Search Results - "P. Sportoletti"

A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice by Mupo, A, Celani, L, Dovey, O, Cooper, J L, Grove, C, Rad, R, Sportoletti, P, Falini, B, Bradley, A, Vassiliou, G S

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Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications by Sportoletti, P, Varasano, E, Rossi, R, Mupo, A, Tiacci, E, Vassiliou, G, Martelli, M P, Falini, B

“…Acute myeloid leukemia (AML) carrying nucleophosmin ( NPM1 ) mutations displays distinct biological and clinical features that led to its inclusion as a…”
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Choice of Frontline Tyrosine-Kinase Inhibitor and Early Events in Very Elderly Patients With Chronic Myeloid Leukemia in Chronic Phase: A "Campus CML" Study by Bucelli, C, Capodanno, I, Miggiano, M C, Cavazzini, F, Crescenzi, S Leonetti, Russo, S, Carmosino, I, Annunziata, M, Sorà, F, Bonifacio, M, Luciano, L, Caocci, G, Loglisci, G, Elena, C, Lunghi, F, Mullai, R, Attolico, I, Binotto, G, Crisà, E, Sportoletti, P, Di Veroli, A, Scortechini, A R, Leporace, A P, Maggi, A, Crugnola, M, Stagno, F, Sancetta, R, Murgano, P, Rapezzi, D, Luzi, D, Vincelli, D I, Galimberti, S, Bocchia, M, Fava, C, Malato, A, Abruzzese, E, Saglio, G, Specchia, G, Breccia, M, Iurlo, A, Tiribelli, M, Latagliata, R

“…The study aimed to evaluate the utilization of frontline TKI therapy in a large cohort of elderly CP-CML patients. A retrospective analysis was conducted on…”
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FLT3-targeted therapy restores GATA1 pathway function in NPM1/FLT3-ITD mutated acute myeloid leukaemia by Sorcini, D, Stella, A, Scialdone, A, Sartori, S, Marra, A, Rossi, R, De Falco, F, Adamo, F M, Dorillo, E, Geraci, C, Arcaleni, R, Rompietti, C, Esposito, A, Moretti, L, Mameli, M G, Martelli, M P, Falini, B, Sportoletti, P

“…One-third of newly diagnosed adult acute myeloid leukaemia (AML) carry mutations, which frequently occur together with nucleophosmin ( ) mutations and are…”
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A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia by Sportoletti, P, Baldoni, S, Del Papa, B, Aureli, P, Dorillo, E, Ruggeri, L, Plebani, S, Amico, V, Di Tommaso, A, Rosati, E, Marconi, P, Di Ianni, M, Falzetti, F

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TRACKING CLONAL HEMATOPOIESIS IN PATIENTS WITH CLASSICAL HODGKIN'S LYMPHOMA by Marra, A., Venanzi, A, Schiavoni, G., Milner, S. G., Limongello, R., Santi, A., Pettirossi, V., Ultimo, S., Tasselli, L., Pucciarini, A., Falini, L., Sciabolacci, S., Martelli, M. P., Sportoletti, P., Ascani, S., Falini, B., Tiacci, E.

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The NOTCH1/CD39 axis: a Treg trip-switch for GvHD by Del Papa, B, Pierini, A, Sportoletti, P, Baldoni, S, Cecchini, D, Rosati, E, Dorillo, E, Aureli, P, Zei, T, Iacucci Ostini, R, Ruggeri, L, Carotti, A, Velardi, A, Negrin, R, Martelli, M F, Falzetti, F, Di Ianni, M

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Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation by De Falco, F, Sabatini, R, Falzetti, F, Di Ianni, M, Sportoletti, P, Baldoni, S, Del Papa, B, Screpanti, I, Marconi, P, Rosati, E

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EFFICACY AND DISCONTINUATION RATE OF IBRUTINIB IN TREATMENT NAIVE CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITH TP53 ABNORMALITIES. A REAL‐LIFE CAMPUS CLL STUDY by Visentin, A., Mauro, F. R., Cibien, F., Vitale, C., Reda, G., Fresa, A., Ciolli, S., Pietrasanta, D., Marchetti, M., Murru, R., Gentile, M., Rigolin, G. M., Quaglia, F. M., Scarfò, L., Sportoletti, P., Pravato, S., Romano Gargarella, L., Facco, M., Piazza, F., Coscia, M., Laurenti, L., Molica, S., Pizzolo, G., Foà, R., Cuneo, A., Trentim, L.

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P664: GRADING QUALITY OF EVIDENCE AND STRENGTH OF RECOMMENDATIONS FOR THE TREATMENT OF RELAPSED/REFRACTORY CLL by Molica, S., Patti, C., Sportoletti, P., Chiarenza, A., Giordano, A. M., Chiurazzi, F., Di Renzo, N., Musto, P., Pane, F., Di Raimondo, F., Trentin, L., Mauro, F. R., Giannarelli, D.

