Search Results - "P. Marks"

Discovery and development of SAHA as an anticancer agent by Marks, P A

“…The path to the discovery of suberoylanilide hydroxamic acid (SAHA, vorinostat) began over three decades ago with our studies designed to understand why…”
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Histone deacetylase inhibitors: molecular mechanisms of action by Xu, W S, Parmigiani, R B, Marks, P A

“…This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors (HDACi), a group of recently discovered 'targeted' anticancer agents…”
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A Personal Commentary on the Two Conferences on Health and Human Rights by MARKS, STEPHEN P.

“…Marks reflects on the two conferences on health and human rights that took place in 1994 and 1996. He acknowledges the significant impact these conferences had…”
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Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis by Jovin, Tudor G, Nogueira, Raul G, Lansberg, Maarten G, Demchuk, Andrew M, Martins, Sheila O, Mocco, J, Ribo, Marc, Jadhav, Ashutosh P, Ortega-Gutierrez, Santiago, Hill, Michael D, Lima, Fabricio O, Haussen, Diogo C, Brown, Scott, Goyal, Mayank, Siddiqui, Adnan H, Heit, Jeremy J, Menon, Bijoy K, Kemp, Stephanie, Budzik, Ron, Urra, Xabier, Marks, Michael P, Costalat, Vincent, Liebeskind, David S, Albers, Gregory W

“…Trials examining the benefit of thrombectomy in anterior circulation proximal large vessel occlusion stroke have enrolled patients considered to have…”
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Histone deacetylase inhibitors: Potential in cancer therapy by Marks, P.A., Xu, W.-S.

“…The role of histone deacetylases (HDAC) and the potential of these enzymes as therapeutic targets for cancer, neurodegenerative diseases and a number of other…”
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Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging by Albers, Gregory W, Marks, Michael P, Kemp, Stephanie, Christensen, Soren, Tsai, Jenny P, Ortega-Gutierrez, Santiago, McTaggart, Ryan A, Torbey, Michel T, Kim-Tenser, May, Leslie-Mazwi, Thabele, Sarraj, Amrou, Kasner, Scott E, Ansari, Sameer A, Yeatts, Sharon D, Hamilton, Scott, Mlynash, Michael, Heit, Jeremy J, Zaharchuk, Greg, Kim, Sun, Carrozzella, Janice, Palesch, Yuko Y, Demchuk, Andrew M, Bammer, Roland, Lavori, Philip W, Broderick, Joseph P, Lansberg, Maarten G

“…In this trial in patients with stroke who had a mismatch between sizes of early infarction and a hypoperfused brain region, endovascular thrombectomy at 6 to…”
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Hypoperfusion Intensity Ratio Predicts Infarct Progression and Functional Outcome in the DEFUSE 2 Cohort by Olivot, Jean Marc, Mlynash, Michael, Inoue, Manabu, Marks, Michael P, Wheeler, Hayley M, Kemp, Stephanie, Straka, Matus, Zaharchuk, Gregory, Bammer, Roland, Lansberg, Maarten G, Albers, Gregory W

“…BACKGROUND AND PURPOSE—We evaluate associations between the severity of magnetic resonance perfusion-weighted imaging abnormalities, as assessed by the…”
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Effect of Air Temperature and Velocity on Listeria monocytogenes Inactivation During Drying of Apple Slices by Randriamiarintsoa, Narindra, Ryser, Elliot T., Marks, Bradley P.

“…•Listeria survival was greater at 60 than 80 °C, regardless of air velocity.•Inactivation of Listeria was greater at higher air velocity.•Final moisture…”
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Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3 by Rao, Vaishnavi L, Mlynash, Michael, Christensen, Søren, Yennu, Amarnath, Kemp, Stephanie, Zaharchuk, Greg, Heit, Jeremy J, Marks, Michael P, Lansberg, Maarten G, Albers, Gregory W

“…We previously demonstrated that in the DEFUSE 3 trial, the union of the baseline core and the 24-h Tmax > 6 s perfusion lesion predicts the infarct volume at…”
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A multicenter randomized controlled trial of endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3) by Albers, Gregory W, Lansberg, Maarten G, Kemp, Stephanie, Tsai, Jenny P, Lavori, Phil, Christensen, Soren, Mlynash, Michael, Kim, Sun, Hamilton, Scott, Yeatts, Sharon D, Palesch, Yuko, Bammer, Roland, Broderick, Joe, Marks, Michael P

