Search Results - "P. Witz, Isaac"

The selectin–selectin ligand axis in tumor progression by Witz, Isaac P.

“…This review will document that the selectin–selectin ligand axis is actively involved in tumor progression and drives this process. The involvement of…”
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Yin-Yang Activities and Vicious Cycles in the Tumor Microenvironment by WITZ, Isaac P

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The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching by Lessard, Laurent, Liu, Michelle, Marzese, Diego M., Wang, Hongwei, Chong, Kelly, Kawas, Neal, Donovan, Nicholas C., Kiyohara, Eiji, Hsu, Sandy, Nelson, Nellie, Izraely, Sivan, Sagi-Assif, Orit, Witz, Isaac P., Ma, Xiao-Jun, Luo, Yuling, Hoon, Dave S.B.

“…In recent years, considerable advances have been made in the characterization of protein-coding alterations involved in the pathogenesis of melanoma. However,…”
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A history of exploring cancer in context by Maman, Shelly, Witz, Isaac P.

“…The concept that progression of cancer is regulated by interactions of cancer cells with their microenvironment was postulated by Stephen Paget over a century…”
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Epigenetic Changes of EGFR Have an Important Role in BRAF Inhibitor–Resistant Cutaneous Melanomas by Wang, Jinhua, Huang, Sharon K., Marzese, Diego M., Hsu, Sandy C., Kawas, Neal P., Chong, Kelly K., Long, Georgina V., Menzies, Alexander M., Scolyer, Richard A., Izraely, Sivan, Sagi-Assif, Orit, Witz, Isaac P., Hoon, Dave S.B.

“…BRAF mutations are frequent in cutaneous melanomas, and BRAF inhibitors (BRAFi) have shown remarkable clinical efficacy in BRAF mutant melanoma patients…”
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Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis by Ramos, Romela Irene, Bustos, Matias A., Wu, Jinfeng, Jones, Peter, Chang, Shu Ching, Kiyohara, Eiji, Tran, Kevin, Zhang, Xiaoqing, Stern, Stacey L., Izraely, Sivan, Sagi‐Assif, Orit, Witz, Isaac P., Davies, Michael A., Mills, Gordon B., Kelly, Daniel F., Irie, Reiko F., Hoon, Dave S. B.

“…Melanoma metastasis to the brain is one of the most frequent extracranial brain tumors. Cell surface gangliosides are elevated in melanoma metastasis; however,…”
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CXCL10 promotes invasion-related properties in human colorectal carcinoma cells by ZIPIN-ROITMAN, Adi, MESHEL, Tsipi, SAGI-ASSIF, Orit, SHALMON, Bruria, AVIVI, Camila, PFEFFER, Raphael M, WITZ, Isaac P, BEN-BARUCH, Adit

“…CXCL10 was recently shown to exert antimalignancy functions by influencing the tumor microenvironment. Here, we have taken a different approach, investigating…”
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The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells – a case of inter‐tumor heterogeneity by Izraely, Sivan, Ben‐Menachem, Shlomit, Sagi‐Assif, Orit, Meshel, Tsipi, Malka, Sapir, Telerman, Alona, Bustos, Matias A., Ramos, Romela Irene, Pasmanik‐Chor, Metsada, Hoon, Dave S. B., Witz, Isaac P.

“…The melanoma‐microglia cross‐talk upregulates the expression of aldolase C (ALDOC) in melanoma cells from several patients. The response of melanoma cells from…”
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The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis by Izraely, Sivan, Sagi-Assif, Orit, Klein, Anat, Meshel, Tsipi, Tsarfaty, Galia, Pasmanik-Chor, Metsada, Nahmias, Clara, Couraud, Pierre-Olivier, Ateh, Eugene, Bryant, Joseph L., Hoon, Dave S.B., Witz, Isaac P.

“…Brain metastasis occurs frequently in melanoma patients with advanced disease whereby the prognosis is dismal. The underlying mechanisms of melanoma brain…”
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The metastatic microenvironment: Claudin‐1 suppresses the malignant phenotype of melanoma brain metastasis by Izraely, Sivan, Sagi‐Assif, Orit, Klein, Anat, Meshel, Tsipi, Ben‐Menachem, Shlomit, Zaritsky, Assaf, Ehrlich, Marcelo, Prieto, Victor G., Bar‐Eli, Menashe, Pirker, Christine, Berger, Walter, Nahmias, Clara, Couraud, Pierre‐Olivier, Hoon, Dave S.B., Witz, Isaac P.