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P458: TRANSCRIPTIONAL AND TRANSLATIONAL SIGNATURES OF TRIPLE MUTATED DNMT3AKO/FLT3ITD/NPM1C MICE SHOW ALTERED RNAS PROCESSING AND CELL CYCLE PROGRESSION by Scialdone, A., Sorcini, D., Stella, A., Tini, V., Marra, A., Rompietti, C., De Falco, F., Dorillo, E., Adamo, F. M., Barcelos, E. C., Arcaleni, R., Martelli, M. P., Sportoletti°, P., Falini°;° co‐last author, B.

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S139: BCOR DELETION SUSTAINS NOTCH1 SIGNALLING ACTIVATION TO ACCELERATE CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PROGRESSION TOWARD RICHTER TRANSFORMATION IN MICE by Rompietti, C., Sorcini, D., De Falco, F., Dorillo, E., Adamo, F. M., Silva Barcelos, E. C., Stella, A., Scialdone, A., Esposito, A., Arcaleni, R., Bigerna, B., Martino, G., Moretti, L., Mameli, M. G., Geraci, C., Sandoletti, L., Cipiciani, A., Rosati, E., Falini, B., Sportoletti, P.

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P712: ASCIMINIB ITALIAN MANAGED ACCESS PROGRAM: EFFICACY PROFILE IN HEAVILY PRE‐TREATED CML PATIENTS by Breccia, M., Russo Rossi, A. V., Martino, B., Abruzzese, E., Annunziata, M., Binotto, G., Ermacora, A., Fava, C., Giaccone, L., Giai, V., Nardozza, A. P., Coco, P., Gozzini, A., Levato, L., Lucchesi, A., Luciano, L., Maria Cristina, M., Rege‐Cambrin, G., Santoro, M., Scappini, B., Scortechini, A. R., Sportoletti, P., Trabacchi, E., Castagnetti, F.

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P660: SEROLOGIC RESPONSE TO THE SECOND AND THIRD DOSE OF THE SARS‐COV‐2 VACCINE IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: RESULTS OF A PROSPECTIVE, CENTRALIZED, MULTICENTER STUDY by Mauro, F. R., Giannarelli, D., Galluzzo, C., Visentin, A., Frustaci, A. M., Sportoletti, P., Vitale, C., Reda, G., Gentile, M., Levato, L., Murru, R., Armiento, D., Ielo, C., Maglione, R., Crisanti, E., Cipiciani, A., Mattiello, V., Gianfelici, V., Barabino, L., Amici, R., Coscia, M., Tedeschi, A., Trentin, L., Baroncelli, S.

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The glucocorticoid‐induced TNF receptor family‐related protein (GITR) is critical to the development of acute pancreatitis in mice by Galuppo, M, Nocentini, G, Mazzon, E, Ronchetti, S, Esposito, E, Riccardi, L, Sportoletti, P, Di Paola, R, Bruscoli, S, Riccardi, C, Cuzzocrea, S

“…BACKGROUND AND PURPOSE Pancreatitis represents a life‐threatening inflammatory condition where leucocytes, cytokines and vascular endothelium contribute to the…”
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The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence by CHENG, K, GRISENDI, S, CLOHESSY, J. G, MAJID, S, BERNARDI, R, SPORTOLETTI, P, PANDOLFI, P. P

“…Mutations leading to aberrant cytoplasmic localization of Nucleophosmin 1 (NPM1) have been recently identified as the most frequent genetic alteration in acute…”
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Notch1 modulates MSC-mediated regulatory T cell induction by Di Ianni, M, Del Papa, B, Sportoletti, P, Baldoni, S, Cecchini, D, Falzetti, F

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Recurrent primary plasmacytoma of the eyelid with rapid regional metastasis by Ria, R., Di Ianni, M., Sportoletti, P., Cimminiello, M., Marcomigni, L., Tabilio, A.

“…In this case, originally reported as primary eyelid plasmacytoma, the tumor recurred on the same eyelid within 2 years of surgery. No plasma cell infiltration…”
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Mesenchymal cells: a vehicle for gene therapy by Di Ianni, M., Del Papa, B., De Ioanni, M., Sportoletti, P., Moretti, L., Falzetti, F., Martelli, M.F., Tabilio, A.

“…T cell-depleted allogeneic stem cell transplantation is associated with delayed immunological reconstitution. Bone marrow stroma and interleukin 7 (IL-7)…”
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Treatment-Free Remission (TFR) after Two Different Durations of Nilotinib Consolidation in Patients with Chronic Myeloid Leukemia (CML) Previously Treated with Imatinib: Enestpath Study Results by Rea, Delphine, Kyrcz-Krzemien, Slawomira, Sportoletti, Paolo, Mayer, Jiří, Illes, Arpad, Angona, Anna, Kiani, Alexander, Charbonnier, Aude, Marinakis, Theodoros, Stenke, Leif, Weltermann, Ansgar, Shah, Seema, Supekar, Sharon, Di Caprio, Luigi, Baccarani, Michele

“…Background TFR following cessation of tyrosine kinase inhibitor (TKI) therapy is increasingly regarded as a feasible objective for many patients (pts) with CML…”
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