Search Results - "P. V. Spirin"

The Role of Autophagy in the Development of Pathological Conditions of the Body by Kench, U S, Sologova, S S, Prassolov, V S, Spirin, P V

“…Autophagy is the process of lysosomal elimination of the cell organelles, cytoplasmic sites, and pathogenic microorganisms that enter the cell. This process is…”
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Activated leukemic oncogenes AML1-ETO and c-kit: Role in development of acute myeloid leukemia and current approaches for their inhibition by Rulina, A. V, Spirin, P. V, Prassolov, V. S

“…Acute myeloid leukemia (AML) is a malignant blood disease caused by different mutations that enhance the pro-liferative activity and survival of blood cells…”
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Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling by Spirin, P V, Lebedev, T D, Orlova, N N, Gornostaeva, A S, Prokofjeva, M M, Nikitenko, N A, Dmitriev, S E, Buzdin, A A, Borisov, N M, Aliper, A M, Garazha, A V, Rubtsov, P M, Stocking, C, Prassolov, V S

“…The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding…”
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Replication protein A modulates the activity of human telomerase in vitro by Rubtsova, M. P, Skvortsov, D. A, Petruseva, I. O, Lavrik, O. I, Spirin, P. V, Prasolov, V. S, Kisseljov, F. L, Dontsova, O. A

“…Our aim was to investigate how replication protein A (RPA) in a wide range of concentration can regulate the activity of human telomerase. We used an in vitro…”
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Plasmolipin and Its Role in Cell Processes by Shulgin, A. A., Lebedev, T. D., Prassolov, V. S., Spirin, P. V.

“…The mechanisms involved in the origin and development of malignant and neurodegenerative diseases are an important area of modern biomedicine. A crucial task…”
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Activated leukemic oncogenes responsible for neoplastic transformation of hematopoietic cells by Baskaran, D, Spirin, P. V, Prassolov, V. S

“…Leukemias are a heterogeneous group of malignant blood diseases that are characterized by expansion of immature blast cells. The point molecular mechanisms of…”
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The Role of TAL1 in Hematopoiesis and Leukemogenesis by Vagapova, E R, Spirin, P V, Lebedev, T D, Prassolov, V S

“…TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates…”
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The Role of the MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation by Shyrokova, Elena Yu, Prassolov, Vladimir S., Spirin, Pavel V.

“…The mutations associated with malignant cell transformation are believed to disrupt the expression of a significant number of normal, non-mutant genes. The…”
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Lentiviral gene delivery to plasmolipin-expressing cells using Mus caroli endogenous retrovirus envelope protein by Prokofjeva, M.M., Proshkina, G.M., Lebedev, T.D., Shulgin, A.A., Spirin, P.V., Prassolov, V.S., Deyev, S.M.

“…Gene therapy is a promising method for treating malignant diseases. One of the main problems is target delivery of therapeutic genes. Here we show that…”
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Inhibition of Non-Receptor Tyrosine Kinase JAK2 Reduces Neuroblastoma Cell Growth and Enhances the Action of Doxorubicin by Lebedev, T. D., Vagapova, E. R., Astashkova, O. O., Spirin, P. V., Prassolov, V. S.

“…—Novel treatments for various types of malignant diseases are warranted. In this study, we evaluated JAK2 inhibitors (Janus kinase 2) for suppressing the…”
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Baculovirus vectors for efficient gene delivery and expression in mammalian cells by Koroleva, N. N, Spirin, P. V, Timokhova, A. V, Rubtzov, P. M, Kochetkov, S. N, Prasolov, V. S, Beljelarskaya, S. N

“…Baculovirus expression vectors are extensively used for the delivery of foreign genes and expression of recombinant proteins in insect and mammalian cells…”
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Downregulation of activated leukemic oncogenes AML1-ETO and RUNX1(K83N) expression with RNA-interference by Spirin, P. V, Baskaran, D, Orlova, N. N, Rulina, A. V, Nikitenko, N. A, Chernolovskaya, E. L, Zenkova, M. A, Vlassov, V. V, Rubtsov, P. M, Chumakov, P. M, Stocking, C, Prassolov, V. S

“…In the present study, we have applied the siRNA approach to reduce the expression of AML1-ETO and RUNX1(K83N) oncogenes, which are frequently found in leukemic…”
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High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin by Vagapova, E R, Lebedev, T D, Tikhonova, A D, Goikhman, B V, Ivanenko, K A, Spirin, P V, Prassolov, V S

“…Acute myeloid leukemia (AML) is a genetically heterogeneous group of oncological diseases of the hematopoietic system, which are extremely difficult to treat…”
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High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin by Vagapova, E. R., Lebedev, T. D., Tikhonova, A. D., Goikhman, B. V., Ivanenko, K. A., Spirin, P. V., Prassolov, V. S.

“…—Acute myeloid leukemia (AML) is a genetically heterogeneous group of oncological diseases of the hematopoietic system, which are extremely difficult to treat…”
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Establishment of a FDC-P1 murine cell line with human KIT N822K gene overexpression by Vagapova, Elmira R., Lebedev, T. D., Popenko, V. I., Leonova, O. G., Spirin, P. V., Prasolov, V. S.

“…The mechanism of resistance of leukemia cells to chemotherapeutic drugs remains poorly understood. New model systems for studying the processes of malignant…”
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Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia by Orlova, N. N., Lebedev, T. D., Spirin, P. V., Prassolov, V. S.

“…Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most…”
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Transfer and Expression of Small Interfering RNAs in Mammalian Cells Using Lentiviral Vectors by Lebedev, T D, Spirin, P V, Prassolov, V S

“…RNA interference is a convenient tool for modulating gene expression. The widespread application of RNA interference is made difficult because of the…”
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Comparative analysis of gene expression: Targeted antitumor therapy in neuroblastoma cell lines by Lebedev, T. D., Spirin, P. V., Orlova, N. N., Prokofjeva, M. M., Prassolov, V. S.

“…In this study, we evaluated the level of c-kit, VEGFA , and MYC gene expression in seven neuroblastoma stable cell lines, i.e., SK-N-SH, SK-N-BE, SK-N-AS,…”
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Ribonuclease binase induces death in T-cell acute lymphoblastic leukemia cells by apoptosis by Burnysheva, K. M., Petrushanko, I. Yu, Spirin, P. V., Prassolov, V. S., Makarov, A. A., Mitkevich, V. A.

“…Bacterial ribonuclease binase is a potential anticancer agent. In the present study, we have determined the toxic effect of binase towards cell lines of T-cell…”
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Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer by Kuznetsova, E. S., Zinovieva, O. L., Oparina, N. Yu, Prokofjeva, M. M., Spirin, P. V., Favorskaya, I. A., Zborovskaya, I. B., Lisitsyn, N. A., Prassolov, V. S., Mashkova, T. D.

“…Retinoids are signaling molecules that control a wide variety of cellular processes and possess antitumor activity. This work presents a comprehensive…”
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