Search Results - "P. Clifford"

Liquid phase condensation in cell physiology and disease by Shin, Yongdae, Brangwynne, Clifford P.

“…Phase transitions are ubiquitous in nonliving matter, and recent discoveries have shown that they also play a key role within living cells. Intracellular…”
Get full text

Polymer physics of intracellular phase transitions by Brangwynne, Clifford P., Tompa, Peter, Pappu, Rohit V.

“…Intracellular organelles are either membrane-bound vesicles or membrane-less compartments that are made up of proteins and RNA. These organelles play key…”
Get full text

Phase transitions and size scaling of membrane-less organelles by Brangwynne, Clifford P

“…The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic…”
Get full text

The liquid nucleome - phase transitions in the nucleus at a glance by Strom, Amy R, Brangwynne, Clifford P

“…Cells organize membrane-less internal compartments through a process called liquid-liquid phase separation (LLPS) to create chemically distinct compartments,…”
Get full text

Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition by Weber, Stephanie C., Brangwynne, Clifford P.

“…Just as organ size typically increases with body size, the size of intracellular structures changes as cells grow and divide. Indeed, many organelles, such as…”
Get full text

Nuclear bodies: the emerging biophysics of nucleoplasmic phases by Zhu, Lian, Brangwynne, Clifford P

“…The cell nucleus contains a large number of membrane-less bodies that play important roles in the spatiotemporal regulation of gene expression. Recent work…”
Get full text

Getting RNA and Protein in Phase by Weber, Stephanie C., Brangwynne, Clifford P.

“…Nonmembrane-bound organelles such as RNA granules behave like dynamic droplets, but the molecular details of their assembly are poorly understood. Several…”
Get full text

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells by Feric, Marina, Brangwynne, Clifford P.

“…Actin is abundant in the nuclei of oocytes but its role has been unclear. Feric and Brangwynne find that actin forms a network that prevents the sedimentation…”
Get full text

RNA Controls PolyQ Protein Phase Transitions by Zhang, Huaiying, Elbaum-Garfinkle, Shana, Langdon, Erin M., Taylor, Nicole, Occhipinti, Patricia, Bridges, Andrew A., Brangwynne, Clifford P., Gladfelter, Amy S.

“…Compartmentalization in cells is central to the spatial and temporal control of biochemistry. In addition to membrane-bound organelles, membrane-less…”
Get full text

Probing and engineering liquid-phase organelles by Bracha, Dan, Walls, Mackenzie T., Brangwynne, Clifford P.

“…Cells compartmentalize their intracellular environment to orchestrate countless simultaneous biochemical processes. Many intracellular tasks rely on…”
Get full text

Reactions and Products of Squalene and Ozone: A Review by Coffaro, Breann, Weisel, Clifford P.

“…This critical review describes the squalene-ozone (SqOz) reaction, or squalene ozonolysis. Ambient ozone penetrates indoors and drives indoor air chemistry…”
Get full text

Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets by Shin, Yongdae, Berry, Joel, Pannucci, Nicole, Haataja, Mikko P., Toettcher, Jared E., Brangwynne, Clifford P.

“…Phase transitions driven by intrinsically disordered protein regions (IDRs) have emerged as a ubiquitous mechanism for assembling liquid-like RNA/protein (RNP)…”
Get full text

Quantifying Dynamics in Phase-Separated Condensates Using Fluorescence Recovery after Photobleaching by Taylor, Nicole O., Wei, Ming-Tzo, Stone, Howard A., Brangwynne, Clifford P.

“…Cells contain numerous membraneless organelles that assemble by intracellular liquid-liquid phase separation. The viscous properties and associated…”
Get full text

Manganese Electrocatalysts with Bulky Bipyridine Ligands: Utilizing Lewis Acids To Promote Carbon Dioxide Reduction at Low Overpotentials by Sampson, Matthew D, Kubiak, Clifford P

“…Earth-abundant manganese bipyridine (bpy) complexes are well-established molecular electrocatalysts for proton-coupled carbon dioxide (CO2) reduction to carbon…”
Get full text

Facile Solvent-Free Synthesis of Thin Iron Porphyrin COFs on Carbon Cloth Electrodes for CO2 Reduction by Cheung, Po Ling, Lee, Sze Koon, Kubiak, Clifford P

“…We demonstrate the solvent-free synthesis of a covalent organic framework (COF) containing 5,10,15,20-tetra-(4-aminophenyl)­porphyrin Fe­(III) chloride…”
Get full text

RNA transcription modulates phase transition-driven nuclear body assembly by Berry, Joel, Weber, Stephanie C., Vaidya, Nilesh, Haataja, Mikko, Brangwynne, Clifford P.

“…Nuclear bodies are RNA and protein-rich, membraneless organelles that play important roles in gene regulation. The largest and most well-known nuclear body is…”
Get full text

Composition-dependent thermodynamics of intracellular phase separation by Riback, Joshua A., Zhu, Lian, Ferrolino, Mylene C., Tolbert, Michele, Mitrea, Diana M., Sanders, David W., Wei, Ming-Tzo, Kriwacki, Richard W., Brangwynne, Clifford P.

“…Intracellular bodies such as nucleoli, Cajal bodies and various signalling assemblies represent membraneless organelles, or condensates, that form via…”
Get full text

Homogeneous CO2 Reduction by Ni(cyclam) at a Glassy Carbon Electrode by Froehlich, Jesse D, Kubiak, Clifford P

“…The homogeneous CO2 reduction activity of several nickel cyclam complexes was examined by cyclic voltammetry and controlled potential electrolysis. CO…”
Get full text

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds by Bracha, Dan, Walls, Mackenzie T., Wei, Ming-Tzo, Zhu, Lian, Kurian, Martin, Avalos, José L., Toettcher, Jared E., Brangwynne, Clifford P.

“…Liquid-liquid phase separation plays a key role in the assembly of diverse intracellular structures. However, the biophysical principles by which phase…”
Get full text

disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics by Elbaum-Garfinkle, Shana, Kim, Younghoon, Szczepaniak, Krzysztof, Chen, Carlos Chih-Hsiung, Eckmann, Christian R., Myong, Sua, Brangwynne, Clifford P.

“…P granules and other RNA/protein bodies are membrane-less organelles that may assemble by intracellular phase separation, similar to the condensation of water…”
Get full text