, the circuit connectivity of GABAergic interneurons has remained poorly…”
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Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure by McMurray, John J.V, Packer, Milton, Desai, Akshay S, Gong, Jianjian, Lefkowitz, Martin P, Rizkala, Adel R, Rouleau, Jean L, Shi, Victor C, Solomon, Scott D, Swedberg, Karl, Zile, Michael R

“…The angiotensin receptor–neprilysin inhibitor LCZ696 was compared with the ACE inhibitor enalapril in patients with advanced heart failure. LCZ696 was superior…”
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Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation by Prakash, Rohit, Yizhar, Ofer, Grewe, Benjamin, Ramakrishnan, Charu, Wang, Nancy, Goshen, Inbal, Packer, Adam M, Peterka, Darcy S, Yuste, Rafael, Schnitzer, Mark J, Deisseroth, Karl

“…A collection of opsins for two-photon modulation of neuronal activity in vitro and in vivo is presented in this resource. The opsins have kinetic, expression…”
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Proportion and risk factors for death by euthanasia in dogs in the UK by Pegram, Camilla, Gray, Carol, Packer, Rowena M. A., Richards, Ysabelle, Church, David B., Brodbelt, Dave C., O’Neill, Dan G.

“…The loss of a pet can be particularly distressing for owners, whether the method of death is euthanasia or is unassisted. Using primary-care clinical data,…”
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Fast nonnegative deconvolution for spike train inference from population calcium imaging by Vogelstein, Joshua T, Packer, Adam M, Machado, Timothy A, Sippy, Tanya, Babadi, Baktash, Yuste, Rafael, Paninski, Liam

“…Fluorescent calcium indicators are becoming increasingly popular as a means for observing the spiking activity of large neuronal populations. Unfortunately,…”
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Impact of facial conformation on canine health: corneal ulceration by Packer, Rowena M A, Hendricks, Anke, Burn, Charlotte C

“…Concern has arisen in recent years that selection for extreme facial morphology in the domestic dog may be leading to an increased frequency of eye disorders…”
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In search of common developmental and evolutionary origin of the claustrum and subplate by Bruguier, Hannah, Suarez, Rodrigo, Manger, Paul, Hoerder‐Suabedissen, Anna, Shelton, Andrew M., Oliver, David K., Packer, Adam M., Ferran, José L., García‐Moreno, Fernando, Puelles, Luis, Molnár, Zoltán

“…The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the…”
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Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients by Desai, Akshay S, McMurray, John J V, Packer, Milton, Swedberg, Karl, Rouleau, Jean L, Chen, Fabian, Gong, Jianjian, Rizkala, Adel R, Brahimi, Abdel, Claggett, Brian, Finn, Peter V, Hartley, Loren Howard, Liu, Jiankang, Lefkowitz, Martin, Shi, Victor, Zile, Michael R, Solomon, Scott D

“…The angiotensin-receptor-neprilysin inhibitor (ARNI) LCZ696 reduced cardiovascular deaths and all-cause mortality compared with enalapril in patients with…”
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Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012-2022 by Skipper, Alison M, Packer, Rowena M A, O'Neill, Dan G

“…Research into canine health and welfare is supported by Government, charitable and private UK funding organisations. However, there is no current overall…”
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Ultrasequencing of the meiofaunal biosphere: practice, pitfalls and promises by CREER, S., FONSECA, V. G., PORAZINSKA, D. L., GIBLIN-DAVIS, R. M., SUNG, W., POWER, D. M., PACKER, M., CARVALHO, G. R., BLAXTER, M. L., LAMBSHEAD, P. J. D., THOMAS, W. K.

“…Biodiversity assessment is the key to understanding the relationship between biodiversity and ecosystem functioning, but there is a well‐acknowledged…”
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How many neurons are sufficient for perception of cortical activity? by Dalgleish, Henry Wp, Russell, Lloyd E, Packer, Adam M, Roth, Arnd, Gauld, Oliver M, Greenstreet, Francesca, Thompson, Emmett J, Häusser, Michael

“…Many theories of brain function propose that activity in sparse subsets of neurons underlies perception and action. To place a lower bound on the amount of…”
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Prevalence of hearing loss and tinnitus in Iraq and Afghanistan Veterans: A Chronic Effects of Neurotrauma Consortium study by Swan, A.A., Nelson, J.T., Swiger, B., Jaramillo, C.A., Eapen, B.C., Packer, M., Pugh, M.J.

“…The purpose of this study was to describe the prevalence of hearing loss and tinnitus in a cohort of Iraq and Afghanistan Veterans (IAV) with common…”
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