“…Rationale Early reperfusion in patients experiencing acute ischemic stroke is effective in patients with large vessel occlusion. No randomized data are…”
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Stress, sublethal injury, resuscitation, and virulence of bacterial foodborne pathogens by Wesche, Alissa M, Gurtler, Joshua B, Marks, Bradley P, Ryser, Elliot T

“…Environmental stress and food preservation methods (e.g., heating, chilling, acidity, and alkalinity) are known to induce adaptive responses within the…”
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Computed tomographic perfusion to Predict Response to Recanalization in ischemic stroke by Lansberg, Maarten G., Christensen, Soren, Kemp, Stephanie, Mlynash, Michael, Mishra, Nishant, Federau, Christian, Tsai, Jenny P., Kim, Sun, Nogueria, Raul G., Jovin, Tudor, Devlin, Thomas G., Akhtar, Naveed, Yavagal, Dileep R., Haussen, Diogo, Dehkharghani, Seena, Bammer, Roland, Straka, Matus, Zaharchuk, Greg, Marks, Michael P., Albers, Gregory W.

“…Objective To assess the utility of computed tomographic (CT) perfusion for selection of patients for endovascular therapy up to 18 hours after symptom onset…”
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Factors Affecting the Adhesion of Flour Particles to Stainless-steel Surfaces and Vacuum Dry-cleaning by Klug, Ian M., Marks, Bradley P., Bergholz, Teresa M., Jeong, Sanghyup

“…•Flour had significantly higher triboelectric propensity at lower RH levels (20%).•Charged flour of 60–80 mesh range had higher adhesion rates than uncharged…”
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Effect of Collateral Blood Flow on Patients Undergoing Endovascular Therapy for Acute Ischemic Stroke by Marks, Michael P, Lansberg, Maarten G, Mlynash, Michael, Olivot, Jean-Marc, Straka, Matus, Kemp, Stephanie, McTaggart, Ryan, Inoue, Manabu, Zaharchuk, Greg, Bammer, Roland, Albers, Gregory W

“…BACKGROUND AND PURPOSE—Our aim was to determine the relationships between angiographic collaterals and diffusion/perfusion findings, subsequent infarct growth,…”
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Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells by Marks, Paul A., Richon, Victoria M., Rifkind, Richard A.

“…Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth arrest, differentiation, and/or apoptotic cell death of transformed cells…”
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Seed Dispersal by White-Tailed Deer: Implications for Long-Distance Dispersal, Invasion, and Migration of Plants in Eastern North America by Myers, Jonathan A., Vellend, Mark, Gardescu, Sana, Marks, P. L.

“…For many plant species in eastern North America, short observed seed dispersal distances (ranging up to a few tens of meters) fail to explain rapid rates of…”
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Listeriosis Risk Model for Cancer Patients Who Consume Ready-to-Eat Salad by Gomez, Carly B., Mitchell, Jade, Ryser, Elliot T., Marks, Bradley P.

“…The foodborne pathogen Listeria monocytogenes generally infects immunocompromised individuals, such as cancer patients, more frequently and with higher…”
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HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation by Parmigiani, R.B, Xu, W.S, Venta-Perez, G, Erdjument-Bromage, H, Yaneva, M, Tempst, P, Marks, P.A

“…Eighteen histone deacetylases (HDACs) are present in humans, categorized into two groups: zinc-dependent enzymes (HDAC1-11) and NAD⁺-dependent enzymes…”
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Optimal Tmax Threshold for Predicting Penumbral Tissue in Acute Stroke by Olivot, Jean-Marc, Mlynash, Michael, Thijs, Vincent N, Kemp, Stephanie, Lansberg, Maarten G, Wechsler, Lawrence, Bammer, Roland, Marks, Michael P, Albers, Gregory W

“…BACKGROUND AND PURPOSE—We sought to assess whether the volume of the ischemic penumbra can be estimated more accurately by altering the threshold selected for…”
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Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study by Albers, Gregory W., Thijs, Vincent N., Wechsler, Lawrence, Kemp, Stephanie, Schlaug, Gottfried, Skalabrin, Elaine, Bammer, Roland, Kakuda, Wataru, Lansberg, Maarten G., Shuaib, Ashfaq, Coplin, William, Hamilton, Scott, Moseley, Michael, Marks, Michael P.

“…Objective To determine whether prespecified baseline magnetic resonance imaging (MRI) profiles can identify stroke patients who have a robust clinical response…”
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