Search Results - "PACK, MICHAEL"

Interactive COVID-19 Mobility Impact and Social Distancing Analysis Platform by Zhang, Lei, Darzi, Aref, Ghader, Sepehr, Pack, Michael L., Xiong, Chenfeng, Yang, Mofeng, Sun, Qianqian, Kabiri, Aliakbar, Hu, Songhua

“…The research team has utilized privacy-protected mobile device location data, integrated with COVID-19 case data and census population data, to produce a…”
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Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease by Ko, Yi-An, Yi, Huiguang, Qiu, Chengxiang, Huang, Shizheng, Park, Jihwan, Ledo, Nora, Köttgen, Anna, Li, Hongzhe, Rader, Daniel J., Pack, Michael A., Brown, Christopher D., Susztak, Katalin

“…Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to 10% of the US population. Genome-wide association studies (GWASs) have…”
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The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17 by Waisbourd‐Zinman, Orith, Koh, Hong, Tsai, Shannon, Lavrut, Pierre‐Marie, Dang, Christine, Zhao, Xiao, Pack, Michael, Cave, Jeff, Hawes, Mark, Koo, Kyung A., Porter, John R., Wells, Rebecca G.

“…Biliary atresia, the most common indication for pediatric liver transplantation, is a fibrotic disease of unknown etiology affecting the extrahepatic bile…”
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All Good Things Come to an End: 5 Years at the Helm of CMGH by Kaestner, Klaus H., Pack, Michael

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Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis by Liu, Ying, Murazzi, Ileana, Fuller, Ashley M, Pan, Hehai, Irizarry-Negron, Valerie M, Devine, Ann, Katti, Rohan, Skuli, Nicolas, Ciotti, Gabrielle E, Pak, Koreana, Pack, Michael A, Simon, M Celeste, Weber, Kristy, Cooper, Kumarasen, Eisinger-Mathason, T S Karin

“…Intratumoral hypoxia correlates with metastasis and poor survival in patients with sarcoma. Using an impedance sensing assay and a zebrafish intravital…”
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Visualizing Change over Time Using Dynamic Hierarchies: TreeVersity2 and the StemView by Guerra-Gomez, JohnAlexis, Pack, Michael L., Plaisant, Catherine, Shneiderman, Ben

“…To analyze data such as the US Federal Budget or characteristics of the student population of a University it is common to look for changes over time. This…”
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CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations by Zheng, Xiangjian, Xu, Chong, Di Lorenzo, Annarita, Kleaveland, Benjamin, Zou, Zhiying, Seiler, Christoph, Chen, Mei, Cheng, Lan, Xiao, Jiping, He, Jie, Pack, Michael A, Sessa, William C, Kahn, Mark L

“…Cerebral cavernous malformation is a common human vascular disease that arises due to loss-of-function mutations in genes encoding three intracellular adaptor…”
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TGFβ and Hippo Pathways Cooperate to Enhance Sarcomagenesis and Metastasis through the Hyaluronan-Mediated Motility Receptor (HMMR) by Ye, Shuai, Liu, Ying, Fuller, Ashley M, Katti, Rohan, Ciotti, Gabrielle E, Chor, Susan, Alam, Md Zahidul, Devalaraja, Samir, Lorent, Kristin, Weber, Kristy, Haldar, Malay, Pack, Michael A, Eisinger-Mathason, T S Karin

“…High-grade sarcomas are metastatic and pose a serious threat to patient survival. Undifferentiated pleomorphic sarcoma (UPS) is a particularly dangerous and…”
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A vertebrate model to reveal neural substrates underlying the transitions between conscious and unconscious states by Bedell, Victoria M., Meng, Qing C., Pack, Michael A., Eckenhoff, Roderic G.

