Search Results - "P. Acker, Jason"

Trehalose-Based Polyethers for Cryopreservation and Three-Dimensional Cell Scaffolds by Diaz-Dussan, Diana, Peng, Yi-Yang, Sengupta, Jayeeta, Zabludowski, Rebecca, Adam, Madeleine K, Acker, Jason P, Ben, Robert N, Kumar, Piyush, Narain, Ravin

“…The capability to slow ice growth and recrystallization is compulsory in the cryopreservation of cells and tissues to avoid injuries associated with the…”
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Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality by Almizraq, Ruqayyah, Tchir, Jayme D.R., Holovati, Jelena L., Acker, Jason P.

“…Background During storage detrimental biochemical and biomechanical changes occur within a red blood cell (RBC). RBC microparticles (RMPs) produced during…”
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The timing of gamma irradiation and its effect on cell‐free and microvesicle‐bound hemoglobin. The BEST collaborative study by William, Nishaka, Bicahlo, Beatriz, Hansen, Adele, Korte, Dirk, Acker, Jason P.

“…Background Gamma irradiation of red cell concentrates (RCCs) is regularly used to prevent transfusion‐associated graft‐versus‐host disease (TA‐GvHD) in at‐risk…”
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Transfusion of female blood in a rat model is associated with red blood cells entrapment in organs by Alshalani, Abdulrahman, de Wissel, Marit B, Tuip-de Boer, Anita M, Roelofs, Joris J. T. H, van Bruggen, Robin, Acker, Jason P, Juffermans, Nicole P

“…Transfusion of red blood cells (RBCs) has been associated with adverse outcomes. Mechanisms may be related to donor sex and biological age of RBC. This study…”
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The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation by Lewis, Jedediah K., Bischof, John C., Braslavsky, Ido, Brockbank, Kelvin G.M., Fahy, Gregory M., Fuller, Barry J., Rabin, Yoed, Tocchio, Alessandro, Woods, Erik J., Wowk, Brian G., Acker, Jason P., Giwa, Sebastian

“…The first Organ Banking Summit was convened from Feb. 27 - March 1, 2015 in Palo Alto, CA, with events at Stanford University, NASA Research Park, and Lawrence…”
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Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing by Briard, Jennie G., Poisson, Jessica S., Turner, Tracey R., Capicciotti, Chantelle J., Acker, Jason P., Ben, Robert N.

“…During cryopreservation, ice recrystallization is a major cause of cellular damage. Conventional cryoprotectants such as dimethyl sulfoxide (DMSO) and glycerol…”
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Impact of technical and assay variation on reporting of hemolysis in stored red blood cell products by Almizraq, Ruqayyah J., Yi, Qi Long, Acker, Jason P.

“…Hemolysis of RBCs is an important measure of product quality and is influenced by donor factors, blood component manufacturing and storage. Percent hemolysis…”
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Ice recrystallization inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis by Mommaerts, Kathleen, Okawa, Satoshi, Schmitt, Margaux, Kofanova, Olga, Turner, Tracey R., Ben, Robert N., Del Sol, Antonio, Mathieson, William, Schwamborn, Jens C., Acker, Jason P., Betsou, Fay

“…•Cryopreservation protocols development for induced pluripotent stem cells (iPSCs).•We assessed ice recrystallization inhibitors (IRIs) for iPSCs…”
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Comparing two extracellular additives to facilitate extended storage of red blood cells in a supercooled state by William, Nishaka, Isiksacan, Ziya, Mykhailova, Olga, Olafson, Carly, Yarmush, Martin L, Usta, O Berk, Acker, Jason P

“…Adenosine triphosphate (ATP) levels guide many aspects of the red blood cell (RBC) hypothermic storage lesions. As a result, efforts to improve the quality of…”
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Evaluating the quality of red blood cell concentrates irradiated before or after cryopreservation by Turner, Tracey R., Lautner, Larissa, Hill, Angela, Howell, Anita, Skeate, Robert, Acker, Jason P.

