Search Results - "P.-C. Klöhn"

A Quantitative, Highly Sensitive Cell-Based Infectivity Assay for Mouse Scrapie Prions by P. -C. Klöhn, Stoltze, L., Flechsig, E., Enari, M., Weissmann, C.

“…Prions are usually quantified by bioassays based on intracerebral inoculation of mice that are slow, imprecise, and costly. We have isolated neuroblastoma N2a…”
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Transmission of Prions by Weissmann, C., Enari, M., Klöhn, P-C., Rossi, D., Flechsig, E.

“…The “protein only” hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host…”
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Transmission of Prions by Weissmann, C., Enari, M., P.-C. Klöhn, Rossi, D., Flechsig, E.

“…The "protein only" hypothesis states that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host…”
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Genotoxic and chronic toxic effects in the carcinogenicity of aromatic amines by Bitsch, A, Fecher, J, Jost, M, Klöhn, P C, Neumann, H G

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Redox Regulation in Mammalian Signal Transduction by Gulati, Pawan, Klöhn, Peter‐Christian, Krug, Harald, Göttlicher, Martin, Markova, Boyka, Böhmer, Frank‐D., Herrlich, Peter

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New insights into carcinogenesis of the classical model arylamine 2-acetylaminofluorene by Bitsch, Annette, Klöhn, Peter-Christian, Hadjiolov, Nikolai, Bergmann, Ole, Neumann, Hans-Günter

“…2-Acetylaminofluorene (AAF) is a complete carcinogen in rat liver. The genotoxic effects of reactive metabolites are considered necessary but not sufficient to…”
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Mitochondrial permeability transition is altered in early stages of carcinogenesis of 2-acetylaminofluorene by KLÖHN, P.-C, BITSCH, A, NEUMANN, H.-G

“…The tumour promoting properties of carcinogenic 2-acetylaminofluorene (AAF) in rat liver are essentially unknown. We proposed that mitochondria are a target…”
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Dose Response of Early Effects Related to Tumor Promotion of 2-Acetylaminofluorene by Bitsch, Annette, Hadjiolov, Nikolai, Klöhn, Peter-Christian, Bergmann, Ole, Zwirner-Baier, Iris, Neumann, Hans-Günter

“…The genotoxic effects of 2-acetylaminofluorene (AAF) alone cannot explain the formation of rat liver tumors. It has been proposed that mitochondrial effects…”
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The dual role of 2-acetylaminofluorene in hepatocarcinogenesis: specific targets for initiation and promotion by Neumann, H G, Bitsch, A, Klöhn, P C

“…2-Acetylaminofluorene (AAF) is one of the most widely studied model carcinogens. It produces liver tumors in rats. Comparison with other arylamides shows that…”
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Impairment of respiration and oxidative phosphorylation by redox cyclers 2-nitrosofluorene and menadione by Klöhn, Peter-Christian, Neumann, Hans-Günter

“…The present study was designed to investigate the effects of 2-nitrosofluorene (NOF), a metabolite of carcinogenic 2-acetylaminofluorene, on mitochondrial…”
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A metabolite of carcinogenic 2-acetylaminofluorene, 2-nitrosofluorene, induces redox cycling in mitochondria by Klöhn, Peter-Christian, Massalha, Husam, Neumann, Hans-Günter

“…The present study was designed to confirm the recent proposal that 2-nitrosofluorene (2-NOF) as well as N-hydroxy-2-aminofluorene (N-OH-AF) induce a…”
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Chronic toxicity of the hepatocarcinogen 2-AAF is related to an impairment of mitochondrial energy conversion by Klöhn, P. -C., Neumann, H. -G.

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Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis by Mallucci, Giovanna, Dickinson, Andrew, Linehan, Jacqueline, Klöhn, Peter-Christian, Brandner, Sebastian, Collinge, John

“…The mechanisms involved in prion neurotoxicity are unclear, and therapies preventing accumulation of PrPSc, the disease-associated form of prion protein (PrP),…”
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2-Nitrosofluorene and N-hydroxy-2-aminofluorene react with the ubiquinone-reduction center (center N) of the mitochondrial cytochrome bc1 complex by Klöhn, Peter-Christian, Brandt, Ulrich, Neumann, Hans-Günter

“…We determined the sites of artificial electron transfer onto 2-nitrosofluorene (NOF), a metabolite of carcinogenic 2-acetylaminofluorene in mitochondria and…”
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Identification of a gene regulatory network associated with prion replication by Marbiah, Masue M, Harvey, Anna, West, Billy T, Louzolo, Anais, Banerjee, Priya, Alden, Jack, Grigoriadis, Anita, Hummerich, Holger, Kan, Ho-Man, Cai, Ying, Bloom, George S, Jat, Parmjit, Collinge, John, Klöhn, Peter-Christian

“…Prions consist of aggregates of abnormal conformers of the cellular prion protein (PrP C ). They propagate by recruiting host‐encoded PrP C although the…”
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Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions by Heikenwalder, Mathias, Zeller, Nicolas, Seeger, Harald, Prinz, Marco, Klöhn, Peter-Christian, Schwarz, Petra, Ruddle, Nancy H, Weissmann, Charles, Aguzzi, Adriano

“…Prions typically accumulate in nervous and lymphoid tissues. Because proinflammatory cytokines and immune cells are required for lymphoid prion replication, we…”
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Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis by Kristiansen, Mark, Messenger, Marcus J., Klöhn, Peter-Christian, Brandner, Sebastian, Wadsworth, Jonathan D.F., Collinge, John, Tabrizi, Sarah J.

“…The molecular basis for neuronal death in prion disease is not established, but putative pathogenic roles for both disease-related prion protein (PrPSc) and…”
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Early Resistance to Cell Death and to Onset of the Mitochondrial Permeability Transition during Hepatocarcinogenesis with 2-Acetylaminofluorene by Klöhn, Peter-Christian, Soriano, Maria Eugenia, Irwin, William, Penzo, Daniele, Scorrano, Luca, Bitsch, Annette, Neumann, Hans-Günter, Bernardi, Paolo

“…A hallmark of tumorigenesis is resistance to apoptosis. To explore whether resistance to cell death precedes tumor formation, we have studied the short-term…”
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Cellular prion replication is controlled by expression of extracellular matrix proteins by Marbiah, MM, Harvey, A, West, BT, Louzolo, A, Banerjee, P, Alden, J, Grigoriadis, A, Hummerich, H, Kan, HM, Cai, Y, Bloom, GS, Jat, P, Collinge, J, Klohn, PC

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Molecular biology of prions by Weissmann, Charles, Enari, Masato, Klöhn, Peter-Christian, Rossi, Daniela, Flechsig, Eckhard

“…The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host…”
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