Hemorheological system in coronary heart disease patients: prognostic value

Aim. To develop highly sensitive prognostic methods for coronary heart disease (CHD) and acute coronary event (ACE) risk stratification, on the basis of biophysical hemorheological system assessment. Material and methods. Seven-year follow-up data on CHD patients were analyzed: re-hospitalization ra...

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Bibliographic Details
Published in:	Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika Vol. 6; no. 3; pp. 19 - 24
Main Authors:	L. I. Malinova, P. Yu. Dovgalevsky
Format:	Journal Article
Language:	Russian
Published:	SILICEA-POLIGRAF» LLC 01-06-2007
Subjects:	acute coronary event coronary heart disease hemorheology prognosis
Online Access:	Get full text
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Summary:	Aim. To develop highly sensitive prognostic methods for coronary heart disease (CHD) and acute coronary event (ACE) risk stratification, on the basis of biophysical hemorheological system assessment. Material and methods. Seven-year follow-up data on CHD patients were analyzed: re-hospitalization rate and reasons; main hemorheological parameters, their temporal and velocity characteristics; hemorheological system modeling by creating phase fragments in multi-dimensional phase space. Results. Whole blood viscosity was significantly higher in patients with 3 or more ACE, comparing to ACE-free individuals or participants with <3 ACE. Velocity parameter dynamics correlated with ACE hospitalization rate. Phase fragment method demonstrated hemorheological system destabilization, maximal in patients with 3 or more ACE. Conclusion. Prognostic value of whole blood viscosity and velocity assessment was demonstrated in CHD patients. Various CHD therapy algorithms, depending on hemorheological parameters and ACE risk, were developed.
ISSN:	1728-8800 2619-0125