“…The field of neuropharmacology has not yet achieved a full understanding of how the brain transitions between states of consciousness and drug-induced…”
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Protein‐elongating mutations in MYH11 are implicated in a dominantly inherited smooth muscle dysmotility syndrome with severe esophageal, gastric, and intestinal disease by Gilbert, Melissa A., Schultz‐Rogers, Laura, Rajagopalan, Ramakrishnan, Grochowski, Christopher M., Wilkins, Benjamin J., Biswas, Sawona, Conlin, Laura K., Fiorino, Kristin N., Dhamija, Radhika, Pack, Michael A., Klee, Eric W., Piccoli, David A., Spinner, Nancy B.

“…Gastrointestinal motility disorders include a spectrum of mild to severe clinical phenotypes that are caused by smooth muscle dysfunction. We investigated the…”
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Wide-bandwidth, tunable, multiple-pulse-width optical delays using slow light in cesium vapor by Camacho, Ryan M, Pack, Michael V, Howell, John C, Schweinsberg, Aaron, Boyd, Robert W

“…We demonstrate an all-optical delay line in hot cesium vapor that tunably delays 275 ps input pulses up to 6.8 ns and 740 input ps pulses up to 59 ns (group…”
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Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia by McKinstry-Wu, Andrew R, Wasilczuk, Andrzej Z, Harrison, Benjamin A, Bedell, Victoria M, Sridharan, Mathangi J, Breig, Jayce J, Pack, Michael, Kelz, Max B, Proekt, Alexander

“…Traditionally, drug dosing is based on a concentration-response relationship estimated in a population. Yet, in specific individuals, decisions based on the…”
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Smooth muscle tension induces invasive remodeling of the zebrafish intestine by Seiler, Christoph, Davuluri, Gangarao, Abrams, Joshua, Byfield, Fitzroy J, Janmey, Paul A, Pack, Michael

“…The signals that initiate cell invasion are not well understood, but there is increasing evidence that extracellular physical signals play an important role…”
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Analysis of the Zebrafish Proteome during Embryonic Development by Lucitt, Margaret B., Price, Thomas S., Pizarro, Angel, Wu, Weichen, Yocum, Anastasia K., Seiler, Christoph, Pack, Michael A., Blair, Ian A., FitzGerald, Garret A., Grosser, Tilo

“…The model organism zebrafish (Danio rerio) is particularly amenable to studies deciphering regulatory genetic networks in vertebrate development, biology, and…”
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p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis by Wilkins, Benjamin J, Lorent, Kristin, Matthews, Randolph P, Pack, Michael

“…North American Indian Childhood Cirrhosis (NAIC) is a rare, autosomal recessive, progressive cholestatic disease of infancy affecting the Cree-Ojibway first…”
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CMGH: The year in review by Kaestner, Klaus H., Pack, Michael

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To the Readers, Contributors, Reviewers, and Friends of CMGH by Kaestner, Klaus H, Pack, Michael

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Identification of novel inhibitors of dietary lipid absorption using zebrafish by Clifton, Justin D, Lucumi, Edinson, Myers, Michael C, Napper, Andrew, Hama, Kotaro, Farber, Steven A, Smith, 3rd, Amos B, Huryn, Donna M, Diamond, Scott L, Pack, Michael

“…Pharmacological inhibition of dietary lipid absorption induces favorable changes in serum lipoprotein levels in patients that are at risk for cardiovascular…”
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Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy by Lorent, Kristin, Yeo, Sang-Yeob, Oda, Takaya, Chandrasekharappa, Settara, Chitnis, Ajay, Matthews, Randolph P, Pack, Michael

“…The Alagille Syndrome (AGS) is a heritable disorder affecting the liver and other organs. Causative dominant mutations in human Jagged 1 have been identified…”
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Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas by Esni, Farzad, Ghosh, Bidyut, Biankin, Andrew V, Lin, John W, Albert, Megan A, Yu, Xiaobing, MacDonald, Raymond J, Civin, Curt I, Real, Francisco X, Pack, Michael A, Ball, Douglas W, Leach, Steven D

“…Notch signaling regulates cell fate decisions in a variety of adult and embryonic tissues, and represents a characteristic feature of exocrine pancreatic…”
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