Search Results - "P. Sandoval"

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes by Cinti, Francesca, Bouchi, Ryotaro, Kim-Muller, Ja Young, Ohmura, Yoshiaki, Sandoval, P. R, Masini, Matilde, Marselli, Lorella, Suleiman, Mara, Ratner, Lloyd E, Marchetti, Piero, Accili, Domenico

“…Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies show that β-cells become dedifferentiated in diabetes, reverting to…”
Get full text

High contiguity Arabidopsis thaliana genome assembly with a single nanopore flow cell by Michael, Todd P., Jupe, Florian, Bemm, Felix, Motley, S. Timothy, Sandoval, Justin P., Lanz, Christa, Loudet, Olivier, Weigel, Detlef, Ecker, Joseph R.

“…The handheld Oxford Nanopore MinION sequencer generates ultra-long reads with minimal cost and time requirements, which makes sequencing genomes at the bench…”
Get full text

Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex by Luo, Chongyuan, Keown, Christopher L., Kurihara, Laurie, Zhou, Jingtian, He, Yupeng, Li, Junhao, Castanon, Rosa, Lucero, Jacinta, Nery, Joseph R., Sandoval, Justin P., Bui, Brian, Sejnowski, Terrence J., Harkins, Timothy T., Mukamel, Eran A., Behrens, M. Margarita, Ecker, Joseph R.

“…The mammalian brain contains diverse neuronal types, yet we lack single-cell epigenomic assays that are able to identify and characterize them. DNA methylation…”
Get full text

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes by Florey, Oliver, Sandoval, Cynthia P, Haynes, Cole M, Kim, Sung Eun, Overholtzer, Michael

“…Autophagy normally involves the formation of double-membrane autophagosomes that mediate bulk cytoplasmic and organelle degradation. Here we report the…”
Get full text

Robust single-cell DNA methylome profiling with snmC-seq2 by Luo, Chongyuan, Rivkin, Angeline, Zhou, Jingtian, Sandoval, Justin P., Kurihara, Laurie, Lucero, Jacinta, Castanon, Rosa, Nery, Joseph R., Pinto-Duarte, António, Bui, Brian, Fitzpatrick, Conor, O’Connor, Carolyn, Ruga, Seth, Van Eden, Marc E., Davis, David A., Mash, Deborah C., Behrens, M. Margarita, Ecker, Joseph R.

“…Single-cell DNA methylome profiling has enabled the study of epigenomic heterogeneity in complex tissues and during cellular reprogramming. However, broader…”
Get full text

The complex architecture and epigenomic impact of plant T-DNA insertions by Jupe, Florian, Rivkin, Angeline C, Michael, Todd P, Zander, Mark, Motley, S Timothy, Sandoval, Justin P, Slotkin, R Keith, Chen, Huaming, Castanon, Rosa, Nery, Joseph R, Ecker, Joseph R

“…The bacterium Agrobacterium tumefaciens has been the workhorse in plant genome engineering. Customized replacement of native tumor-inducing (Ti) plasmid…”
Get full text

Kidneys at Higher Risk of Discard: Expanding the Role of Dual Kidney Transplantation by Tanriover, B., Mohan, S., Cohen, D. J., Radhakrishnan, J., Nickolas, T. L., Stone, P. W., Tsapepas, D. S., Crew, R. J., Dube, G. K., Sandoval, P. R., Samstein, B., Dogan, E., Gaston, R. S., Tanriover, J. N., Ratner, L. E., Hardy, M. A.

“…Half of the recovered expanded criteria donor (ECD) kidneys are discarded in the United States. A new kidney allocation system offers kidneys at higher risk of…”
Get full text

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures by Bouchi, Ryotaro, Foo, Kylie S., Hua, Haiqing, Tsuchiya, Kyoichiro, Ohmura, Yoshiaki, Sandoval, P. Rodrigo, Ratner, Lloyd E., Egli, Dieter, Leibel, Rudolph L., Accili, Domenico

“…Generation of surrogate sources of insulin-producing β-cells remains a goal of diabetes therapy. While most efforts have been directed at differentiating…”
Get full text

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia by Beigneux, Anne P, Miyashita, Kazuya, Ploug, Michael, Blom, Dirk J, Ai, Masumi, Linton, MacRae F, Khovidhunkit, Weerapan, Dufour, Robert, Garg, Abhimanyu, McMahon, Maureen A, Pullinger, Clive R, Sandoval, Norma P, Hu, Xuchen, Allan, Christopher M, Larsson, Mikael, Machida, Tetsuo, Murakami, Masami, Reue, Karen, Tontonoz, Peter, Goldberg, Ira J, Moulin, Philippe, Charrière, Sybil, Fong, Loren G, Nakajima, Katsuyuki, Young, Stephen G

“…Six patients with severe hypertriglyceridemia (chylomicronemia) were found to have autoantibodies against a capillary endothelial-cell protein (GPIHBP1) that…”
Get full text