“…BACKGROUND Cryopreserved red blood cell concentrates (RCCs) are often required for patients with rare blood groups. Although transfusions from blood relatives…”
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The impact of biological age of red blood cell on in vitro endothelial activation markers by Alshalani, Abdulrahman, Beuger, Boukje M, Tuip-de Boer, Anita M, van Bruggen, Robin, Acker, Jason P, Juffermans, Nicole P

“…Blood donor characteristics influence red blood cell transfusion outcomes. As donor sex affects the distribution of young to old RBCs in the circulation, we…”
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Timing of gamma irradiation and blood donor sex influences in vitro characteristics of red blood cells by de Korte, Dirk, Thibault, Louis, Handke, Wiebke, Harm, Sarah K., Morrison, Alex, Fitzpatrick, Aine, Marks, Denese C., Yi, Qi‐Long, Acker, Jason P.

“…BACKGROUND There are few studies investigating the effect of irradiation on red blood cells (RBCs) during storage. This study analyzed changes in in vitro…”
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Quality of red blood cells washed using the ACP 215 cell processor: assessment of optimal pre- and postwash storage times and conditions by Hansen, Adele, Yi, Qi-Long, Acker, Jason P.

“…Background Washing of red blood cell concentrates (RCCs) is required for potassium‐sensitive transfusion recipients, including neonates in need of large‐volume…”
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The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients by Alshalani, Abdulrahman, van Manen, Lisa, Boshuizen, Margit, van Bruggen, Robin, Acker, Jason P., Juffermans, Nicole P.

“…Background: Observational studies suggest that sex-mismatched transfusion is associated with increased mortality. Mechanisms driving mortality are not known…”
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Pragmatic, double-blind, randomised trial evaluating the impact of red blood cell donor sex on recipient mortality in an academic hospital population: the innovative Trial Assessing Donor Sex (iTADS) protocol by Fergusson, Dean A, Chassé, Michael, Tinmouth, Alan, Acker, Jason P, English, Shane, Forster, Alan J, Hawken, Steven, Shehata, Nadine, Thavorn, Kednapa, Wilson, Kumanan, Tuttle, Angie, Perelman, Iris, Cober, Nancy, Maddison, Heather, Tokessy, Melanie

“…IntroductionWith over 1 million units of blood transfused each year in Canada, their use has a significant clinical and economic impact on our health system…”
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Red‐blood‐cell manufacturing methods and storage solutions differentially induce pulmonary cell activation by Wirtz, Mathijs R., Almizraq, Ruqayyah J., Weber, Nina C., Norris, Philip J., Pandey, Suchitra, Spinella, Philip C., Muszynski, Jennifer A., P. Acker, Jason, Juffermans, Nicole P.

“…Background and Objectives Red‐blood‐cell (RBC) transfusion is associated with lung injury, which is further exacerbated by mechanical ventilation…”
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Extended supercooled storage of red blood cells by Isiksacan, Ziya, William, Nishaka, Senturk, Rahime, Boudreau, Luke, Wooning, Celine, Castellanos, Emily, Isiksacan, Salih, Yarmush, Martin L., Acker, Jason P., Usta, O. Berk

“…Red blood cell (RBC) transfusions facilitate many life-saving acute and chronic interventions. Transfusions are enabled through the gold-standard hypothermic…”
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Editorial: Advancing the cryopreservation of cells, tissues and organs using model biological systems by Acker, Jason P.

“…This Editorial introduces and contextualizes the papers of the Virtual Special Issue: Advancing the Cryopreservation of Cells, Tissues and Organs Using Model…”
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Synergistic effects of liposomes, trehalose, and hydroxyethyl starch for cryopreservation of human erythrocytes by Stoll, Christoph, Holovati, Jelena L., Acker, Jason P., Wolkers, Willem F.

“…Red blood cells (RBCs) can be cryopreserved using glycerol as a cryoprotective agent, but one of the main disadvantages is the time‐consuming deglycerolization…”
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Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells by Bissinger, Rosi, Petkova-Kirova, Polina, Mykhailova, Olga, Oldenborg, Per-Arne, Novikova, Elena, Donkor, David A, Dietz, Thomas, Bhuyan, Abdulla Al Mamun, Sheffield, William P, Grau, Marijke, Artunc, Ferruh, Kaestner, Lars, Acker, Jason P, Qadri, Syed M

“…Thrombospondin-1 (TSP-1), a Ca -binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical…”
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