“…Brain metastases occur frequently in melanoma patients with advanced disease whereby the prognosis is dismal. The underlying mechanisms of melanoma brain…”
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The cross talk between cancer cells and their microenvironments by Witz, Isaac P.

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Regeneration Enhances Metastasis: A Novel Role for Neurovascular Signaling in Promoting Melanoma Brain Metastasis by Prakash, Roshini, Izraely, Sivan, Thareja, Nikita S, Lee, Rex H, Rappaport, Maya, Kawaguchi, Riki, Sagi-Assif, Orit, Ben-Menachem, Shlomit, Meshel, Tsipi, Machnicki, Michal, Ohe, Shuichi, Hoon, Dave S, Coppola, Giovanni, Witz, Isaac P, Carmichael, S Thomas

“…Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in…”
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The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway by Izraely, Sivan, Ben-Menachem, Shlomit, Malka, Sapir, Sagi-Assif, Orit, Bustos, Matias A, Adir, Orit, Meshel, Tsipi, Chelladurai, Maharrish, Ryu, Suyeon, Ramos, Romela I, Pasmanik-Chor, Metsada, Hoon, Dave S B, Witz, Isaac P

“…Previous studies from our lab demonstrated that the crosstalk between brain-metastasizing melanoma cells and microglia, the macrophage-like cells of the…”
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A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma by Geminder, Hila, Sagi-Assif, Orit, Goldberg, Lilach, Meshel, Tsipi, Rechavi, Gideon, Witz, Isaac P, Ben-Baruch, Adit

“…The homing of hemopoietic stem cells to the bone marrow is mediated by specific interactions occurring between CXCR4, which is expressed on hemopoietic stem…”
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Site‐specific metastasis: A cooperation between cancer cells and the metastatic microenvironment by Izraely, Sivan, Witz, Isaac P.

“…The conclusion derived from the information provided in this review is that disseminating tumor cells (DTC) collaborate with the microenvironment of a future…”
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Inter-Tumor Heterogeneity-Melanomas Respond Differently to GM-CSF-Mediated Activation by Moshe, Adi, Izraely, Sivan, Sagi-Assif, Orit, Malka, Sapir, Ben-Menachem, Shlomit, Meshel, Tsipi, Pasmanik-Chor, Metsada, Hoon, Dave S B, Witz, Isaac P

“…Granulocyte-monocyte colony stimulating factor (GM-CSF) is used as an adjuvant in various clinical and preclinical studies with contradictory results. These…”
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Cancer drug resistance induced by EMT: novel therapeutic strategies by De Las Rivas, Javier, Brozovic, Anamaria, Izraely, Sivan, Casas-Pais, Alba, Witz, Isaac P., Figueroa, Angélica

“…Over the last decade, important clinical benefits have been achieved in cancer patients by using drug-targeting strategies. Nevertheless, drug resistance is…”
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The Tumor Microenvironment: The Making of a Paradigm by Witz, Isaac P.

“…What has been will be again, what has been done will be done again; there is nothing new under the sun (Ecclesiastes 1:9) Stephen Paget was the conceptual…”
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Corrigendum to “P-REX1 amplification promotes progression of cutaneous melanomavia the PAK1/P38/MMP-2 pathway” [Cancer Lett. 407 (2017) 66–75] by Wang, Jinhua, Hirose, Hajime, Du, Guanhua, Chong, Kelly, Kiyohara, Eiji, Witz, Isaac P., Hoon, Dave S.B.

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Hexokinase 2 is a determinant of neuroblastoma metastasis by Edry Botzer, Liat, Maman, Shelly, Sagi-Assif, Orit, Meshel, Tsipi, Nevo, Ido, Yron, Ilana, Witz, Isaac P

“…Background: Intersecting a genome-wide expression profile of metastatic and nonmetastatic human neuroblastoma xenograft variants with expression profiles of…”
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