Disparities in Access to Timely Waitlisting Among Pediatric Kidney Transplant Candidates by Maclay, Lindsey M, Yu, Miko, Amaral, Sandra, Adler, Joel T, Sandoval, P Rodrigo, Ratner, Lloyd E, Schold, Jesse D, Mohan, Sumit, Husain, Syed Ali

“…Kidney transplantation with minimal or no dialysis exposure provides optimal outcomes for children with end-stage kidney disease. We sought to understand…”
Get full text

High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS by He, Cuiwen, Hu, Xuchen, Jung, Rachel S., Weston, Thomas A., Sandoval, Norma P., Tontonoz, Peter, Kilburn, Matthew R., Fong, Loren G., Young, Stephen G., Jiang, Haibo

“…Cholesterol is a crucial lipid within the plasma membrane of mammalian cells. Recent biochemical studies showed that one pool of cholesterol in the plasma…”
Get full text

Lipoprotein lipase is active as a monomer by Beigneux, Anne P., Allan, Christopher M., Sandoval, Norma P., Cho, Geoffrey W., Heizer, Patrick J., Jung, Rachel S., Stanhope, Kimber L., Havel, Peter J., Birrane, Gabriel, Meiyappan, Muthuraman, Gill, John E., Murakami, Masami, Miyashita, Kazuya, Nakajima, Katsuyuki, Ploug, Michael, Fong, Loren G., Young, Stephen G.

“…Lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma lipoproteins, is assumed to be active only as a homodimer. In support of this…”
Get full text

Enlightening brain energy metabolism by Barros, L.F., Ruminot, I., Sandoval, P.Y., San Martín, A.

“…Brain tissue metabolism is distributed across several cell types and subcellular compartments, which activate at different times and with different temporal…”
Get full text

Frequency response analysis of the Bautista-Manero-Puig model with normal stress: analytical and numerical solution for large amplitudes by Hernandez, E., Bautista, F., García-Sandoval, J. P., Manero, O.

“…We derive explicit analytical expressions for the recurrence relations using the analytical matrix method for frequency response and the Bautista-Manero-Puig…”
Get full text

Modern laser in situ keratomileusis outcomes by Sandoval, Helga P., MD, MSCR, Donnenfeld, Eric D., MD, Kohnen, Thomas, MD, PhD, FEBO, Lindstrom, Richard L., MD, Potvin, Richard, OD, Tremblay, David M., MD, Solomon, Kerry D., MD

“…Laser in situ keratomileusis (LASIK) articles published between 2008 and 2015 that contain clinical outcomes data were reviewed and graded for quality,…”
Get full text

Host-plant adaptation drives the parallel evolution of reproductive isolation by Nosil, Patrik, Crespi, Bernard J, Sandoval, Cristina P

“…Parallel evolution of similar traits in independent populations that inhabit ecologically similar environments strongly implicates natural selection as the…”
Get full text

A simple unstructured kinetic model for anaerobic treatment of a class of agro‐industrial waste by Arroyo, Claudio B., Mendez‐Acosta, Hugo O., García‐Sandoval, Juan P., Leal‐Ascencio, Teresa, Hernandez‐Martinez, Eliseo

“…BACKGROUND Dynamic modeling of the anaerobic treatment of agro‐industrial waste can help determine optimal operating conditions to maximize the process…”
Get full text

Visualizing physiological parameters in cells and tissues using genetically encoded indicators for metabolites by San Martín, A., Arce-Molina, R., Aburto, C., Baeza-Lehnert, F., Barros, L.F., Contreras-Baeza, Y., Pinilla, A., Ruminot, I., Rauseo, D., Sandoval, P.Y.

“…The study of metabolism is undergoing a renaissance. Since the year 2002, over 50 genetically-encoded fluorescent indicators (GEFIs) have been introduced,…”
Get full text

Procurement Biopsies in the Evaluation of Deceased Donor Kidneys by Carpenter, Dustin, Husain, S Ali, Brennan, Corey, Batal, Ibrahim, Hall, Isaac E, Santoriello, Dominick, Rosen, Raphael, Crew, R John, Campenot, Eric, Dube, Geoffrey K, Radhakrishnan, Jai, Stokes, M Barry, Sandoval, P Rodrigo, D'Agati, Vivette, Cohen, David J, Ratner, Lloyd E, Markowitz, Glen, Mohan, Sumit

“…Biopsies taken at deceased donor kidney procurement continue to be cited as a leading reason for discard; however, the reproducibility and prognostic…”
Get full text

Association between Reperfusion Renal Allograft Biopsy Findings and Transplant Outcomes by Mohan, Sumit, Campenot, Eric, Chiles, Mariana C, Santoriello, Dominick, Bland, Eric, Crew, R John, Rosenstiel, Paul, Dube, Geoffrey, Batal, Ibrahim, Radhakrishnan, Jai, Sandoval, P Rodrigo, Guarrera, James, Stokes, M Barry, D'Agati, Vivette, Cohen, David J, Ratner, Lloyd E, Markowitz, Glen

“…Biopsy findings at the time of procurement of deceased donor kidneys remain the most common reason cited for kidney discard. To determine the value of renal…”
Get full text